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The map label for this gene is csd [H]

Identifier: 148827009

GI number: 148827009

Start: 251281

End: 252480

Strand: Direct

Name: csd [H]

Synonym: CGSHiGG_01485

Alternate gene names: 148827009

Gene position: 251281-252480 (Clockwise)

Preceding gene: 148827008

Following gene: 148827010

Centisome position: 13.32

GC content: 41.17

Gene sequence:

>1200_bases
ATGGCTTTTGATTATCAAACGTTCCGTCAAGCATTTCCCTATTTCCAACGTGAAGATGCGGTTATTTATTTAGATAACGC
CGCCACCGCGTTGAAACCTCAAGTGTTAATTGATCGCACCGCTGAATTTTATGCGTCTGCAGGTTCGGTGCATCGCAGCC
AATATGATGCTGCCCAAACTGTGCAATATGAACAGGCTCGCACACAAGTAAAAGAATGGGTTAATGCAGAAGATAAACAC
GCTGTTATTTGGACTTCGGGTACAACTCACGCAATAAACTTAGTGGCAAATGGATTGCTGCCGCAATTAAACGCCGAAGA
TGAAATTCTGATTAGCCAAGCAGATCATCATGCCAATTTTGTCACTTGGCATGAAACGGCGAAAAAGTACGGTGGAAAAA
TTCGAGTTTTACCGATTTTAGATAATTGGCTAATTGATGAAAATGTGCTTATTTCTACCCTTTCTGAAAAAACAAAACTC
GTTGCGCTGAATTTTGTTTCAAATGTCACGGGCACAGAACAGCCGATTAAACGCCTGATTCAACTTATTAGAAAACATAG
TCATGCATTGGTTTTAGTAGATGCTGCACAAGCGATTAGTCATATCAAAATTGATTTACAAGATTTAGATGCCGATTTCC
TCGCATTTTCTGCCCATAAAATTTATGGTCCAAATGGGCTTGGCGTTTTAACAGGAAAATTGACCGCACTTTCTCAACTT
CAACCGCTCTTTTTTGGCGGGAAAATGGTTGAGCGTGTGTCAAATAATCGTATTACTTTTGCCGAATTACCTTATCGTTT
AGAAGCTGGCACACCCAATATTGCTGGGGTTATTGGCTTTAATGCTGTGCTGGATTGGCTACAAAAATGGGATTTTACCG
CAGCAGAACAGCACGCTATATCCTTGGCTGAATCCGTCAAAGTGCGGTTAAAATCTTACGAGAATTGCCGATTATTCAAT
TCCCCTCAAGCAAGCACTGTCGTTTGTTTTGTATTTGACGGCATTGACTGTTCCGATCTTTCTACACTTTTGAGCGAACA
AAATATTGCGCTCCGAGTGGGAGAACATTGTGCCCAGCCTTATTTAGCACGCTTAGGCGAACGCACCACATTACGTCTTT
CTTTTTCGCCTTATAATACGCAAAAAGATGTAGAGGCATTCTTCACCGCCTTAGATAAAGCACTGGATTTATTACAATGA

Upstream 100 bases:

>100_bases
CTTCAAGCGCAAGAAAATGCACAAGCCAAAGGAATTGGTCTTTGGGCAGACAATAATCCGATTGAACCAAGTCAATGGCG
CAGACAAGAGAAAAATTAAT

Downstream 100 bases:

>100_bases
TAGAACAATTACAACAAGCTAAAAATTGGGAAGATCGCTATCGCCTAATTATTCAAGCAGGCAAAAATTTACCTCGCCCA
AGCGATAATGAACTCGCTCA

Product: putative selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAFDYQTFRQAFPYFQREDAVIYLDNAATALKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQYEQARTQVKEWVNAEDKH
AVIWTSGTTHAINLVANGLLPQLNAEDEILISQADHHANFVTWHETAKKYGGKIRVLPILDNWLIDENVLISTLSEKTKL
VALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQL
QPLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRLKSYENCRLFN
SPQASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYLARLGERTTLRLSFSPYNTQKDVEAFFTALDKALDLLQ

Sequences:

>Translated_399_residues
MAFDYQTFRQAFPYFQREDAVIYLDNAATALKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQYEQARTQVKEWVNAEDKH
AVIWTSGTTHAINLVANGLLPQLNAEDEILISQADHHANFVTWHETAKKYGGKIRVLPILDNWLIDENVLISTLSEKTKL
VALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQL
QPLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRLKSYENCRLFN
SPQASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYLARLGERTTLRLSFSPYNTQKDVEAFFTALDKALDLLQ
>Mature_398_residues
AFDYQTFRQAFPYFQREDAVIYLDNAATALKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQYEQARTQVKEWVNAEDKHA
VIWTSGTTHAINLVANGLLPQLNAEDEILISQADHHANFVTWHETAKKYGGKIRVLPILDNWLIDENVLISTLSEKTKLV
ALNFVSNVTGTEQPIKRLIQLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQ
PLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAISLAESVKVRLKSYENCRLFNS
PQASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYLARLGERTTLRLSFSPYNTQKDVEAFFTALDKALDLLQ

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=342, Percent_Identity=25.1461988304094, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156713448, Length=267, Percent_Identity=25.0936329588015, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=46.3840399002494, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=35.9605911330049, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI48994898, Length=234, Percent_Identity=29.4871794871795, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=233, Percent_Identity=30.9012875536481, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=348, Percent_Identity=26.7241379310345, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319831, Length=393, Percent_Identity=28.2442748091603, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129463, Length=237, Percent_Identity=30.8016877637131, Blast_Score=108, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44597; Mature: 44466

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDYQTFRQAFPYFQREDAVIYLDNAATALKPQVLIDRTAEFYASAGSVHRSQYDAAQT
CCCCHHHHHHHCCCCCCCCCEEEECCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
VQYEQARTQVKEWVNAEDKHAVIWTSGTTHAINLVANGLLPQLNAEDEILISQADHHANF
HHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCE
VTWHETAKKYGGKIRVLPILDNWLIDENVLISTLSEKTKLVALNFVSNVTGTEQPIKRLI
EEHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHH
QLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQL
HHHHCCCCEEEEEEHHHHHHHEEEEHHHCCCHHHEEEHHEEECCCCCEEEEHHHHHHHHC
QPLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAI
CHHHHCHHHHHHHCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
SLAESVKVRLKSYENCRLFNSPQASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQP
HHHHHHHHHHHCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEHHHHHCCH
YLARLGERTTLRLSFSPYNTQKDVEAFFTALDKALDLLQ
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFDYQTFRQAFPYFQREDAVIYLDNAATALKPQVLIDRTAEFYASAGSVHRSQYDAAQT
CCCHHHHHHHCCCCCCCCCEEEECCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
VQYEQARTQVKEWVNAEDKHAVIWTSGTTHAINLVANGLLPQLNAEDEILISQADHHANF
HHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCE
VTWHETAKKYGGKIRVLPILDNWLIDENVLISTLSEKTKLVALNFVSNVTGTEQPIKRLI
EEHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHH
QLIRKHSHALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQL
HHHHCCCCEEEEEEHHHHHHHEEEEHHHCCCHHHEEEHHEEECCCCCEEEEHHHHHHHHC
QPLFFGGKMVERVSNNRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQHAI
CHHHHCHHHHHHHCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
SLAESVKVRLKSYENCRLFNSPQASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQP
HHHHHHHHHHHCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEHHHHHCCH
YLARLGERTTLRLSFSPYNTQKDVEAFFTALDKALDLLQ
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]