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The map label for this gene is maeB [H]

Identifier: 148825840

GI number: 148825840

Start: 816219

End: 818489

Strand: Direct

Name: maeB [H]

Synonym: CGSHiEE_03975

Alternate gene names: 148825840

Gene position: 816219-818489 (Clockwise)

Preceding gene: 148825835

Following gene: 148825843

Centisome position: 45.02

GC content: 41.26

Gene sequence:

>2271_bases
ATGAGCGAACAATTACGTCAAGCAGCCTTAGATTTCCACGAATTTCCAATTCCTGGAAAAATCGAAGTTACCCCAACAAA
ATCACTCGCAACACAACGCGATCTTGCTTTAGCTTATTCACCAGGTGTGGCAGAGCCTTGTTTAGAAATTGAAAAAGATC
CTGCCGCCTCTTACAAATATACCGCGCGTGGCAATTTAGTAGCGGTGATTTCCAATGGTACAGCGGTACTTGGGCTTGGC
AATATTGGCGCGCTTGCCGGCAAACCCGTAATGGAAGGGAAGGGCGTATTGTTCAAAAAATTTGCAGGCATTAACGTGTT
TGATATTGAAGTGAATGAGCATGATCCCGATAAACTTGTGGATATTATTGCCTCGTTAGAGCCAACTTTCGGTGGAGTGA
ACTTAGAAGATATTAAAGCACCAGAATGTTTCTATATTGAACAAAAATTGCGTGAGAGAATGAATATTCCTGTATTCCAT
GATGACCAGCATGGCACGGCGATCATTAGTGCGGCCGCGATCATCAATTCTCTTCGTATTGTAGGTAAAAAAATTGAAGA
TGTTCGACTTGTTGCTTCTGGTGCGGGTGCAGCATCAATTGCGTGTTTGAACTTATTACTTTCTTTAGGTATGAAACGTG
AAAATATCACAGTTTGCGACTCGAAAGGCGTGGTATATAAAGGCCGTGATGACAAAATGGATCAAACCAAAAAAGATTAT
GCAATTGAAGATAATGGCTGGCGTAAACTTGGCGATGCGATTCCAAATGCAGATATTTTCTTAGGTTGTTCTGCGGCTGG
TGCGCTTACGCAAGATATGGTTAAAAGTATGGCTGCGCATCCAATTATTCTTGCTTTAGCTAATCCAAATCCTGAAATTA
CCCCGCCAGAAGCAAAAGCTGTTCGTCCTGATGCGATTGTATGTACAGGCCGTTCTGATTATCCAAACCAAGTAAATAAC
GTGCTTTGTTTCCCATTCATTTTCCGTGGTGCATTAGATGTGGGCGCAACCACTATTAATGAAGAAATGAAACGTGCGGC
AGTTTATGCCATTGCTGACCTTGCATTAGAAGAGCAAAACGAAGTGGTAACCTCTGCTTACGGTGGCGAAGGGGCAACAT
TTGGTGGGGATTATGTGATTCCTCGTCCATTTGATCCTCGCTTAATTGTGCGTATTGCACCAGCGGTAGCAAAAGCTGCA
ATGGAATCTGGTGTGGCAACTCGTCCAATTCAAAATTGGGATGCTTATGTTGAAAAACTCACTCAGTTTGTTTACAAAAC
GAGCTTGTTTATGCGTCCTATTTTCAGCCAAGCAAAATCGGCAAAACAACGCATTATTTTAGCGGAAGGGGAAGAAAATA
AAGCATTACATGCCACCCAAGAAGTGATTTCAATGGGCTTGGCAAATCCAATTTTAATTGGTCGCCGCAGCGTGATTGAA
GAAAAAATTAAAAAACTTGGTTTACGTTTAACTGCAGGTGTAGATTTTGAAATTGTGGATAACGAAGATAATCCTCGCTA
TGAAGAATGTTGGAAACACTATTACGAACTTACTAAACGTAAAGGCATTACACCTGCAATCGCAAAACGTGTCGTGCGTT
CTAACACTACCGTATTAGCTTCTACATTGCTTAGCTTAGGTTATGCAGACGCTTTAGTATGTGGTTTATTTGGTTCATAC
GGAAAACACCTTGCCTCTATTCGAGATATTATTGGCTTAAAAGACGGTGTGAAAACTGCCGCTGCTTTAAATAGTCTTGT
ATTACCGACGGGTAACGTATTCTTAACAGATACTCACGTAAACAGTAATCCTACAGCAGAAGAATTAGCTGAAATTACCT
TAATGGCAGCAGAAGAAATTCATCGTTTTGGTATTGAACCTGCAGTTGCATTGCTTTCTCATTCTAATTTTGGTTCGTCT
GATTCATTAGGCGCACCAAAAATGCGCGAAGTATTACAAATCGTCAAAGAGCACAATCCACATTTAATGATCGATGGGGA
AATGCGTGGCGATTTAGCGATGAATGAAGCACACAGAAAAGAATTAATGCCTGATAGCCCATTGAAAGGAAGCGCAAATT
TATTAGTGTTCCCTGATTTGAGTGCATCACGTATTAGTTATAGCTTATTACGCGGCACCACTACGGCAATTACCGTTGGC
CCGATCTTAATGGGTATGAATAAATCTGCGCATATTCTTAATCCAGGCGCATCTGTTCGTCGTATTATCAATATGATTGC
CTATGCAGCAGTGAAAGCACAACAAGAGTAA

Upstream 100 bases:

>100_bases
AAGTTGTAAGAATTTGCAGTTCGTCACAATTTTTTGAATAAAAAACAGATATAATCGACGCAGTATTTCAATCCTGTTTC
AAGAAAATGGAGCACTTATT

Downstream 100 bases:

>100_bases
TCGAAAAAAGTGCGGTAAATTCCCGTCGTTTATTTAATGAAGCCTCGATTTTTCTCGAGGCTTTATTTTCTAGTGAATGT
GTTTACATTTGAGATTAAGT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 755

Protein sequence:

>756_residues
MSEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLVDIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFH
DDQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKDY
AIEDNGWRKLGDAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKAVRPDAIVCTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQNEVVTSAYGGEGATFGGDYVIPRPFDPRLIVRIAPAVAKAA
MESGVATRPIQNWDAYVEKLTQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLASTLLSLGYADALVCGLFGSY
GKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHVNSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSS
DSLGAPKMREVLQIVKEHNPHLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE

Sequences:

>Translated_756_residues
MSEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLVDIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFH
DDQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKDY
AIEDNGWRKLGDAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKAVRPDAIVCTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQNEVVTSAYGGEGATFGGDYVIPRPFDPRLIVRIAPAVAKAA
MESGVATRPIQNWDAYVEKLTQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLASTLLSLGYADALVCGLFGSY
GKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHVNSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSS
DSLGAPKMREVLQIVKEHNPHLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE
>Mature_755_residues
SEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVISNGTAVLGLGN
IGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLVDIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFHD
DQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKDYA
IEDNGWRKLGDAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKAVRPDAIVCTGRSDYPNQVNNV
LCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQNEVVTSAYGGEGATFGGDYVIPRPFDPRLIVRIAPAVAKAAM
ESGVATRPIQNWDAYVEKLTQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIEE
KIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLASTLLSLGYADALVCGLFGSYG
KHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHVNSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSSD
SLGAPKMREVLQIVKEHNPHLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVGP
ILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=405, Percent_Identity=26.1728395061728, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI62420882, Length=337, Percent_Identity=26.4094955489614, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI62420880, Length=337, Percent_Identity=26.4094955489614, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI239049447, Length=337, Percent_Identity=26.4094955489614, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI4505145, Length=320, Percent_Identity=25.9375, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI270265879, Length=320, Percent_Identity=25.9375, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1788806, Length=757, Percent_Identity=68.560105680317, Blast_Score=1107, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=31.5028901734104, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI1788800, Length=324, Percent_Identity=31.4814814814815, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17537199, Length=452, Percent_Identity=23.8938053097345, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=232, Percent_Identity=31.8965517241379, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646388, Length=346, Percent_Identity=28.0346820809249, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646386, Length=348, Percent_Identity=28.448275862069, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356279, Length=489, Percent_Identity=25.5623721881391, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281362672, Length=489, Percent_Identity=25.5623721881391, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281362674, Length=489, Percent_Identity=25.5623721881391, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI78707242, Length=421, Percent_Identity=24.7030878859857, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI78707238, Length=421, Percent_Identity=24.7030878859857, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI78707240, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81806; Mature: 81675

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKY
CCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCEEEEECCCCCCHHHHCCCCCCCCEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLV
EECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
DIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISAAAIINSLRI
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
VGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKDY
HHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCHHHCCC
AIEDNGWRKLGDAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKA
EECCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VRPDAIVCTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQN
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
EVVTSAYGGEGATFGGDYVIPRPFDPRLIVRIAPAVAKAAMESGVATRPIQNWDAYVEKL
CEEEEECCCCCCCCCCCEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCEECCHHHHHH
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLA
HHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
STLLSLGYADALVCGLFGSYGKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEEECC
NSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSSDSLGAPKMREVLQIVKEHNP
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
HLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
EEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEC
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE
HHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKY
CHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCEEEEECCCCCCHHHHCCCCCCCCEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLV
EECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHHH
DIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISAAAIINSLRI
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
VGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKDY
HHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCHHHCCC
AIEDNGWRKLGDAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKA
EECCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VRPDAIVCTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQN
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
EVVTSAYGGEGATFGGDYVIPRPFDPRLIVRIAPAVAKAAMESGVATRPIQNWDAYVEKL
CEEEEECCCCCCCCCCCEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCEECCHHHHHH
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLA
HHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
STLLSLGYADALVCGLFGSYGKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEEECC
NSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSSDSLGAPKMREVLQIVKEHNP
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
HLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
EEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEC
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE
HHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]