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The map label for this gene is hemH [H]

Identifier: 148826229

GI number: 148826229

Start: 1238270

End: 1239226

Strand: Direct

Name: hemH [H]

Synonym: CGSHiEE_06250

Alternate gene names: 148826229

Gene position: 1238270-1239226 (Clockwise)

Preceding gene: 148826228

Following gene: 148826230

Centisome position: 68.3

GC content: 43.26

Gene sequence:

>957_bases
ATGTCAGATATCAAACACGCAAAACTTTTAATTTTAGGCTCAGGCCCTGCTGGTTATACAGCAGCCATTTATGCGGCACG
TGCAAACTTAAAACCAGTACTGGTGACTGGTTTGCAACAAGGTGGACAGCTGACTACCACAGATGAAATTGAGAACTGGC
CGGGCGATTTTGAGATGACTACTGGTTCAGGTTTAATGCAACGTATGTTGCAACATGCAGAAAAATTTGAAACAGAAATC
GTCTTCGATCATATCAATCGCGTAGATTTATCTTCTCGCCCATTCAAACTTTTTGGCGATGTGCAAAATTTCACTTGTGA
TGCGTTAATTATCGCAACGGGTGCCTCTGCACGTTATATTGGGTTGCCTTCAGAAGAAAACTACAAAGGCCGTGGGGTTT
CAGCTTGCGCAACCTGTGATGGTTTCTTTTATCGTAATAAGCCTGTTGGTGTCATTGGTGGTGGAAATACTGCGGTGGAA
GAAGCGCTTTACTTAGCCAATATTGCAAGTACAGTGCATTTAATCCACCGTCGCGATAGTTTCCGTGCGGAAAAAATCCT
TATCGATCGTTTATACAAAAAAGTAGAAGAAGGGAAAATCGTTCTTCATACTGACCGCACTTTAGATGAAGTATTGGGCG
ATAATATGGGCGTAACTGGATTACGTTTAGCCAACACAAAAACTGGGGAGAAAGAAGAACTCAAATTAGATGGCTTATTC
GTGGCGATTGGTCATTCGCCAAATACGCAAATTTTCCAAGGGCAACTAGAATTGAATAATGGCTATATCATTGTAAAATC
TGGTCTTGACGGCGATGCAACCGCCACTTCTGTGGAAGGCGTGTTCGCAGCTGGCGATGTCATGGATCACAATTATCGCC
AAGCCATTACCTCCGCAGGAACTGGTTGTATGGCAGCCTTGGATGCAGAACGCTATTTAGATGCTCAAGAAGCATAA

Upstream 100 bases:

>100_bases
CGATTGCTTTATTCGCTGCTTTATTAAGCAAAAAGTTTATAATCAGTAAAATGCAACTTATTGCATTATATTATTACTTA
ACTACAAACAAGGATTCTTT

Downstream 100 bases:

>100_bases
ATCTTCTAACCAATTCCCCTCTTTTAACTCTTTTAAAGAGGGGAACTTTTTCTATAATCACGACCAAAACAATGAATAAA
CTTCGCCAAAAATATTTACA

Product: ferrochelatase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMTTGSGLMQRMLQHAEKFETEI
VFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVE
EALYLANIASTVHLIHRRDSFRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
VAIGHSPNTQIFQGQLELNNGYIIVKSGLDGDATATSVEGVFAAGDVMDHNYRQAITSAGTGCMAALDAERYLDAQEA

Sequences:

>Translated_318_residues
MSDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMTTGSGLMQRMLQHAEKFETEI
VFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVE
EALYLANIASTVHLIHRRDSFRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
VAIGHSPNTQIFQGQLELNNGYIIVKSGLDGDATATSVEGVFAAGDVMDHNYRQAITSAGTGCMAALDAERYLDAQEA
>Mature_317_residues
SDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMTTGSGLMQRMLQHAEKFETEIV
FDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVEE
ALYLANIASTVHLIHRRDSFRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLFV
AIGHSPNTQIFQGQLELNNGYIIVKSGLDGDATATSVEGVFAAGDVMDHNYRQAITSAGTGCMAALDAERYLDAQEA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=315, Percent_Identity=75.8730158730159, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI87081763, Length=314, Percent_Identity=35.3503184713376, Blast_Score=141, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321898, Length=329, Percent_Identity=50.1519756838906, Blast_Score=296, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6320560, Length=326, Percent_Identity=50, Blast_Score=292, Evalue=5e-80,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34409; Mature: 34278

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMT
CCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEHHHHHCCCCCEEEE
TGSGLMQRMLQHAEKFETEIVFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEE
GLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVEEALYLANIASTVHLIHRRDS
ECCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
FRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
HHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCCEEEEECCCCCCHHEEEEEEEE
VAIGHSPNTQIFQGQLELNNGYIIVKSGLDGDATATSVEGVFAAGDVMDHNYRQAITSAG
EEECCCCCCEEEEEEEEECCCEEEEECCCCCCCCCEECCCEEEECCHHCCHHHHHHHHCC
TGCMAALDAERYLDAQEA
CCCEEECCHHHHCCCCCC
>Mature Secondary Structure 
SDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQLTTTDEIENWPGDFEMT
CCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEHHHHHCCCCCEEEE
TGSGLMQRMLQHAEKFETEIVFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEE
GLPSEENYKGRGVSACATCDGFFYRNKPVGVIGGGNTAVEEALYLANIASTVHLIHRRDS
ECCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
FRAEKILIDRLYKKVEEGKIVLHTDRTLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLF
HHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCCEEEEECCCCCCHHEEEEEEEE
VAIGHSPNTQIFQGQLELNNGYIIVKSGLDGDATATSVEGVFAAGDVMDHNYRQAITSAG
EEECCCCCCEEEEEEEEECCCEEEEECCCCCCCCCEECCCEEEECCHHCCHHHHHHHHCC
TGCMAALDAERYLDAQEA
CCCEEECCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]