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The map label for this gene is mutL [H]

Identifier: 148827220

GI number: 148827220

Start: 524374

End: 526263

Strand: Direct

Name: mutL [H]

Synonym: CGSHiGG_02850

Alternate gene names: 148827220

Gene position: 524374-526263 (Clockwise)

Preceding gene: 148827219

Following gene: 148827221

Centisome position: 27.79

GC content: 39.37

Gene sequence:

>1890_bases
ATGCCTATTAAAATTCTTTCCCCACAACTTGCTAACCAAATTGCTGCTGGAGAAGTGGTAGAACGCCCTGCATCAGTGGT
AAAAGAATTAGTGGAAAATAGCCTTGATGCAGGTGCAAATAAAATCCAAATTGATATCGAAAATGGTGGGGCAAATTTAA
TCCGCATTCGTGACAATGGCTGTGGTATTCCAAAAGAAGAATTAAGCCTCGCTTTGGCACGACATGCCACGAGTAAAATA
GCCGATCTTGATGATCTCGAAGCGATTTTAAGTTTAGGTTTTCGTGGCGAGGCATTAGCTAGTATCAGTTCCGTATCACG
CCTAACCCTTACTTCTCGTACCGAAGAACAAACTGAAGCGTGGCAAGTTTATGCGCAAGGTCGTGATATGGAAACCACAA
TCAAACCCGCATCACATCCTGTCGGCACAACAGTTGAAGTCGCCAATCTTTTTTTCAATACGCCAGCCCGCCGAAAATTT
TTGCGCACAGATAAAACAGAATTTGCTCATATTGATGAAGTCATTCGCCGCATTGCTTTAACAAAATTCAATACGGCATT
TACATTAACGCATAATGGGAAAATTATCCGTCAATATCGTCCTGCTGAAGAGCTCAATCAGCAACTAAAACGTGTCGCCG
CTATTTGTGGGGATGATTTTGTCAAAAATGCCTTACGAATTGATTGGAAACACGATGATTTACACTTATCTGGCTGGGTA
GCTAAACCAAATTTTAGCCGAACTCAAAATGATTTAAGTTATTGCTATATTAATGGTCGAATGGTGAGAGATAAAGTGAT
CAGCCATGCTATTCGACAAGCCTATGCTCAATATTTACCAACCGATGCTTATCCTGCGTTTGTGTTGTTTATTGATTTAA
ACCCACACGATGTAGATGTCAATGTTCATCCAACCAAACATGAAGTACGCTTTCATCAACAACGTCTGATTCATGATTTT
ATTTACGAAGGCATAAGTTATGCACTAAACAATCAAGAACAGCTTAATTGGCATACAGACCAAAGTGCGGTAGAAAATCA
CGAAGAAAATACGGTGCGTGAGCCCCAACCGAATTACAGCATTCGTCCTAATCGTGCAGCTGCGGGGCAAAATAGCTTTG
CGCCACAATATCATGAAAAACCACAGCAAAATCAACCGCACTTTTCTAACACACCAGTGTTTCCAAATCATGTAAGTACT
GGTTATCGAGATTACCGTTCTGATGCACCGAGTAAAATTGAGCAACGTTTATATGCTGAATTGTTACGCACGTTACCGCC
TACAGCGCAAAAGGATATATCGGATACAGCACAACAAAATATTTCAGATACAGCTAAAATCATCTCAACTGAAATAATTG
AGTGTTCATCACATCTACGAGCCCTTTCACTTATTGAAAATCGTGCGTTGTTATTACAACAGAACCAAGATTTCTTTTTG
CTTTCATTGGAAAAATTACAACGCTTGCAATGGCAACTAGCGTTAAAACAAATACAGATTGAACAACAACCATTGTTGAT
TCCAATCGTATTTCGTTTAACGGAGGCACAATTTCAAGCATGGCAACAATATTCAGATAACTTCAAAAAAATTGGCTTTG
AATTTATCGAAAATCAAGCACAATTACGCTTAACCTTAAATAAAGTGCCAAGTGCATTACGCACACAAAATCTACAAAAA
TGCGTGATGGCAATGCTGACTAGAGATGAAAATTCATCATCATTTTTAACCGCACTTTGCGCACAATTAGAATGCAAAAC
CTTTAACACTTTAGCGGATGCACTCAATTTATTGAGCGAGACGGAACGTTTACTCACGCAAACAAACCGCACGGCATTCA
CCCAATTACTCAAACCTGTTAATTGGCAGCCTTTATTAGACGAAATTTAA

Upstream 100 bases:

>100_bases
GGAATATAACATTCCAGTAAATATACTATTGAGCCTAAATCCACATTTAAAAAATGGCAAAGTTATTACAGGACAAAAAA
TAAAATTAAGAGAAAAATAA

Downstream 100 bases:

>100_bases
ATTCTTCATGAAACCAACCGCAATTTTTTTAATGGGCCCAACAGCCTCAGGTAAAACAGATTTAGCCATTCAACTACGAA
GCCAACTTCCAGTCGAAGTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MPIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCGIPKEELSLALARHATSKI
ADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKF
LRTDKTEFAHIDEVIRRIALTKFNTAFTLTHNGKIIRQYRPAEELNQQLKRVAAICGDDFVKNALRIDWKHDDLHLSGWV
AKPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDVNVHPTKHEVRFHQQRLIHDF
IYEGISYALNNQEQLNWHTDQSAVENHEENTVREPQPNYSIRPNRAAAGQNSFAPQYHEKPQQNQPHFSNTPVFPNHVST
GYRDYRSDAPSKIEQRLYAELLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
LSLEKLQRLQWQLALKQIQIEQQPLLIPIVFRLTEAQFQAWQQYSDNFKKIGFEFIENQAQLRLTLNKVPSALRTQNLQK
CVMAMLTRDENSSSFLTALCAQLECKTFNTLADALNLLSETERLLTQTNRTAFTQLLKPVNWQPLLDEI

