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The map label for this gene is serA [C]

Identifier: 148826788

GI number: 148826788

Start: 25356

End: 26303

Strand: Direct

Name: serA [C]

Synonym: CGSHiGG_00175

Alternate gene names: 148826788

Gene position: 25356-26303 (Clockwise)

Preceding gene: 148826787

Following gene: 148826789

Centisome position: 1.34

GC content: 39.35

Gene sequence:

>948_bases
ATGAAAATCGTATTTTTAGATAGCACGGCTATTCCTAAACATATTTCAATTCCTCGCCCAAGTTTTGAACATACTTGGAC
TGAATATGATCATACGTCTTCTGCCGAAACCATTGAGCGAGCGAAAGATGCGGACATTGTTATTACCAGCAAAGTGATTT
TTGATCGTGAAACTTTGCAACAACTGCCAAAATTAAAGCTGATTGCCATTACTGCGACAGGTACAAATAATGTTGATCTT
GTGGCTGCAGAAGAAATGGGTATCGCCGTGCGTAATGTGACAGGTTATTCCAGTACAACCGTGCCAGAACACGTAATGGG
TCTGATTTTTTCTTTAAAACACAGTTTGGCAGGTTGGTTACGCGATCAAACGGAAGCAAAATGGGCGGAAAGTAAACAAT
TTTGTTATTTTGATTATCCAATTACAGATGTGCGCGGTTCAACGTTGGGTGTATTTGGTAAAGGTTGCCTAGGAACAGAA
GTGGGGCGTTTGGCTAATGCCGTGGGAATGAAAGTACTTTATGCAGAACATAAAGATGCTACTGTTTGCCGTGAAGGTTA
TACGCCCTTTGATGAAGTATTAAAACAAGCGGATATTGTGACGTTGCATTGCCCATTAACGGAAACAACAAAGAATTTAA
TTAATACAGAAACCTTATCCAAAATGAAAAAAGGTGCATTTTTGATTAATACAGGGCGTGGGCCTTTGATTGATGAACTT
GCCTTAGTTGATGCGTTAAAAACGAGGCATTTAGGCGGAGCGGCTTTGGATGTAATGGTAAAAGAGCCACCAGAAAAAGA
TAATCCGTTAATTTTAGCTGCAAAAACGATGCCTAATTTAATTATCACCCCGCATATTGCTTGGGCGAGCGATAGTGCAG
TGACAACATTAGTTGGCAAAGTAATGCAAAACATCGAAGAATTTGTACAACAATTACATCAAAAATAA

Upstream 100 bases:

>100_bases
ATTTAGTAAAATCTTTTCCAGAATTGGATACCTCAATTTAAATTTCATCAAAAGTGCGGTTAATTTTGACCGCACTTTGT
ATATAAAAAAGGAGCAATTA

Downstream 100 bases:

>100_bases
TGAATTTTCCTATTTCTCTTTATATTGCACTACGTTATTGGCGTGCGAAAAGTGCGGATCGTTTTGGGCGATTAGTGACT
AATCTTGCAAGCCTGGGGAT

Product: glycerate dehydrogenase

Products: 3-Phosphohydroxypyruvate; H+; Nicotinamide adenine dinucleotide - reduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKIVFLDSTAIPKHISIPRPSFEHTWTEYDHTSSAETIERAKDADIVITSKVIFDRETLQQLPKLKLIAITATGTNNVDL
VAAEEMGIAVRNVTGYSSTTVPEHVMGLIFSLKHSLAGWLRDQTEAKWAESKQFCYFDYPITDVRGSTLGVFGKGCLGTE
VGRLANAVGMKVLYAEHKDATVCREGYTPFDEVLKQADIVTLHCPLTETTKNLINTETLSKMKKGAFLINTGRGPLIDEL
ALVDALKTRHLGGAALDVMVKEPPEKDNPLILAAKTMPNLIITPHIAWASDSAVTTLVGKVMQNIEEFVQQLHQK

Sequences:

>Translated_315_residues
MKIVFLDSTAIPKHISIPRPSFEHTWTEYDHTSSAETIERAKDADIVITSKVIFDRETLQQLPKLKLIAITATGTNNVDL
VAAEEMGIAVRNVTGYSSTTVPEHVMGLIFSLKHSLAGWLRDQTEAKWAESKQFCYFDYPITDVRGSTLGVFGKGCLGTE
VGRLANAVGMKVLYAEHKDATVCREGYTPFDEVLKQADIVTLHCPLTETTKNLINTETLSKMKKGAFLINTGRGPLIDEL
ALVDALKTRHLGGAALDVMVKEPPEKDNPLILAAKTMPNLIITPHIAWASDSAVTTLVGKVMQNIEEFVQQLHQK
>Mature_315_residues
MKIVFLDSTAIPKHISIPRPSFEHTWTEYDHTSSAETIERAKDADIVITSKVIFDRETLQQLPKLKLIAITATGTNNVDL
VAAEEMGIAVRNVTGYSSTTVPEHVMGLIFSLKHSLAGWLRDQTEAKWAESKQFCYFDYPITDVRGSTLGVFGKGCLGTE
VGRLANAVGMKVLYAEHKDATVCREGYTPFDEVLKQADIVTLHCPLTETTKNLINTETLSKMKKGAFLINTGRGPLIDEL
ALVDALKTRHLGGAALDVMVKEPPEKDNPLILAAKTMPNLIITPHIAWASDSAVTTLVGKVMQNIEEFVQQLHQK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=252, Percent_Identity=36.1111111111111, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4557497, Length=252, Percent_Identity=36.1111111111111, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI145580578, Length=252, Percent_Identity=36.1111111111111, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI4557499, Length=252, Percent_Identity=36.1111111111111, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI145580575, Length=276, Percent_Identity=34.4202898550725, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI23308577, Length=271, Percent_Identity=30.2583025830258, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI6912396, Length=238, Percent_Identity=26.4705882352941, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1789279, Length=258, Percent_Identity=31.3953488372093, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1787645, Length=266, Percent_Identity=30.4511278195489, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87082289, Length=292, Percent_Identity=30.1369863013699, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788660, Length=226, Percent_Identity=27.4336283185841, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=258, Percent_Identity=33.7209302325581, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=260, Percent_Identity=32.6923076923077, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=289, Percent_Identity=32.5259515570934, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=289, Percent_Identity=32.1799307958478, Blast_Score=138, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=266, Percent_Identity=31.203007518797, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=219, Percent_Identity=33.7899543378995, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=90, Percent_Identity=36.6666666666667, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24646446, Length=253, Percent_Identity=36.7588932806324, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646448, Length=253, Percent_Identity=36.7588932806324, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646452, Length=253, Percent_Identity=36.7588932806324, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646450, Length=253, Percent_Identity=36.7588932806324, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI62472511, Length=253, Percent_Identity=36.7588932806324, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19921140, Length=236, Percent_Identity=32.6271186440678, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=28.030303030303, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571528, Length=275, Percent_Identity=28.7272727272727, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45552429, Length=235, Percent_Identity=26.3829787234043, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585514, Length=238, Percent_Identity=26.890756302521, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=238, Percent_Identity=26.890756302521, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551003, Length=238, Percent_Identity=26.890756302521, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=235, Percent_Identity=26.3829787234043, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585516, Length=304, Percent_Identity=23.6842105263158, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: 1.1.1.95 [C]

Molecular weight: Translated: 34699; Mature: 34699

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFLDSTAIPKHISIPRPSFEHTWTEYDHTSSAETIERAKDADIVITSKVIFDRETLQ
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEHHHHCHHHHH
QLPKLKLIAITATGTNNVDLVAAEEMGIAVRNVTGYSSTTVPEHVMGLIFSLKHSLAGWL
HCCCEEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RDQTEAKWAESKQFCYFDYPITDVRGSTLGVFGKGCLGTEVGRLANAVGMKVLYAEHKDA
HHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCC
TVCREGYTPFDEVLKQADIVTLHCPLTETTKNLINTETLSKMKKGAFLINTGRGPLIDEL
HHHHCCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
ALVDALKTRHLGGAALDVMVKEPPEKDNPLILAAKTMPNLIITPHIAWASDSAVTTLVGK
HHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCCCCEEEECCEECCCCCHHHHHHHH
VMQNIEEFVQQLHQK
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIVFLDSTAIPKHISIPRPSFEHTWTEYDHTSSAETIERAKDADIVITSKVIFDRETLQ
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEHHHHCHHHHH
QLPKLKLIAITATGTNNVDLVAAEEMGIAVRNVTGYSSTTVPEHVMGLIFSLKHSLAGWL
HCCCEEEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RDQTEAKWAESKQFCYFDYPITDVRGSTLGVFGKGCLGTEVGRLANAVGMKVLYAEHKDA
HHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCC
TVCREGYTPFDEVLKQADIVTLHCPLTETTKNLINTETLSKMKKGAFLINTGRGPLIDEL
HHHHCCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
ALVDALKTRHLGGAALDVMVKEPPEKDNPLILAAKTMPNLIITPHIAWASDSAVTTLVGK
HHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCCCCEEEECCEECCCCCHHHHHHHH
VMQNIEEFVQQLHQK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-Phospho-D-glycerate; Nicotinamide adenine dinucleotide [C]

Specific reaction: 3-Phospho-D-glycerate + Nicotinamide adenine dinucleotide --> 3-Phosphohydroxypyruvate + H+ + Nicotinamide adenine dinucleotide - reduced [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]