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The map label for this gene is ffh [H]

Identifier: 148827249

GI number: 148827249

Start: 568513

End: 569901

Strand: Reverse

Name: ffh [H]

Synonym: CGSHiGG_03095

Alternate gene names: 148827249

Gene position: 569901-568513 (Counterclockwise)

Preceding gene: 148827251

Following gene: 148827245

Centisome position: 30.2

GC content: 43.34

Gene sequence:

>1389_bases
ATGTTTGAGAATTTATCGGATCGCCTTTCCAAAACTTTACGTAATATCACAGGAAAAGGCCGTTTAACGGAAGATAATAT
TAAAGAAACCTTGCGCGAAGTACGTATGGCATTACTTGAAGCCGATGTTGCCTTGCCTGTGGTGCGTGAATTTATCGCAA
AAGTAAAAGAAAGCGCGCTTGGGGAAGAAGTCAATAAAAGTTTAACGCCAGGGCAAGAATTCTTAAAAATCGTTCAGCAT
GAGCTTGAAAAAGCCATGGGCGAAGCGAATGAGAGTTTAAATCTCGCAACCCAACCACCAGCAGTTATCTTAATGGCGGG
TTTACAAGGGGCGGGTAAAACCACCAGTGTGGGTAAATTGGCAAAATTCTTGCGTGAACGCCATAAAAAGAAAGTGTTAG
TGGTGTCTGCTGACGTATATCGCCCTGCTGCGATTAAGCAACTTGAAACCTTGGCTCAATCCGTTGGCGTGGATTTTTTT
CCATCGGATGTTAAACAAAACCCCGTTGATATTGCTAAATCGGCGCTTGCTGATGCAAAACTGAAATTCTACGATGTGTT
GATTGTGGATACGGCAGGTCGCCTACACGTTGATACAGAAATGATGGACGAAATCAAGCAAGTCCATGCTGCATTAAATC
CAATCGAAACTCTTTTCACTGTTGATGCGATGACTGGTCAAGATGCGGCAAATACAGCAAAAGCCTTTAATGAAGCATTG
CCTCTTACAGGGGTTGTTTTGACGAAAGTGGACGGTGATGCGCGCGGTGGTGCGGCGTTATCGATTCGTCAAATCACAGG
TAAACCAATTAAATTCTTGGGTGTGGGTGAGAAAACGGAGGCACTTGAGCCGTTCCATCCTGATCGTGTTGCTTCTCGTA
TTTTGGGCATGGGCGATGTGCTTTCCCTTATCGAAGATCTTGAACGTTCAGTTGATCGTGAAAAAGCGGAAAAAATGGCG
CAGAAATTCAAGAAAGGCGATGGTTTTACTTTAGATGATTTCCGCGAACAGCTGATCGAAATGAAAAAAATGGGCGGCAT
GATGTCTATGCTTGAGAAATTACCAGGTGCAAAAAATTTGCCTGAGCACGTTAAAAATCAAGTGGATGACAAAATGTTTG
TCAAAATGGAAGCGATCATTAACTCCATGACCCTAAAAGAACGTGCAAACCCAGATATTATCAAAGGATCTCGCCGTCGT
CGTATTGCATTAGGTTCTGGCACTCAAGTGCAAGATGTCAATAAATTACTTAAACAATTCGATGAAATGCAACGTATGAT
GAAGAAAATGCGTAAAGGCGGCATGGCTAAAATGATGCGTGGAATGCAAGGCTTAATGGGCGGAGGCTTAGGCGGTCTTG
GCGGTTTAGGCGGAATGTTTAAACGATAA

Upstream 100 bases:

>100_bases
AATCGCCTACTCAAAAAGTCATTTTCATTTGAAATGATGAAAAACGCCTAAATTTCGGTATAATCAGCACAATTTTTTAA
GAAAAACAGGATTGTTAGCC

Downstream 100 bases:

>100_bases
TTTCAGAAGATAAAAGTGCGGTTAAAAAAGAAATATTTTTACCGCACTTTTGTGTTTTATGAATTATAGCTAATTTATAA
ATTATTCTAATTAACGACGT

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQH
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKSALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDGFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLPEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR

Sequences:

>Translated_462_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQH
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKSALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDGFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLPEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR
>Mature_462_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQH
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKSALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDGFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLPEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=448, Percent_Identity=32.3660714285714, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI226371618, Length=376, Percent_Identity=33.2446808510638, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=35.1515151515151, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI23308697, Length=222, Percent_Identity=29.7297297297297, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI295424842, Length=222, Percent_Identity=29.7297297297297, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=80.5309734513274, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=36.2204724409449, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=29.8206278026906, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193206261, Length=216, Percent_Identity=32.4074074074074, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=438, Percent_Identity=32.1917808219178, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=25.9493670886076, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17647949, Length=433, Percent_Identity=29.0993071593533, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24641198, Length=268, Percent_Identity=28.3582089552239, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50763; Mature: 50763

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVNKSLTPGQEFLKIVQHELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFFPSDVKQNPVDIAKSALADAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEHHCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDGFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
PEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHCCHHCCC
>Mature Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVNKSLTPGQEFLKIVQHELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFFPSDVKQNPVDIAKSALADAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEHHCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDGFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
PEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]