Sequences:

>Translated_629_residues
MPIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCGIPKEELSLALARHATSKI
ADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKF
LRTDKTEFAHIDEVIRRIALTKFNTAFTLTHNGKIIRQYRPAEELNQQLKRVAAICGDDFVKNALRIDWKHDDLHLSGWV
AKPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDVNVHPTKHEVRFHQQRLIHDF
IYEGISYALNNQEQLNWHTDQSAVENHEENTVREPQPNYSIRPNRAAAGQNSFAPQYHEKPQQNQPHFSNTPVFPNHVST
GYRDYRSDAPSKIEQRLYAELLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
LSLEKLQRLQWQLALKQIQIEQQPLLIPIVFRLTEAQFQAWQQYSDNFKKIGFEFIENQAQLRLTLNKVPSALRTQNLQK
CVMAMLTRDENSSSFLTALCAQLECKTFNTLADALNLLSETERLLTQTNRTAFTQLLKPVNWQPLLDEI
>Mature_628_residues
PIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCGIPKEELSLALARHATSKIA
DLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFL
RTDKTEFAHIDEVIRRIALTKFNTAFTLTHNGKIIRQYRPAEELNQQLKRVAAICGDDFVKNALRIDWKHDDLHLSGWVA
KPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDVNVHPTKHEVRFHQQRLIHDFI
YEGISYALNNQEQLNWHTDQSAVENHEENTVREPQPNYSIRPNRAAAGQNSFAPQYHEKPQQNQPHFSNTPVFPNHVSTG
YRDYRSDAPSKIEQRLYAELLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFLL
SLEKLQRLQWQLALKQIQIEQQPLLIPIVFRLTEAQFQAWQQYSDNFKKIGFEFIENQAQLRLTLNKVPSALRTQNLQKC
VMAMLTRDENSSSFLTALCAQLECKTFNTLADALNLLSETERLLTQTNRTAFTQLLKPVNWQPLLDEI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=319, Percent_Identity=35.7366771159875, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI4505911, Length=309, Percent_Identity=32.0388349514563, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI189458898, Length=309, Percent_Identity=32.0388349514563, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI189458896, Length=305, Percent_Identity=31.1475409836066, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4505913, Length=340, Percent_Identity=28.2352941176471, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=28.1976744186047, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI263191589, Length=225, Percent_Identity=30.6666666666667, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=25.5972696245734, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI91992160, Length=362, Percent_Identity=24.585635359116, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI91992162, Length=362, Percent_Identity=24.585635359116, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI263191733, Length=83, Percent_Identity=37.3493975903614, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI263191713, Length=83, Percent_Identity=37.3493975903614, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790612, Length=648, Percent_Identity=48.4567901234568, Blast_Score=565, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=33.4355828220859, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=27.0348837209302, Blast_Score=124, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=352, Percent_Identity=36.0795454545455, Blast_Score=200, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=357, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323063, Length=356, Percent_Identity=27.8089887640449, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325093, Length=441, Percent_Identity=24.0362811791383, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=35.8662613981763, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17136970, Length=363, Percent_Identity=28.099173553719, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71694; Mature: 71563

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNG
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
CGIPKEELSLALARHATSKIADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
WQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFAHIDEVIRRIAL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
TKFNTAFTLTHNGKIIRQYRPAEELNQQLKRVAAICGDDFVKNALRIDWKHDDLHLSGWV
HHCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCEEEEEEE
AKPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEE
NVHPTKHEVRFHQQRLIHDFIYEGISYALNNQEQLNWHTDQSAVENHEENTVREPQPNYS
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHCCCCCCCCCCCCCCC
IRPNRAAAGQNSFAPQYHEKPQQNQPHFSNTPVFPNHVSTGYRDYRSDAPSKIEQRLYAE
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
LLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCEEE
LSLEKLQRLQWQLALKQIQIEQQPLLIPIVFRLTEAQFQAWQQYSDNFKKIGFEFIENQA
EEHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QLRLTLNKVPSALRTQNLQKCVMAMLTRDENSSSFLTALCAQLECKTFNTLADALNLLSE
HEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TERLLTQTNRTAFTQLLKPVNWQPLLDEI
HHHHHHHCCHHHHHHHHCCCCCCCHHHCC
>Mature Secondary Structure 
PIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNG
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
CGIPKEELSLALARHATSKIADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
WQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFAHIDEVIRRIAL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
TKFNTAFTLTHNGKIIRQYRPAEELNQQLKRVAAICGDDFVKNALRIDWKHDDLHLSGWV
HHCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCEEEEEEE
AKPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEE
NVHPTKHEVRFHQQRLIHDFIYEGISYALNNQEQLNWHTDQSAVENHEENTVREPQPNYS
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHCCCCCCCCCCCCCCC
IRPNRAAAGQNSFAPQYHEKPQQNQPHFSNTPVFPNHVSTGYRDYRSDAPSKIEQRLYAE
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
LLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCEEE
LSLEKLQRLQWQLALKQIQIEQQPLLIPIVFRLTEAQFQAWQQYSDNFKKIGFEFIENQA
EEHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QLRLTLNKVPSALRTQNLQKCVMAMLTRDENSSSFLTALCAQLECKTFNTLADALNLLSE
HEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TERLLTQTNRTAFTQLLKPVNWQPLLDEI
HHHHHHHCCHHHHHHHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA