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The map label for this gene is dxs [H]

Identifier: 148824588

GI number: 148824588

Start: 3805732

End: 3807342

Strand: Reverse

Name: dxs [H]

Synonym: TBFG_13415

Alternate gene names: 148824588

Gene position: 3807342-3805732 (Counterclockwise)

Preceding gene: 148824589

Following gene: 148824587

Centisome position: 86.05

GC content: 64.18

Gene sequence:

>1611_bases
GTGTTCGACACCGGGCACCAAACCTATCCGCACAAGCTGCTCACCGGCCGCGGTAAAGACTTCGCCACGCTGCGCCAGGC
CGATGGTCTATCGGGGTATCCCAACCGCCATGAATCGCCACATGACTGGGTCGAGAACTCCCATGCCTCGGTCAGCCTCG
CCTGGGTGGACGGCATCGCCAAAGCATTGGCCCTGCAGGGGCAATGCGACCGACGTGTCATCGCGGTGATCGGTGATGGC
GCCCTCACCGGGGGCGTGGCATGGGAGGGCCTGAACAACCTCGGTGCCGCTACCCGGCCCGTGATCGTCGTGCTCAATGA
CAATGGCCGCTCCTACGACCCCACCGCTGGGGCTCTTGCGGCACACCTAGAAGAACTTCGCGTCGGCACACCCCGAGGGC
CGAACCTCTTTGAGAACATGGGATTTACCTACATCGGTCCGGTCGATGGGCACAACATCCCCGACACGTGCGCGGTTCTA
CGAAAAGCGGCCGCGGCAGCTAGGCCCGTTGTTGTTCACGCAGTGACTAGTAAGGGCCGGGGTTATCCTCCAGCCGAAGC
TGACGAGAGGGACCATATGCACGCCTGCGGGGTGGTCGACATTGCCACCGGCCTCGCTAGCACACCCAGTCAGCGGAGCT
GGACCGACGTGTTCGAGGACGAAATCGCGCGCATTGCTGACGACCGATCCGACGTCGTCGGGCTGACCGCGGCGATGCGT
CTGCCCACTGGTCTAGGCGCGCTGTCGAGGCGATACCCGCATCGGGTGTTCGATTCGGGCATCGCCGAACAACACCTGTT
GGCCAGCGCGGCCGGGCTAGCTGCCGCGGGAACCCATCCCGTTGTCGCGGTGTACTCGACGTTTCTGCACCGCGCCTTTG
ACCAACTTCTGTTCGACATCGGGCTGCACCGGTTACCCGTGACGCTGGTGCTGGACCGGGCTGGGGTAACCGGGCCCGAC
GGACCCAGCCATCACGGTTTGTGGGATCTGGCGCTGCTGGCCTGCGTGCCCGGGTTTCAGATCGCCTGTCCGCGCGACGC
GCCTCGGCTACGACAACAGTTGCGTACCGCGATCGCGACCGCGGCTCCCACCGCCGTGCGTTTCCCCAAAGGGGCGCCGG
GCGAACCGATCACGGCCGAACACACCATCGGTGGCCTCGACGTCTTGCATACACCACCACCGCATTGGCGACCCGACGTG
CTCTTGGTCGCAGTGGGTGCCATGAGTCGACCATGCATGGACGCCGCCCGGTGCCTCAGCGAGGAGCAGATCGGGGTGAC
AGTCGTTGATCCACAATGGGTCTGGCCAATCAGCCCGGCACTGACCGAGCTGGCTGGCCGCCATCGGATCACCGTGTGTG
TCGAAGATGCGATTGCCGACGTGGGAATCGGCGCGCACCTTAGCCACCACATCGGGCGGACACACCCGCGGACGCGCACC
TACACACTGGGACTGCCACCGGCCTACATTCCCCACGCCAGCCGCGACCACATCCTTTCCAGCCACGGACTCACCGGCCC
CGCAATCCGCATAAGATGCAAATCACTACTTAACGCACTACATGAAGTCCCTGGACCCGAAGACCATCCTGATTCCGGCG
ATAGTTATTAA

Upstream 100 bases:

>100_bases
GAAACAGTGACGGCTACCGGTGGCCATCTCGGCGCGGGACTTGGCATGGTAGAGCTGACCATCGCATTGCATCGGGTGTT
CACCTCGCCACACGACATCG

Downstream 100 bases:

>100_bases
GAGGAAGCATGAACTTGGTTAGCGAAAAAGAATTCTTGGATCTTCCTCTAGTATCCGTAGCAGAGATTGTACGTTGCCGT
GGACCGAAGGTATCCGTCTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDG
ALTGGVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVL
RKAAAAARPVVVHAVTSKGRGYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMR
LPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPD
GPSHHGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDV
LLVAVGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRT
YTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY

Sequences:

>Translated_536_residues
MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDG
ALTGGVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVL
RKAAAAARPVVVHAVTSKGRGYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMR
LPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPD
GPSHHGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDV
LLVAVGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRT
YTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY
>Mature_536_residues
MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDG
ALTGGVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVL
RKAAAAARPVVVHAVTSKGRGYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMR
LPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPD
GPSHHGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDV
LLVAVGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRT
YTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=452, Percent_Identity=24.5575221238938, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4507521, Length=452, Percent_Identity=24.5575221238938, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI133778974, Length=484, Percent_Identity=24.3801652892562, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786622, Length=556, Percent_Identity=34.7122302158273, Blast_Score=300, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17539652, Length=489, Percent_Identity=24.1308793456033, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45551847, Length=446, Percent_Identity=26.9058295964126, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550715, Length=446, Percent_Identity=26.9058295964126, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24645119, Length=446, Percent_Identity=26.9058295964126, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24666278, Length=494, Percent_Identity=25.1012145748988, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 57181; Mature: 57181

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIA
CCCCCCCCCCCHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHHH
KALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALA
HHHHHCCCCCCEEEEEEECCCCCCCHHHHCHHHCCCCCCCEEEEECCCCCCCCCCHHHHH
AHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAAAAARPVVVHAVTSKGR
HHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCC
GYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMR
CCCCCCCCCCCCHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDI
CCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
GLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIAT
CHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHH
AAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVAVGAMSRPCMDAARCLS
CCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHCC
EEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRT
CCCCCEEEECCCEECCCCHHHHHHCCCCEEEEEEHHHHHHCCCCHHHHHHHCCCCCCCEE
YTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY
EEECCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIA
CCCCCCCCCCCHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHHH
KALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALA
HHHHHCCCCCCEEEEEEECCCCCCCHHHHCHHHCCCCCCCEEEEECCCCCCCCCCHHHHH
AHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAAAAARPVVVHAVTSKGR
HHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCC
GYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMR
CCCCCCCCCCCCHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDI
CCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
GLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIAT
CHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHH
AAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVAVGAMSRPCMDAARCLS
CCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHCC
EEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRT
CCCCCEEEECCCEECCCCHHHHHHCCCCEEEEEEHHHHHHCCCCHHHHHHHCCCCCCCEE
YTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY
EEECCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA