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The map label for this gene is thrC [H]

Identifier: 148825636

GI number: 148825636

Start: 574454

End: 575731

Strand: Direct

Name: thrC [H]

Synonym: CGSHiEE_02850

Alternate gene names: 148825636

Gene position: 574454-575731 (Clockwise)

Preceding gene: 148825635

Following gene: 148825637

Centisome position: 31.68

GC content: 39.2

Gene sequence:

>1278_bases
ATGAATTTATACAATATCAAACACCCAGAAGAACAAGTCACTTTTTCTCAGGCTGTTCGTCAAGGTCTTGGGCGGGATCA
AGGTTTATTCTTTCCAGAAGTTATTCCTAAACTTAATAACATTAATGAATTACTTGAATTGCCTCTTGTTGAGCGTAGCC
AAAAAATTCTAGGTGCATTAATTGGTGAAGAATTACCGAAAGCAACGTTAGACGAGATGGTGAGAAATGCATTCACTTTC
ACCGCACCGTTAGAAAAAGTTGAAGATAATATTTATGCACTTGAATTATTTCATGGTCCCACATTGGCATTTAAAGACTT
TGGTGGTCGTTTTATGGCACAGGCACTTGCTGCGGTACGTGGTGATGGAAAAACCACCATTTTAACGGCTACGTCTGGCG
ATACTGGAGCTGCTGTAGCACATGCGTTTTATGGATTAAAAAATATTAATGTAGTTATCCTTTATCCAAAAGGTAAAATC
AGCCCATTACAAGAAAAGCTATTCTGTACTTTAGGTAGGAATATTCGTACTGTTGCGATTAACGCTGATTTCGATGCGTG
CCAGGCTTTAGTTAAGCAAGCCTTTGATGATGTTGAATTGCGCCAAGCTATCGGGCTTAACTCTGCAAATTCTATTAATA
TCAGCCGTTTATTAGCTCAAGTTTGTTATTACTTTGAGGCTGTCGCACAATTGCCAAAAGAAAAACGTGATAATGTCGTG
GTTTCTGTGCCAAGCGGTAATTTTGGTAACTTAACGGCGGGATTAATTGCAAAAACCTTAGGCTTGCCGATAAAACGCTT
TGTCGCCTCAACAAACGCAAATGATACTGTGCCACGTTATTTGAAATCGGGTAATTGGGATCCTAAAACGACAGTTGCAA
CCCTTTCTAATGCAATGGATGTAAGTCGCCCAAATAATTGGCCGAGAGTGGAGGAATTGTTTAAACGAAATGGTTGGGAT
TTAACTGATTTAGGTTCGGGGATGCTAAGTGATAGCGAAACAGAAGATACTTTAAAAGCGATGCAGTCGAAAGGTTATTT
ATGTGAGCCTCACGGTGCGATAGCTTATCAGGTGTTGAAAGATCAACTTAAAGCAGATGAAGTAGGCATTTTCTTGTGCA
CTGCACATCCAGCGAAATTTAAAGAATCCGTAGAACGTATTCTTGGTATTCAGCTTCCATTACCTGAAACACTGGATAAA
CATAATCAGCTACCATTGCTTTCTGATGAAATGGATAATGATTTTGCACAACTACGGGCTTACTTATTGAAGTCATAA

Upstream 100 bases:

>100_bases
TGAAGGTTTTGTGCATGTATGTAAAGTTGATAACGAAGGCACAAGAGAAATTAAATAAGTTAATTTAAATAGATGAAATC
AGATTAAAAACGGATTAAAT

Downstream 100 bases:

>100_bases
AGTGCGGTAAATTTTTATTGTGTTTTGGATAGCATCTGATTTTCAGGTGCTATTTTATTTTAGAAAATATAACGTAGCGA
TAAAATATATTAATTATTTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPKLNNINELLELPLVERSQKILGALIGEELPKATLDEMVRNAFTF
TAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKTTILTATSGDTGAAVAHAFYGLKNINVVILYPKGKI
SPLQEKLFCTLGRNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLKDQLKADEVGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS

Sequences:

>Translated_425_residues
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPKLNNINELLELPLVERSQKILGALIGEELPKATLDEMVRNAFTF
TAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKTTILTATSGDTGAAVAHAFYGLKNINVVILYPKGKI
SPLQEKLFCTLGRNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLKDQLKADEVGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS
>Mature_425_residues
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPKLNNINELLELPLVERSQKILGALIGEELPKATLDEMVRNAFTF
TAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKTTILTATSGDTGAAVAHAFYGLKNINVVILYPKGKI
SPLQEKLFCTLGRNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLKDQLKADEVGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=460, Percent_Identity=31.0869565217391, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI149193323, Length=428, Percent_Identity=29.9065420560748, Blast_Score=162, Evalue=5e-40,
Organism=Escherichia coli, GI1786185, Length=425, Percent_Identity=66.5882352941177, Blast_Score=573, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319901, Length=447, Percent_Identity=34.4519015659955, Blast_Score=221, Evalue=1e-58,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46885; Mature: 46885

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPKLNNINELLELPLVERSQKILGAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHH
IGEELPKATLDEMVRNAFTFTAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVR
HHHHCCHHHHHHHHHHHEEHHCCHHHHCCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHH
GDGKTTILTATSGDTGAAVAHAFYGLKNINVVILYPKGKISPLQEKLFCTLGRNIRTVAI
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
NADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCEE
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWDLTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLK
CCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHH
DQLKADEVGIFLCTAHPAKFKESVERILGIQLPLPETLDKHNQLPLLSDEMDNDFAQLRA
HHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
YLLKS
HHHCC
>Mature Secondary Structure
MNLYNIKHPEEQVTFSQAVRQGLGRDQGLFFPEVIPKLNNINELLELPLVERSQKILGAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHH
IGEELPKATLDEMVRNAFTFTAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVR
HHHHCCHHHHHHHHHHHEEHHCCHHHHCCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHH
GDGKTTILTATSGDTGAAVAHAFYGLKNINVVILYPKGKISPLQEKLFCTLGRNIRTVAI
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
NADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCEE
VSVPSGNFGNLTAGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWDLTDLGSGMLSDSETEDTLKAMQSKGYLCEPHGAIAYQVLK
CCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCEECCCCHHHHHHHH
DQLKADEVGIFLCTAHPAKFKESVERILGIQLPLPETLDKHNQLPLLSDEMDNDFAQLRA
HHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
YLLKS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]