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The map label for this gene is obgE

Identifier: 148826478

GI number: 148826478

Start: 1517397

End: 1518608

Strand: Direct

Name: obgE

Synonym: CGSHiEE_07645

Alternate gene names: 148826478

Gene position: 1517397-1518608 (Clockwise)

Preceding gene: 148826477

Following gene: 148826481

Centisome position: 83.69

GC content: 41.42

Gene sequence:

>1212_bases
ATGAAATTTATTGATGAATCCCTTATTCGAATTGAGGCTGGAGATGGTGGCAACGGTTGCGTAAGTTTCCGTCGAGAGAA
ATTTATACCGAAAGGAGGCCCTGACGGTGGTGACGGTGGCGATGGTGGCGATGTCTATTTACAGGCTGATGAAAACCTCA
ATACCTTAATTGACTACCGCTTTAATAAACGCTTTGCGGCAGAGCGCGGAGAGAATGGACGGAGTTCAGATTGTACAGGA
CGTCGCGGTAAAGATATTATTTTACCTGTTCCCGTAGGAACTCGCGCTATTGATAATGATACCAAAGAAACCTTGGGAGA
TTTAACCCAACACGGTCAAAAAATGTTGGTAGCCAAAGGCGGTTATCACGGGTTAGGAAATACCCGTTTCAAATCATCGG
TAAACCGTGCACCGCGTCAAAAAACAATGGGAACACCGGGTGAAAAACGCGATTTATTATTGGAATTAATGCTACTTGCT
GATGTGGGAATGCTCGGTTTTCCTAATGCAGGTAAATCCACTTTTATTCGTGCCGTTTCAGCCGCCAAACCAAAAGTTGC
AGATTATCCATTTACTACCTTAGTACCAAGTCTCGGTGTTGTGAAAGTAGATGACTCACACAGTTTCGTAGTGGCAGATA
TTCCTGGATTAATTGAGGGGGCTGCAGATGGTGCAGGGCTAGGAATTCGCTTTTTAAAACATTTAGAACGTTGTAGAGTG
CTTATTCATTTAGTCGATATTGCTCCAATTGATGGATCTAATCCAGCAGATAATGTCGCTATTATTGAATCTGAACTTTT
CCAATACAGTGAAAAATTATCAGAAAAGCCACGTTGGTTAGTATTCAATAAAATTGATACGATGAGCGATGAAGAAGCTG
AAGAGCGGGTTCGAGAAATCACTGAACAATTAGGTTGGGAAGAAGACTATTACCTGATTTCAGCTGCAACAGGGAAAAAT
GTTCCACCACTTTGTCGTGATATTATGGACTTTATCATAGCAAATCCACGCGAAGCTGAAACACAACAAGTTGCACCTGA
AGAAGTAAAATTCAAATGGGAAGATTATCATCAGGAACAACTAGCGGAGTATCAATTTGATGATGACGAAGATTGGGATG
ACGATTGGACTGAAGAAGATGATGACGAAGATTGGGATGATGATTGGACTGAAGAAGATGATGAAGGAATTGAGTTCATC
TATAAACCTTAA

Upstream 100 bases:

>100_bases
GCATTTGTTGTAGTATGCGGGGCAATTTTTATCCGCAATTGGACATAAATTATTACCGCATAAAACTCATTAAAGTGCGG
TTTATTTTGGAGAAGTTTGA

Downstream 100 bases:

>100_bases
GAAAGTCTAATTTTGTAAGCATTAAAACTTTAAAAGCACCTAAAACTTTTAGGTGCTTTTTGCTATCAATTAACGCTCAA
AAATTTCACAATCAGTAAAG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKFIDESLIRIEAGDGGNGCVSFRREKFIPKGGPDGGDGGDGGDVYLQADENLNTLIDYRFNKRFAAERGENGRSSDCTG
RRGKDIILPVPVGTRAIDNDTKETLGDLTQHGQKMLVAKGGYHGLGNTRFKSSVNRAPRQKTMGTPGEKRDLLLELMLLA
DVGMLGFPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVKVDDSHSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LIHLVDIAPIDGSNPADNVAIIESELFQYSEKLSEKPRWLVFNKIDTMSDEEAEERVREITEQLGWEEDYYLISAATGKN
VPPLCRDIMDFIIANPREAETQQVAPEEVKFKWEDYHQEQLAEYQFDDDEDWDDDWTEEDDDEDWDDDWTEEDDEGIEFI
YKP

Sequences:

>Translated_403_residues
MKFIDESLIRIEAGDGGNGCVSFRREKFIPKGGPDGGDGGDGGDVYLQADENLNTLIDYRFNKRFAAERGENGRSSDCTG
RRGKDIILPVPVGTRAIDNDTKETLGDLTQHGQKMLVAKGGYHGLGNTRFKSSVNRAPRQKTMGTPGEKRDLLLELMLLA
DVGMLGFPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVKVDDSHSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LIHLVDIAPIDGSNPADNVAIIESELFQYSEKLSEKPRWLVFNKIDTMSDEEAEERVREITEQLGWEEDYYLISAATGKN
VPPLCRDIMDFIIANPREAETQQVAPEEVKFKWEDYHQEQLAEYQFDDDEDWDDDWTEEDDDEDWDDDWTEEDDEGIEFI
YKP
>Mature_403_residues
MKFIDESLIRIEAGDGGNGCVSFRREKFIPKGGPDGGDGGDGGDVYLQADENLNTLIDYRFNKRFAAERGENGRSSDCTG
RRGKDIILPVPVGTRAIDNDTKETLGDLTQHGQKMLVAKGGYHGLGNTRFKSSVNRAPRQKTMGTPGEKRDLLLELMLLA
DVGMLGFPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVKVDDSHSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LIHLVDIAPIDGSNPADNVAIIESELFQYSEKLSEKPRWLVFNKIDTMSDEEAEERVREITEQLGWEEDYYLISAATGKN
VPPLCRDIMDFIIANPREAETQQVAPEEVKFKWEDYHQEQLAEYQFDDDEDWDDDWTEEDDDEDWDDDWTEEDDEGIEFI
YKP

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=322, Percent_Identity=40.9937888198758, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI111955139, Length=313, Percent_Identity=38.6581469648562, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI111955063, Length=150, Percent_Identity=42, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=33.8582677165354, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI58761500, Length=128, Percent_Identity=33.59375, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789574, Length=363, Percent_Identity=73.5537190082645, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=32.8125, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790615, Length=221, Percent_Identity=25.7918552036199, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=299, Percent_Identity=40.8026755852843, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=321, Percent_Identity=31.7757009345794, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17509631, Length=143, Percent_Identity=34.2657342657343, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=31.3559322033898, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=161, Percent_Identity=37.888198757764, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=32.5396825396825, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129375, Length=326, Percent_Identity=39.5705521472393, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=38.9067524115756, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24640873, Length=142, Percent_Identity=31.6901408450704, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640877, Length=142, Percent_Identity=31.6901408450704, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640875, Length=142, Percent_Identity=31.6901408450704, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=33.8582677165354, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_HAEIE (A5UDJ7)

Other databases:

- EMBL:   CP000671
- RefSeq:   YP_001291231.1
- ProteinModelPortal:   A5UDJ7
- SMR:   A5UDJ7
- STRING:   A5UDJ7
- GeneID:   5225471
- GenomeReviews:   CP000671_GR
- KEGG:   hip:CGSHiEE_07645
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- ProtClustDB:   PRK12298
- BioCyc:   HINF374930:CGSHIEE_07645-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 45091; Mature: 45091

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIDESLIRIEAGDGGNGCVSFRREKFIPKGGPDGGDGGDGGDVYLQADENLNTLIDYR
CCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHH
FNKRFAAERGENGRSSDCTGRRGKDIILPVPVGTRAIDNDTKETLGDLTQHGQKMLVAKG
HCCHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEECC
GYHGLGNTRFKSSVNRAPRQKTMGTPGEKRDLLLELMLLADVGMLGFPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVKVDDSHSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHH
LIHLVDIAPIDGSNPADNVAIIESELFQYSEKLSEKPRWLVFNKIDTMSDEEAEERVREI
HHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
TEQLGWEEDYYLISAATGKNVPPLCRDIMDFIIANPREAETQQVAPEEVKFKWEDYHQEQ
HHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHCCHHHHEEEHHHHHHHH
LAEYQFDDDEDWDDDWTEEDDDEDWDDDWTEEDDEGIEFIYKP
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MKFIDESLIRIEAGDGGNGCVSFRREKFIPKGGPDGGDGGDGGDVYLQADENLNTLIDYR
CCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHH
FNKRFAAERGENGRSSDCTGRRGKDIILPVPVGTRAIDNDTKETLGDLTQHGQKMLVAKG
HCCHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEECC
GYHGLGNTRFKSSVNRAPRQKTMGTPGEKRDLLLELMLLADVGMLGFPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVKVDDSHSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHH
LIHLVDIAPIDGSNPADNVAIIESELFQYSEKLSEKPRWLVFNKIDTMSDEEAEERVREI
HHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
TEQLGWEEDYYLISAATGKNVPPLCRDIMDFIIANPREAETQQVAPEEVKFKWEDYHQEQ
HHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHCCHHHHEEEHHHHHHHH
LAEYQFDDDEDWDDDWTEEDDDEDWDDDWTEEDDEGIEFIYKP
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA