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The map label for this gene is hemH [H]

Identifier: 148826227

GI number: 148826227

Start: 1236288

End: 1237259

Strand: Direct

Name: hemH [H]

Synonym: CGSHiEE_06240

Alternate gene names: 148826227

Gene position: 1236288-1237259 (Clockwise)

Preceding gene: 148826226

Following gene: 148826228

Centisome position: 68.19

GC content: 38.07

Gene sequence:

>972_bases
ATGACAAAATCCGCAAAAATCGGCGTATTACTTGCCAATCTAGGCACGCCAGATAGCCCAACACCGAAGTCAATCAGCCG
TTATTTATGGCAATTTTTAACGGATCCTCGCGTGGTAGATTTACCCCGTTGCAAATGGTATCCACTGCTTAAAGCCATTA
TTTTACCATTGCGTTCAAAACGTATCGCCAAAAATTATCAAGCAATCTGGACAGAACAAGGTTCGCCTTTACTTGCCATT
TCACGACAACAAAAAGACGCATTACAAGCCTATTTAGATACGCAAAATATCAATGCTCAAGTAGAAATTGCCATGACGTA
CGGCAATCCATCAATACAAAGTGCGGTGAAGAACTTGCTTAAAAATCAAGTTGAGCGAATTATTGTTTTGCCTCTTTATC
CGCAATACTCTAGCTCAACCACGGGCGCAGTATTTGATGCTTTCGCTAATGCCCTTAAAGAAGAACGAGGATTAGTGCCT
TTTGATTTCATCCATTCTTATCATATTGATGAAAATTACATTAACGCCTTAGCAAACTCCATAAAAGTGAGGTTAAAATC
TGATGAGTTTTTACTATTTTCTTATCACGGTATTCCTCTGCGTTATGAAAAAATGGGCGATTATTATCGTGAACATTGTA
AACAAACGACTATTGCAGTTGTTAATAAGCTAGGCTTAACAGAAAACCAATGGGGAATGACGTTTCAATCGCGCTTTGGG
CGTGAAGAATGGCTACAGCCTTACACCGATAAATTTTTAGAATCAGCTGCAACACAGAACATTCAAAAAATTGCCGTTAT
TTGCCCGGGTTTCTCCGTAGATTGTTTAGAAACCATTGAAGAAATTGACAAAGAAAATCGAGAAAATTTTCTAAAAAATG
GCGGGCAATCTTATCAATATATTCCCGCACTTAATGTAGAGCATGCACATATTGAAATGATGGGAAAATTGATCCTAGAA
AAACTTGCTTAA

Upstream 100 bases:

>100_bases
TTAATTTGGGCAGAAATATCCAAGTTTGGCAAATTGACATCCGCACAGAAGAGAATAAACTTTGTTGTGTTTCTAGATTA
ACCCTTTCCGTAATCAATTT

Downstream 100 bases:

>100_bases
TAATCGAAATGGTAAAACGTTTCTAAAATCTTCCGCACTTTGCTAAAATCAGCCATTATTTTTTTCACAAGGATAAAACA
TGGCTGATTTTCCTTTTATC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTKSAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSKRIAKNYQAIWTEQGSPLLAI
SRQQKDALQAYLDTQNINAQVEIAMTYGNPSIQSAVKNLLKNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLVP
FDFIHSYHIDENYINALANSIKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWGMTFQSRFG
REEWLQPYTDKFLESAATQNIQKIAVICPGFSVDCLETIEEIDKENRENFLKNGGQSYQYIPALNVEHAHIEMMGKLILE
KLA

Sequences:

>Translated_323_residues
MTKSAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSKRIAKNYQAIWTEQGSPLLAI
SRQQKDALQAYLDTQNINAQVEIAMTYGNPSIQSAVKNLLKNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLVP
FDFIHSYHIDENYINALANSIKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWGMTFQSRFG
REEWLQPYTDKFLESAATQNIQKIAVICPGFSVDCLETIEEIDKENRENFLKNGGQSYQYIPALNVEHAHIEMMGKLILE
KLA
>Mature_322_residues
TKSAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSKRIAKNYQAIWTEQGSPLLAIS
RQQKDALQAYLDTQNINAQVEIAMTYGNPSIQSAVKNLLKNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLVPF
DFIHSYHIDENYINALANSIKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWGMTFQSRFGR
EEWLQPYTDKFLESAATQNIQKIAVICPGFSVDCLETIEEIDKENRENFLKNGGQSYQYIPALNVEHAHIEMMGKLILEK
LA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=305, Percent_Identity=25.2459016393443, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI60499025, Length=305, Percent_Identity=25.2459016393443, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786681, Length=319, Percent_Identity=50.7836990595611, Blast_Score=326, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=25.1479289940828, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17864156, Length=305, Percent_Identity=24.9180327868852, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=25.7692307692308, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36916; Mature: 36785

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSK
CCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHH
RIAKNYQAIWTEQGSPLLAISRQQKDALQAYLDTQNINAQVEIAMTYGNPSIQSAVKNLL
HHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHH
KNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLVPFDFIHSYHIDENYINALANS
HHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHH
IKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWGMTFQSRFG
HEEEEECCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
REEWLQPYTDKFLESAATQNIQKIAVICPGFSVDCLETIEEIDKENRENFLKNGGQSYQY
HHHHCCHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IPALNVEHAHIEMMGKLILEKLA
ECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKSAKIGVLLANLGTPDSPTPKSISRYLWQFLTDPRVVDLPRCKWYPLLKAIILPLRSK
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHH
RIAKNYQAIWTEQGSPLLAISRQQKDALQAYLDTQNINAQVEIAMTYGNPSIQSAVKNLL
HHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHH
KNQVERIIVLPLYPQYSSSTTGAVFDAFANALKEERGLVPFDFIHSYHIDENYINALANS
HHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHH
IKVRLKSDEFLLFSYHGIPLRYEKMGDYYREHCKQTTIAVVNKLGLTENQWGMTFQSRFG
HEEEEECCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
REEWLQPYTDKFLESAATQNIQKIAVICPGFSVDCLETIEEIDKENRENFLKNGGQSYQY
HHHHCCHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IPALNVEHAHIEMMGKLILEKLA
ECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA