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The map label for this gene is ribH

Identifier: 148827001

GI number: 148827001

Start: 243137

End: 243610

Strand: Reverse

Name: ribH

Synonym: CGSHiGG_01445

Alternate gene names: 148827001

Gene position: 243610-243137 (Counterclockwise)

Preceding gene: 148827004

Following gene: 148827000

Centisome position: 12.91

GC content: 40.08

Gene sequence:

>474_bases
ATGAAAGTTTTAGAAGGCTCAGTCGCAGCACCTAATGCAAAAGTTGCAGTAGCAATTGCTCGTTTTAACAGTTTTATTAA
TGAAAGTTTATTAGAAGGTGCAATTGACGCATTAAAACGTATTGGCCAAGTGAAAGATGAAAATATCACTATCGTGCGTA
CCCCGGGCGCGTATGAGTTGCCATTAGTTGCTCGTCGTTTAGCTGAAAGTAAAAAATTTGATGCGATTGTGGCATTAGGT
ACAGTTATCCGTGGTGGTACAGCACATTTTGAATATGTAGCAGGAGAAGCAAGCAGCGGTTTAGGAAAAGTTGCAATGGA
TGCTGAAATCCCTGTCGCTTTTGGTGTATTAACCACAGAAAATATTGAACAGGCGATTGAACGTGCTGGTACTAAAGCAG
GAAATAAAGGTGCAGAAGCAGCCTTAACTGCACTTGAAATGGTTAATCTTATTCAACAAATTGATGCGGCATAA

Upstream 100 bases:

>100_bases
GTCCTAAATAAAATAGGGTAAAGCCTTATTAATATTGAATATACGTGATTTTATGCTAAAATCTCGGGTCAAAATCATTA
TGGCTAATAATAGGAAAAAT

Downstream 100 bases:

>100_bases
ATCATGACAGAACAAAAACAAGTGAAAAAGCCTTCTGCTCGTCGTCGTGCGCGTGAGTGTACTGTTCAAGCCTTGTATTC
TTGGGCGGTATCCGGTAATA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKVLEGSVAAPNAKVAVAIARFNSFINESLLEGAIDALKRIGQVKDENITIVRTPGAYELPLVARRLAESKKFDAIVALG
TVIRGGTAHFEYVAGEASSGLGKVAMDAEIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALTALEMVNLIQQIDAA

Sequences:

>Translated_157_residues
MKVLEGSVAAPNAKVAVAIARFNSFINESLLEGAIDALKRIGQVKDENITIVRTPGAYELPLVARRLAESKKFDAIVALG
TVIRGGTAHFEYVAGEASSGLGKVAMDAEIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALTALEMVNLIQQIDAA
>Mature_157_residues
MKVLEGSVAAPNAKVAVAIARFNSFINESLLEGAIDALKRIGQVKDENITIVRTPGAYELPLVARRLAESKKFDAIVALG
TVIRGGTAHFEYVAGEASSGLGKVAMDAEIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALTALEMVNLIQQIDAA

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=156, Percent_Identity=76.2820512820513, Blast_Score=244, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324429, Length=155, Percent_Identity=33.5483870967742, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_HAEI8 (Q4QKN2)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_249075.1
- HSSP:   Q9XH32
- ProteinModelPortal:   Q4QKN2
- SMR:   Q4QKN2
- STRING:   Q4QKN2
- GeneID:   3430852
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI1616
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- PhylomeDB:   Q4QKN2
- ProtClustDB:   PRK00061
- BioCyc:   HINF281310:NTHI1616-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16391; Mature: 16391

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLEGSVAAPNAKVAVAIARFNSFINESLLEGAIDALKRIGQVKDENITIVRTPGAYEL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
PLVARRLAESKKFDAIVALGTVIRGGTAHFEYVAGEASSGLGKVAMDAEIPVAFGVLTTE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCCCEEEEHCCHH
NIEQAIERAGTKAGNKGAEAALTALEMVNLIQQIDAA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVLEGSVAAPNAKVAVAIARFNSFINESLLEGAIDALKRIGQVKDENITIVRTPGAYEL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
PLVARRLAESKKFDAIVALGTVIRGGTAHFEYVAGEASSGLGKVAMDAEIPVAFGVLTTE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCCCEEEEHCCHH
NIEQAIERAGTKAGNKGAEAALTALEMVNLIQQIDAA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA