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The map label for this gene is pntB [H]

Identifier: 148826834

GI number: 148826834

Start: 88026

End: 89450

Strand: Direct

Name: pntB [H]

Synonym: CGSHiGG_00470

Alternate gene names: 148826834

Gene position: 88026-89450 (Clockwise)

Preceding gene: 148826833

Following gene: 148826835

Centisome position: 4.66

GC content: 41.75

Gene sequence:

>1425_bases
ATGTCTGAAGGTTTAGTACAGGCTGCGTATATTTTAGCAGCATTACTTTTCATTATGAGCTTGGCAGGACTTTCTAAACA
TGAAACTGCTAAAGCGGGTTGTTGGTTCGGTATTGTTGGTATGACAATTGCCCTTATCGCAACCATTTTTGGCCCTCATT
CTGAAGGAACATTTTGGATCATTATTGCGATGATCATCGGTGGTGCAATCGGTGTTCAACGTGCATTAAAAGTAGAAATG
ACTGAAATGCCAGAACTTGTGGCGATTCTTCACAGTTTCGTTGGTTTAGCGGCTGTACTCGTTGGCTTTAATAGCTATGG
TTTACACCATGAGGCATTAATGCCAGAAGGGTTAGATGCAGCAGCACAAGCCGCATTTGTAGCTGAACAAGCAGTATTAA
CGAATATTCATAATGTTGAAGTATTTTTAGGTATTTTTATCGGTGCCGTAACTTTCACTGGTTCTGTTGTCGCATTTGGT
AAATTAAGCGGAAAAATTAATTCAAAAGCATTAATGTTACCGCATCGCCATAAATTAAATTTAGCCGCACTTGTGGTATC
TGCATTATTGATGGTTGCATTCTTGAATAATCCAGAAAGCATTTTCCCTGTGTTATTAATGACAGCGATTGCGCTTGCAT
TTGGATGGCACTTAGTGGCATCAATCGGTGGGGCAGATATGCCAGTTGTGGTATCAATGCTTAACTCATATTCTGGTTGG
GCAGCAGCTGCAGCAGGTTTTATGTTGAATAATGATTTGCTCATCGTTACAGGTGCGCTTGTTGGTTCTTCTGGTGCAAT
TCTTTCTTACATTATGTGTAAAGCGATGAACCGTTCATTTGTGAGCGTCATTGCTGGTGGTTTTGGTAACGATGTTCAAG
TTTCTTCAAGCGAAGAACAAGGCGAACACCGTGAAACTACAGCGGAAGAAGTGGCTGAATTGTTGAAAAATGCAAGTTCT
GTGATTATCACGCCGGGATATGGTATGGCTGTTGCACAAGCACAATATCCAGTCGCTGATATTACGGCAAAATTGCGTGA
ACGTGGTGTGAACGTTCGTTTTGGTATTCACCCTGTTGCAGGACGTTTACCGGGCCACATGAACGTGCTTTTAGCTGAAG
CGAAAGTACCTTACGATGTCGTACTTGAAATGGATGAAATCAATGATGATTTCGCTGATACCGATGTGGTATTGGTTATC
GGTGCGAACGATACGGTAAACCCAGCTGCGATGGAAGATCCAAATAGCCCAATTGCGGGAATGCCTGTGTTGGAAGTATG
GAAAGCACAAAATGTGATTGTGTTCAAACGTTCAATGGCAGTGGGTTACGCTGGCGTACAAAACCCATTATTCTTCAAAG
AGAATACGCAAATGCTCTTTGGTGATGCAAAAGATCGCGTTGAAGATATCTTAAAAGCATTATAA

Upstream 100 bases:

>100_bases
GCTTTTGTGGCGATTTTGGTGGCAAGCATCAATATTTTTGGTGGTTTCCGTGTCACACAACGTATGTTAGCAATGTTTAG
AAAAGGTTAAGGAGCGCACA

Downstream 100 bases:

>100_bases
AAAACACGCATAAAAATAACCGCACTTTGGGTTGCTTAAGTGCGGTATTTTTATTTATAGCATTTAAATATTATCTTCAT
GATTTTCCAAAATTTCTGAA

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSEGLVQAAYILAALLFIMSLAGLSKHETAKAGCWFGIVGMTIALIATIFGPHSEGTFWIIIAMIIGGAIGVQRALKVEM
TEMPELVAILHSFVGLAAVLVGFNSYGLHHEALMPEGLDAAAQAAFVAEQAVLTNIHNVEVFLGIFIGAVTFTGSVVAFG
KLSGKINSKALMLPHRHKLNLAALVVSALLMVAFLNNPESIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
AAAAAGFMLNNDLLIVTGALVGSSGAILSYIMCKAMNRSFVSVIAGGFGNDVQVSSSEEQGEHRETTAEEVAELLKNASS
VIITPGYGMAVAQAQYPVADITAKLRERGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDVVLVI
GANDTVNPAAMEDPNSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKDRVEDILKAL

Sequences:

>Translated_474_residues
MSEGLVQAAYILAALLFIMSLAGLSKHETAKAGCWFGIVGMTIALIATIFGPHSEGTFWIIIAMIIGGAIGVQRALKVEM
TEMPELVAILHSFVGLAAVLVGFNSYGLHHEALMPEGLDAAAQAAFVAEQAVLTNIHNVEVFLGIFIGAVTFTGSVVAFG
KLSGKINSKALMLPHRHKLNLAALVVSALLMVAFLNNPESIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
AAAAAGFMLNNDLLIVTGALVGSSGAILSYIMCKAMNRSFVSVIAGGFGNDVQVSSSEEQGEHRETTAEEVAELLKNASS
VIITPGYGMAVAQAQYPVADITAKLRERGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDVVLVI
GANDTVNPAAMEDPNSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKDRVEDILKAL
>Mature_473_residues
SEGLVQAAYILAALLFIMSLAGLSKHETAKAGCWFGIVGMTIALIATIFGPHSEGTFWIIIAMIIGGAIGVQRALKVEMT
EMPELVAILHSFVGLAAVLVGFNSYGLHHEALMPEGLDAAAQAAFVAEQAVLTNIHNVEVFLGIFIGAVTFTGSVVAFGK
LSGKINSKALMLPHRHKLNLAALVVSALLMVAFLNNPESIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGWA
AAAAGFMLNNDLLIVTGALVGSSGAILSYIMCKAMNRSFVSVIAGGFGNDVQVSSSEEQGEHRETTAEEVAELLKNASSV
IITPGYGMAVAQAQYPVADITAKLRERGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDVVLVIG
ANDTVNPAAMEDPNSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKDRVEDILKAL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=474, Percent_Identity=50.42194092827, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI122939153, Length=474, Percent_Identity=50.42194092827, Blast_Score=449, Evalue=1e-126,
Organism=Escherichia coli, GI1787886, Length=478, Percent_Identity=78.0334728033473, Blast_Score=728, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=471, Percent_Identity=48.619957537155, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 50181; Mature: 50050

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGLVQAAYILAALLFIMSLAGLSKHETAKAGCWFGIVGMTIALIATIFGPHSEGTFWI
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
IIAMIIGGAIGVQRALKVEMTEMPELVAILHSFVGLAAVLVGFNSYGLHHEALMPEGLDA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCH
AAQAAFVAEQAVLTNIHNVEVFLGIFIGAVTFTGSVVAFGKLSGKINSKALMLPHRHKLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCH
LAALVVSALLMVAFLNNPESIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
AAAAAGFMLNNDLLIVTGALVGSSGAILSYIMCKAMNRSFVSVIAGGFGNDVQVSSSEEQ
HHHHHHHEECCCEEEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEEECCCHHC
GEHRETTAEEVAELLKNASSVIITPGYGMAVAQAQYPVADITAKLRERGVNVRFGIHPVA
CCHHHHHHHHHHHHHHCCCCEEEECCCCCEEHHCCCCHHHHHHHHHHCCCCEEEECCHHC
GRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDVVLVIGANDTVNPAAMEDPNSPIAG
CCCCCCCEEEEECCCCCHHHEEEHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
MPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKDRVEDILKAL
CCHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHC
>Mature Secondary Structure 
SEGLVQAAYILAALLFIMSLAGLSKHETAKAGCWFGIVGMTIALIATIFGPHSEGTFWI
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
IIAMIIGGAIGVQRALKVEMTEMPELVAILHSFVGLAAVLVGFNSYGLHHEALMPEGLDA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCH
AAQAAFVAEQAVLTNIHNVEVFLGIFIGAVTFTGSVVAFGKLSGKINSKALMLPHRHKLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCH
LAALVVSALLMVAFLNNPESIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
AAAAAGFMLNNDLLIVTGALVGSSGAILSYIMCKAMNRSFVSVIAGGFGNDVQVSSSEEQ
HHHHHHHEECCCEEEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEEECCCHHC
GEHRETTAEEVAELLKNASSVIITPGYGMAVAQAQYPVADITAKLRERGVNVRFGIHPVA
CCHHHHHHHHHHHHHHCCCCEEEECCCCCEEHHCCCCHHHHHHHHHHCCCCEEEECCHHC
GRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDVVLVIGANDTVNPAAMEDPNSPIAG
CCCCCCCEEEEECCCCCHHHEEEHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
MPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKDRVEDILKAL
CCHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 8635745 [H]