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The map label for this gene is aroA

Identifier: 148826109

GI number: 148826109

Start: 1106413

End: 1107711

Strand: Direct

Name: aroA

Synonym: CGSHiEE_05550

Alternate gene names: 148826109

Gene position: 1106413-1107711 (Clockwise)

Preceding gene: 148826108

Following gene: 148826110

Centisome position: 61.03

GC content: 39.34

Gene sequence:

>1299_bases
ATGGAAAAAATTACTCTTGCACCAATAAGTGCGGTTGAAGGAACAATTAATTTACCAGGTTCTAAAAGTTTATCGAATCG
CGCATTACTTTTAGCCGCCTTAGCTAAAGGAACAACAAAAGTAACCAATTTATTAGATAGCGATGATATTCGACATATGC
TTAACGCCCTCAAAGCATTAGGCGTACGCTATCAACTGTCTGATGATAAAACTATTTGTGAAGTAGAAGGATTAGGTGGA
ACATTCAATATACAGGACAATCTTTCACTCTTTCTTGGCAATGCTGGGACTGCAATGCGTCCATTAACCGCAGCACTTTG
CTTAAAAGGAAAAACCGAAAGCGAAATCATCTTAACGGGTGAACCTCGTATGAAAGAGCGGCCAATTCTCCATTTAGTCG
ATGCTTTACGCCAAGCGGGTGCAGATATTCGCTACTTAGAGAATGAGGGTTATCCTCCGCTCGCAATTCGCAACAAAGGG
ATAAAAGGTGGAAAAGTCAAAATTGATGGTTCAATTTCATCTCAATTTTTGACCGCACTTTTAATGTCTGCGCCACTTGC
AGAAAATGACACAGAAATAGAAATTATCGGTGAACTAGTCTCTAAACCCTATATTGACATTACCCTTGCAATGATGCGAG
ATTTTGGTGTTAAGGTTGAAAATCATCACTACCAAAAATTTCAAGTTAAGGGAAATCAATCCTATATTTCGCCTAATAAA
TACTTGGTAGAAGGCGATGCATCATCAGCCTCTTACTTTCTTGCAGCTGGCGCCATTAAAGGAAAAGTGAAAGTAACAGG
CATTGGCAAAAACTCAATTCAAGGCGATCGTTTATTTGCTGATGTATTAGAGAAAATGGGGGCAAAAATCACTTGGGGAG
AGGATTTTATCCAAGCCGAACACGCTGAATTAAATGGTATTGATATGGATATGAACCACATTCCAGATGCCGCAATGACG
ATTGCGACCACCGCACTTTTTTCCAACGGCGAAACCGTCATTCGCAATATTTATAACTGGCGAGTGAAAGAAACAGATCG
TTTAACGGCTATGGCAACTGAACTCCGTAAAGTCGGTGCAGAAGTCGAAGAAGGTGAAGATTTTATTCATATTCAACCGC
TTCCACTCAATCAATTTAAACACGCCAATATTGAGACCTATAACGATCACCGTATAGCAATGTGTTTTTCTCTAATCGCA
CTATCAAACACACCTGTGACGATTTTAGATCCCAAATGTACTGCCAAAACCTTTCCTACATTCTTTAGTGAATTTGAGAA
AATTTGCTTAAGAGATTAA

Upstream 100 bases:

>100_bases
GTGCTGGCCGTGATGTGGAAAAAACCGTGTTAAGTCGCGCCCTTGATCTCGCTTTACACGATAGAATTTTTGTTTATAAA
AATAAAACGGTGGTGTTGTA

Downstream 100 bases:

>100_bases
ATTAAAAAAGTGCGGTCAATTTCAAAAAAGTTTTCAAAATTAACCGCACTTTGTATATCAATAGAGTATTTTTACAATAT
CATACTTTTAACTTATAATT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MEKITLAPISAVEGTINLPGSKSLSNRALLLAALAKGTTKVTNLLDSDDIRHMLNALKALGVRYQLSDDKTICEVEGLGG
TFNIQDNLSLFLGNAGTAMRPLTAALCLKGKTESEIILTGEPRMKERPILHLVDALRQAGADIRYLENEGYPPLAIRNKG
IKGGKVKIDGSISSQFLTALLMSAPLAENDTEIEIIGELVSKPYIDITLAMMRDFGVKVENHHYQKFQVKGNQSYISPNK
YLVEGDASSASYFLAAGAIKGKVKVTGIGKNSIQGDRLFADVLEKMGAKITWGEDFIQAEHAELNGIDMDMNHIPDAAMT
IATTALFSNGETVIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDFIHIQPLPLNQFKHANIETYNDHRIAMCFSLIA
LSNTPVTILDPKCTAKTFPTFFSEFEKICLRD

Sequences:

>Translated_432_residues
MEKITLAPISAVEGTINLPGSKSLSNRALLLAALAKGTTKVTNLLDSDDIRHMLNALKALGVRYQLSDDKTICEVEGLGG
TFNIQDNLSLFLGNAGTAMRPLTAALCLKGKTESEIILTGEPRMKERPILHLVDALRQAGADIRYLENEGYPPLAIRNKG
IKGGKVKIDGSISSQFLTALLMSAPLAENDTEIEIIGELVSKPYIDITLAMMRDFGVKVENHHYQKFQVKGNQSYISPNK
YLVEGDASSASYFLAAGAIKGKVKVTGIGKNSIQGDRLFADVLEKMGAKITWGEDFIQAEHAELNGIDMDMNHIPDAAMT
IATTALFSNGETVIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDFIHIQPLPLNQFKHANIETYNDHRIAMCFSLIA
LSNTPVTILDPKCTAKTFPTFFSEFEKICLRD
>Mature_432_residues
MEKITLAPISAVEGTINLPGSKSLSNRALLLAALAKGTTKVTNLLDSDDIRHMLNALKALGVRYQLSDDKTICEVEGLGG
TFNIQDNLSLFLGNAGTAMRPLTAALCLKGKTESEIILTGEPRMKERPILHLVDALRQAGADIRYLENEGYPPLAIRNKG
IKGGKVKIDGSISSQFLTALLMSAPLAENDTEIEIIGELVSKPYIDITLAMMRDFGVKVENHHYQKFQVKGNQSYISPNK
YLVEGDASSASYFLAAGAIKGKVKVTGIGKNSIQGDRLFADVLEKMGAKITWGEDFIQAEHAELNGIDMDMNHIPDAAMT
IATTALFSNGETVIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDFIHIQPLPLNQFKHANIETYNDHRIAMCFSLIA
LSNTPVTILDPKCTAKTFPTFFSEFEKICLRD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=429, Percent_Identity=71.0955710955711, Blast_Score=598, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6320332, Length=443, Percent_Identity=40.6320541760722, Blast_Score=275, Evalue=9e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_HAEI8 (Q4QL19)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248938.1
- HSSP:   P0A6D3
- STRING:   Q4QL19
- GeneID:   3430711
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI1462
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   GADIEWG
- PhylomeDB:   Q4QL19
- ProtClustDB:   PRK02427
- BioCyc:   HINF281310:NTHI1462-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 47436; Mature: 47436

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKITLAPISAVEGTINLPGSKSLSNRALLLAALAKGTTKVTNLLDSDDIRHMLNALKAL
CCCEEECCHHHCCCEEECCCCCCCCCHHHEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHH
GVRYQLSDDKTICEVEGLGGTFNIQDNLSLFLGNAGTAMRPLTAALCLKGKTESEIILTG
CEEEEECCCCEEEEEECCCCEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC
EPRMKERPILHLVDALRQAGADIRYLENEGYPPLAIRNKGIKGGKVKIDGSISSQFLTAL
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCCCEEEECCCHHHHHHHHH
LMSAPLAENDTEIEIIGELVSKPYIDITLAMMRDFGVKVENHHYQKFQVKGNQSYISPNK
HHHCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHCCCEEECCCEEEEEEECCCCEECCCC
YLVEGDASSASYFLAAGAIKGKVKVTGIGKNSIQGDRLFADVLEKMGAKITWGEDFIQAE
EEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHHHHH
HAELNGIDMDMNHIPDAAMTIATTALFSNGETVIRNIYNWRVKETDRLTAMATELRKVGA
CCCCCCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCEECCCHHHHHHHHHHHHHCC
EVEEGEDFIHIQPLPLNQFKHANIETYNDHRIAMCFSLIALSNTPVTILDPKCTAKTFPT
CCCCCCCEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHH
FFSEFEKICLRD
HHHHHHHHHCCC
>Mature Secondary Structure
MEKITLAPISAVEGTINLPGSKSLSNRALLLAALAKGTTKVTNLLDSDDIRHMLNALKAL
CCCEEECCHHHCCCEEECCCCCCCCCHHHEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHH
GVRYQLSDDKTICEVEGLGGTFNIQDNLSLFLGNAGTAMRPLTAALCLKGKTESEIILTG
CEEEEECCCCEEEEEECCCCEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC
EPRMKERPILHLVDALRQAGADIRYLENEGYPPLAIRNKGIKGGKVKIDGSISSQFLTAL
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCCCEEEECCCHHHHHHHHH
LMSAPLAENDTEIEIIGELVSKPYIDITLAMMRDFGVKVENHHYQKFQVKGNQSYISPNK
HHHCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHCCCEEECCCEEEEEEECCCCEECCCC
YLVEGDASSASYFLAAGAIKGKVKVTGIGKNSIQGDRLFADVLEKMGAKITWGEDFIQAE
EEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHHHHH
HAELNGIDMDMNHIPDAAMTIATTALFSNGETVIRNIYNWRVKETDRLTAMATELRKVGA
CCCCCCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCEECCCHHHHHHHHHHHHHCC
EVEEGEDFIHIQPLPLNQFKHANIETYNDHRIAMCFSLIALSNTPVTILDPKCTAKTFPT
CCCCCCCEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHH
FFSEFEKICLRD
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA