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The map label for this gene is rnb [H]

Identifier: 148827149

GI number: 148827149

Start: 431909

End: 433888

Strand: Reverse

Name: rnb [H]

Synonym: CGSHiGG_02405

Alternate gene names: 148827149

Gene position: 433888-431909 (Counterclockwise)

Preceding gene: 148827150

Following gene: 148827148

Centisome position: 22.99

GC content: 42.93

Gene sequence:

>1980_bases
ATGTTTCAAGATAATCCTCTACTCGCACAACTTAAACAACAAATCCACGACAGCAAAGAACAGGTTGAGGGCGTGGTAAA
AAGCACAGATAAAGCCTACGGTTTTTTAGAGTGCGATAAAAAAACCTATTTCATCGCACCGCCATCAATGAAAAAAGTGA
TGCACGGCGACAAAATCAAAGCCACTATTGAAAAACAAGGCGACAAAGAACAAGCCGAGCCGGAATCCTTAATTGAGCCA
ATGCTCACACGTTTTATCGCAAAAGTGCGGTTCAATAAAGACAAGAAATTACAAGTGCTGGTGGATCACCCAAACATTAA
TCAACCCATTGGCGCGCAACAGGCGAAATCGGTAAAAGAAGAATTGCAAGAGGGCGACTGGGTCGTCGCAAATTTAAAAA
CCCATCCATTACGTGACGATCGCTTTTTCTATGCCACTATTAATCAGTTTATTTGCCGTGCAGAGGACGAACTCGCCCCT
TGGTGGGTCACATTGGCACGCCACGAACAATCGCGCTATCCCGTGCGAGGCGCAGAACCTTATGAAATGTTAGATCAAAA
AACACGCGAAAATCTGACCGCACTTCATTTTGTAACCATTGATTCCGAAAGCACAATGGATATGGACGATGCCTTATATA
TCGAACCCATAGCACAAAACAGCACACAAACAGGCTGGAAATTAGTGGTCGCCATTGCTGACCCAACCGCTTACATCGCC
TTAGATTCTCAAATTGAACAAGAAGCCAAACAGCGTTGCTTCACAAATTATTTACCGGGCTTTAACATTCCAATGTTACC
CCGTGAATTATCCGATGAATTATGTTCCTTAATCGCCAATGAAACCCGCCCCGCACTTGTCTGTTATATCGAAACCGATC
TTGCAGGCAACATCACAGCCAAACCGAATTTTGTTTCCGCTTATGTACAATCTAAAGCCAAACTGGCTTACAACAAAGTC
TCAGATTATTTAGAACAGGCAGACAATGCATGGCAGCCAGAAATGCCAGAAATTGCACAACAAATTCACTGGCTACATCA
ATTTACCAAAGCTCGCATTCAATGGCGCAAAACCCATTCCTTATTCTTTAAAGAAAAACCAGATTATACCTTTGTGCTGG
CAGAAAACGGCAAAGTGCAAGAAATCAAAGCAGAATATCGCCGCATTGCCAATCAAATTGTGGAAGAAGCAATGATTATT
GCCAACATCTGTGCCGCCCAATTTTTACACGAACAGGCAAAAACAGGCATTTTCAACACCCATAGCGGTTTTGATAAAAA
ATTCTTAGAGAACGCACACAATTTCTTAATGGCAAATTTAGCCAATGAACAAAATCAAACTGAACTGGCAGAACGTTATT
CAGTAGAAAACTTAGCAACTTTAAACGGCTATTGCCAAATGCGCCACGATATTGAACCCATCGAAAGCGATTATTTAGAA
CTGCGTTTACGCCGTTATTTAACTTTCGCCGAATTTAAATCAGAATTAGCACCGCACTTTGGGCTGGGGCTAGAGGGTTA
CGCCACTTGGACATCGCCCATCCGCAAATATTCAGATATGGTTAATCATCGCTTAATCAAAGCCGTGCTGGCAAAACAGC
CTTATGAAAAACCACAAAATGACGTGTTGGCACGTTTGCAAGAGGCTCGCCGCCAAAATCGCCTCGTAGAACGTGATATT
GCCGATTGGCTATATTGCCGTTATCTTGCTGATAAAGTGGCATCAAATGCTGAATTTGAGGCGGAAGTGCAAGATGTAAT
GCGTGCAGGCTTACGCGTACAACTGCTCGAAAATGGTGCATCGCTATTTATTCCTGCCGCCACGCTGCACAACAACAAAG
AAGAAATACAACTAAACCCTGACGAACTCGCCCTCTATATAAAAGGCGACCGCACTTACAAAATAGGCGACATTGTGAAA
GTGAAACTCACAGAAGTGAAAGAAGCAACTCGCAGTATTGTGGGCGAAATACTTCAATAA

Upstream 100 bases:

>100_bases
GAATTAGGCGAAGAATAATTTTTCTTACATTCTTTTTTTAGGCAGGCTTTTCAGTCTGCCTTTTCGCTTTTTTAAAATAT
AACGATGTTTCAAAATAACT

Downstream 100 bases:

>100_bases
ATTGCCGTTCCAATATGTTACGGAAGACGGCAAAACCGTTGTGAAAGTGGGCAATGAGTATTACGAAGCCAAGCAAGATG
GTTCGGCGGATATGGCTAAA

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIKATIEKQGDKEQAEPESLIEP
MLTRFIAKVRFNKDKKLQVLVDHPNINQPIGAQQAKSVKEELQEGDWVVANLKTHPLRDDRFFYATINQFICRAEDELAP
WWVTLARHEQSRYPVRGAEPYEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLAGNITAKPNFVSAYVQSKAKLAYNKV
SDYLEQADNAWQPEMPEIAQQIHWLHQFTKARIQWRKTHSLFFKEKPDYTFVLAENGKVQEIKAEYRRIANQIVEEAMII
ANICAAQFLHEQAKTGIFNTHSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQNDVLARLQEARRQNRLVERDI
ADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGASLFIPAATLHNNKEEIQLNPDELALYIKGDRTYKIGDIVK
VKLTEVKEATRSIVGEILQ

Sequences:

>Translated_659_residues
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIKATIEKQGDKEQAEPESLIEP
MLTRFIAKVRFNKDKKLQVLVDHPNINQPIGAQQAKSVKEELQEGDWVVANLKTHPLRDDRFFYATINQFICRAEDELAP
WWVTLARHEQSRYPVRGAEPYEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLAGNITAKPNFVSAYVQSKAKLAYNKV
SDYLEQADNAWQPEMPEIAQQIHWLHQFTKARIQWRKTHSLFFKEKPDYTFVLAENGKVQEIKAEYRRIANQIVEEAMII
ANICAAQFLHEQAKTGIFNTHSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQNDVLARLQEARRQNRLVERDI
ADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGASLFIPAATLHNNKEEIQLNPDELALYIKGDRTYKIGDIVK
VKLTEVKEATRSIVGEILQ
>Mature_659_residues
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIKATIEKQGDKEQAEPESLIEP
MLTRFIAKVRFNKDKKLQVLVDHPNINQPIGAQQAKSVKEELQEGDWVVANLKTHPLRDDRFFYATINQFICRAEDELAP
WWVTLARHEQSRYPVRGAEPYEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLAGNITAKPNFVSAYVQSKAKLAYNKV
SDYLEQADNAWQPEMPEIAQQIHWLHQFTKARIQWRKTHSLFFKEKPDYTFVLAENGKVQEIKAEYRRIANQIVEEAMII
ANICAAQFLHEQAKTGIFNTHSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQNDVLARLQEARRQNRLVERDI
ADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGASLFIPAATLHNNKEEIQLNPDELALYIKGDRTYKIGDIVK
VKLTEVKEATRSIVGEILQ

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=352, Percent_Identity=25.8522727272727, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI190014623, Length=352, Percent_Identity=25.8522727272727, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI134288890, Length=438, Percent_Identity=23.972602739726, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1787542, Length=657, Percent_Identity=49.3150684931507, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=676, Percent_Identity=27.2189349112426, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17553506, Length=487, Percent_Identity=23.6139630390144, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI212645896, Length=470, Percent_Identity=24.0425531914894, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324552, Length=432, Percent_Identity=23.8425925925926, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24649634, Length=367, Percent_Identity=25.6130790190736, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922976, Length=447, Percent_Identity=24.8322147651007, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24654597, Length=447, Percent_Identity=24.8322147651007, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24654592, Length=447, Percent_Identity=24.8322147651007, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 75831; Mature: 75831

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIK
CCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHCEEEEECCEEEEECCCHHHHHHCCCHHE
ATIEKQGDKEQAEPESLIEPMLTRFIAKVRFNKDKKLQVLVDHPNINQPIGAQQAKSVKE
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
ELQEGDWVVANLKTHPLRDDRFFYATINQFICRAEDELAPWWVTLARHEQSRYPVRGAEP
HHHCCCEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCH
YEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCEEEE
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLAGNITA
ECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
KPNFVSAYVQSKAKLAYNKVSDYLEQADNAWQPEMPEIAQQIHWLHQFTKARIQWRKTHS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFFKEKPDYTFVLAENGKVQEIKAEYRRIANQIVEEAMIIANICAAQFLHEQAKTGIFNT
HHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVLARLQEARRQNRLVERDIADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCC
SLFIPAATLHNNKEEIQLNPDELALYIKGDRTYKIGDIVKVKLTEVKEATRSIVGEILQ
CEEEEHHHHCCCCCCEEECHHHEEEEEECCCEEEECCEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIK
CCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHCEEEEECCEEEEECCCHHHHHHCCCHHE
ATIEKQGDKEQAEPESLIEPMLTRFIAKVRFNKDKKLQVLVDHPNINQPIGAQQAKSVKE
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
ELQEGDWVVANLKTHPLRDDRFFYATINQFICRAEDELAPWWVTLARHEQSRYPVRGAEP
HHHCCCEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCH
YEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCEEEE
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLAGNITA
ECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
KPNFVSAYVQSKAKLAYNKVSDYLEQADNAWQPEMPEIAQQIHWLHQFTKARIQWRKTHS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFFKEKPDYTFVLAENGKVQEIKAEYRRIANQIVEEAMIIANICAAQFLHEQAKTGIFNT
HHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVLARLQEARRQNRLVERDIADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCC
SLFIPAATLHNNKEEIQLNPDELALYIKGDRTYKIGDIVKVKLTEVKEATRSIVGEILQ
CEEEEHHHHCCCCCCEEECHHHEEEEEECCCEEEECCEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA