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The map label for this gene is rnc

Identifier: 148825705

GI number: 148825705

Start: 652259

End: 652942

Strand: Direct

Name: rnc

Synonym: CGSHiEE_03240

Alternate gene names: 148825705

Gene position: 652259-652942 (Clockwise)

Preceding gene: 148825704

Following gene: 148825707

Centisome position: 35.98

GC content: 42.11

Gene sequence:

>684_bases
ATGAATCATTTAGATCGACTTGAGCGTAAAATCGGCTATTGTTTTAATGATATTGCGCTCTTAAAGCAGGCACTTACGCA
CCGAAGTGCGGCAACTCAACATAATGAACGCCTAGAATTCCTAGGCGATTCCATTCTTAATTTCACTATCGCTGAAGCAC
TTTATCATCAGTTTCCACGTTGTAATGAAGGAGAACTGAGCCGTATGCGTGCTACTTTGGTACGCGAACCCACTTTAGCG
ATTTTAGCGCGCCAATTTGAATTAGGCGATTATATGTCGCTTGGTTCTGGCGAGCTAAAGAACGGTGGTTTTCGCCGTGA
ATCTATTCTTGCCGATTGTGTAGAAGCGATTATTGGCGCAATGTCTTTGGATCAGGGATTGGCTGTGACGACCCAAGTGA
TACGAAATTGGTATCAACAGTTATTGGCAGAAATTAAACCAGGCGATAATCAAAAAGATGCGAAAACGCGTTTACAAGAA
TATTTACAAGGCAAACATTTGCCATTGCCAACTTATGAAGTGGTCAATATTCAAGGGGAAGCCCATTGCCAAATTTTCAC
TGTTGAATGCAAAGTGAAAAGTGCGGGGAAAATTGACCGCACTTTTGTGGCAAAAGGATCTAGCCGTCGTAAAGCTGAAC
AAGCGGCAGCAGAACAAATTTTAAAAGAACTGGACATCAAATGA

Upstream 100 bases:

>100_bases
GTGGGGAAAGCCACTTATATTTGGATGAGCTTAGAAAAAGAAGCGAATGAATGGCCAACAGGTTTCCGTTTTGATCGCTT
CTTTACAGCAATAAAATAAG

Downstream 100 bases:

>100_bases
CCGAACAATTCGACAAAACCTATTGCGGCTTTATTGCTATCGTAGGTCGCCCAAATGTGGGTAAATCAACGCTCTTAAAT
AAAATTTTAGGACAAAAAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MNHLDRLERKIGYCFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPRCNEGELSRMRATLVREPTLA
ILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGAMSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQE
YLQGKHLPLPTYEVVNIQGEAHCQIFTVECKVKSAGKIDRTFVAKGSSRRKAEQAAAEQILKELDIK

Sequences:

>Translated_227_residues
MNHLDRLERKIGYCFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPRCNEGELSRMRATLVREPTLA
ILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGAMSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQE
YLQGKHLPLPTYEVVNIQGEAHCQIFTVECKVKSAGKIDRTFVAKGSSRRKAEQAAAEQILKELDIK
>Mature_227_residues
MNHLDRLERKIGYCFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPRCNEGELSRMRATLVREPTLA
ILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGAMSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQE
YLQGKHLPLPTYEVVNIQGEAHCQIFTVECKVKSAGKIDRTFVAKGSSRRKAEQAAAEQILKELDIK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=29.1845493562232, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=29.1845493562232, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1788920, Length=224, Percent_Identity=64.7321428571429, Blast_Score=281, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI193202651, Length=233, Percent_Identity=32.1888412017167, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506883, Length=233, Percent_Identity=32.1888412017167, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137682, Length=235, Percent_Identity=30.6382978723404, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_HAEI8 (Q4QPN0)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_247677.1
- ProteinModelPortal:   Q4QPN0
- SMR:   Q4QPN0
- STRING:   Q4QPN0
- GeneID:   3429419
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0019
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q4QPN0
- ProtClustDB:   PRK00102
- BioCyc:   HINF281310:NTHI0019-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25604; Mature: 25604

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLDRLERKIGYCFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CNEGELSRMRATLVREPTLAILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGA
CCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQEYLQGKHLPLPTYEVVNIQGE
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCC
AHCQIFTVECKVKSAGKIDRTFVAKGSSRRKAEQAAAEQILKELDIK
CEEEEEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHLDRLERKIGYCFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CNEGELSRMRATLVREPTLAILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGA
CCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQEYLQGKHLPLPTYEVVNIQGE
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCC
AHCQIFTVECKVKSAGKIDRTFVAKGSSRRKAEQAAAEQILKELDIK
CEEEEEEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA