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The map label for this gene is kduD [C]

Identifier: 148827207

GI number: 148827207

Start: 507277

End: 508122

Strand: Reverse

Name: kduD [C]

Synonym: CGSHiGG_02760

Alternate gene names: 148827207

Gene position: 508122-507277 (Counterclockwise)

Preceding gene: 148827211

Following gene: 148827206

Centisome position: 26.92

GC content: 35.7

Gene sequence:

>846_bases
ATGTCAATTGCTAGAAAACATGATCTTAAAAATAAACTCATCGTTATTACTGGTGCAGGTGGAGTTTTATGTGCTTTTTT
AGCTAAGCAGTTGGTTCATACACAAGCTAACATCGCTTTATTAGATATTAACTTTGATGTGGCTAATGCTGTTGCTGATG
AAATTAACCAACAAGGCGGGAAAGCAAAAGCATATAAAACGGATGTATTGGATATTGATAGTCTAAAAGTAGTTCGGGAA
CAAATTATGCTGGATTTTGGTACTTGCGACATTTTAATTAATGGTGCGGGAGGTAATAATCCGAAAGCGACTACAGATAA
CGAATATCATCAACTTAATCTTAACGAAAATACCAAAACATTTTTTAATTTAGATAAATCAAGCATCGAGTTTGTGTTTA
ATTTGAACTACTTAGGAACACTTTTACCTACTCAAGTTTTTGCTCAAGATATGATTGGTAAACAAGGTGCAAACATTCTA
AATGTGTCTAGTATGAATGCCTTTACTCCATTGACAAAGATTCCTGCGTATTCTGGTGCGAAAGCCGCTATTAGTAACTT
TACCCAATGGCTGGCAGTATATTTTTCAAAAGTGGGCATTCGTTGCAATGCTATTGCTCCAGGTTTTTTAGTGAGCAACC
AAAATCAAGCATTACTTTTTGATGAACAAGGAAAACCAACACCGCGAGCAAATAAAATTTTAACCAATACTCCAATGGGA
CGTTTTGGTGAACCAGATGAACTTGTTGGTGGTGTGCTGTTTTTAATTGATGAAGCTTACGCAAGCTTTGTAAATGGAGT
GGTATTGCCAATTGATGGTGGTTTTTCTGCTTATAGTGGTGTTTAG

Upstream 100 bases:

>100_bases
GTGATGTATGTCACAAAATTGAAATAAATTGGTTTACCAATTTATTTTGATTGTGTACCATTTGATCAGTAGTTAATCAT
TTATGGAAGAGGGAATTATT

Downstream 100 bases:

>100_bases
TGACAGTGAATTAGGTGAAAAAATGCAAAATTTCAGTAAGCAAAAAGAGGTTATTGTTTGCGTAGATTCTGATGGATGTG
CAATGGATACAATGAATCTT

Product: D-mannonate oxidoreductase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSIARKHDLKNKLIVITGAGGVLCAFLAKQLVHTQANIALLDINFDVANAVADEINQQGGKAKAYKTDVLDIDSLKVVRE
QIMLDFGTCDILINGAGGNNPKATTDNEYHQLNLNENTKTFFNLDKSSIEFVFNLNYLGTLLPTQVFAQDMIGKQGANIL
NVSSMNAFTPLTKIPAYSGAKAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNQALLFDEQGKPTPRANKILTNTPMG
RFGEPDELVGGVLFLIDEAYASFVNGVVLPIDGGFSAYSGV

Sequences:

>Translated_281_residues
MSIARKHDLKNKLIVITGAGGVLCAFLAKQLVHTQANIALLDINFDVANAVADEINQQGGKAKAYKTDVLDIDSLKVVRE
QIMLDFGTCDILINGAGGNNPKATTDNEYHQLNLNENTKTFFNLDKSSIEFVFNLNYLGTLLPTQVFAQDMIGKQGANIL
NVSSMNAFTPLTKIPAYSGAKAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNQALLFDEQGKPTPRANKILTNTPMG
RFGEPDELVGGVLFLIDEAYASFVNGVVLPIDGGFSAYSGV
>Mature_280_residues
SIARKHDLKNKLIVITGAGGVLCAFLAKQLVHTQANIALLDINFDVANAVADEINQQGGKAKAYKTDVLDIDSLKVVREQ
IMLDFGTCDILINGAGGNNPKATTDNEYHQLNLNENTKTFFNLDKSSIEFVFNLNYLGTLLPTQVFAQDMIGKQGANILN
VSSMNAFTPLTKIPAYSGAKAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNQALLFDEQGKPTPRANKILTNTPMGR
FGEPDELVGGVLFLIDEAYASFVNGVVLPIDGGFSAYSGV

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=26.3374485596708, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI15277342, Length=285, Percent_Identity=25.6140350877193, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI66933014, Length=234, Percent_Identity=27.3504273504274, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7705925, Length=230, Percent_Identity=26.5217391304348, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=243, Percent_Identity=26.7489711934156, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4503301, Length=241, Percent_Identity=27.3858921161826, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI31542939, Length=203, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789208, Length=270, Percent_Identity=29.6296296296296, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787905, Length=267, Percent_Identity=30.3370786516854, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790717, Length=267, Percent_Identity=27.7153558052434, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788459, Length=229, Percent_Identity=27.5109170305677, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787335, Length=268, Percent_Identity=25.7462686567164, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI87082100, Length=270, Percent_Identity=27.037037037037, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082160, Length=268, Percent_Identity=24.6268656716418, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367175, Length=236, Percent_Identity=26.271186440678, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=154, Percent_Identity=33.7662337662338, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=275, Percent_Identity=27.6363636363636, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=251, Percent_Identity=28.2868525896414, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=196, Percent_Identity=31.1224489795918, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=271, Percent_Identity=26.9372693726937, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=278, Percent_Identity=26.2589928057554, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=201, Percent_Identity=27.363184079602, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=269, Percent_Identity=24.907063197026, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=281, Percent_Identity=24.5551601423488, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=197, Percent_Identity=28.4263959390863, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=207, Percent_Identity=28.5024154589372, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=229, Percent_Identity=24.8908296943231, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=231, Percent_Identity=25.974025974026, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=282, Percent_Identity=25.177304964539, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=203, Percent_Identity=28.0788177339901, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=212, Percent_Identity=26.8867924528302, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=275, Percent_Identity=24.3636363636364, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI23397609, Length=270, Percent_Identity=31.1111111111111, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357041, Length=271, Percent_Identity=25.4612546125461, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571526, Length=272, Percent_Identity=26.4705882352941, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639444, Length=270, Percent_Identity=25.1851851851852, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644337, Length=268, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644339, Length=274, Percent_Identity=27.7372262773723, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24643142, Length=271, Percent_Identity=28.7822878228782, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=269, Percent_Identity=23.0483271375465, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24665243, Length=230, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 30315; Mature: 30184

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIARKHDLKNKLIVITGAGGVLCAFLAKQLVHTQANIALLDINFDVANAVADEINQQGG
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCC
KAKAYKTDVLDIDSLKVVREQIMLDFGTCDILINGAGGNNPKATTDNEYHQLNLNENTKT
CCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCE
FFNLDKSSIEFVFNLNYLGTLLPTQVFAQDMIGKQGANILNVSSMNAFTPLTKIPAYSGA
EEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCCCCH
KAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNQALLFDEQGKPTPRANKILTNTPMG
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEECCCCCEEEECCCCCCCCCCCEEEECCCCC
RFGEPDELVGGVLFLIDEAYASFVNGVVLPIDGGFSAYSGV
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHCCCC
>Mature Secondary Structure 
SIARKHDLKNKLIVITGAGGVLCAFLAKQLVHTQANIALLDINFDVANAVADEINQQGG
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCC
KAKAYKTDVLDIDSLKVVREQIMLDFGTCDILINGAGGNNPKATTDNEYHQLNLNENTKT
CCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCE
FFNLDKSSIEFVFNLNYLGTLLPTQVFAQDMIGKQGANILNVSSMNAFTPLTKIPAYSGA
EEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCCCCH
KAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNQALLFDEQGKPTPRANKILTNTPMG
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEECCCCCEEEECCCCCCCCCCCEEEECCCCC
RFGEPDELVGGVLFLIDEAYASFVNGVVLPIDGGFSAYSGV
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]