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The map label for this gene is adhC

Identifier: 148824236

GI number: 148824236

Start: 3417995

End: 3419035

Strand: Direct

Name: adhC

Synonym: TBFG_13061

Alternate gene names: 148824236

Gene position: 3417995-3419035 (Clockwise)

Preceding gene: 148824235

Following gene: 148824247

Centisome position: 77.25

GC content: 64.65

Gene sequence:

>1041_bases
ATGAGCACTGTTGCCGCCTACGCCGCCATGTCGGCGACCGAACCCCTGACCAAGACCACGATCACCCGTCGCGACCCGGG
CCCGCACGACGTGGCGATCGACATCAAGTTCGCCGGAATCTGTCACTCGGACATCCATACCGTCAAAGCCGAGTGGGGCC
AACCGAATTACCCTGTGGTCCCTGGCCACGAGATCGCCGGCGTGGTGACCGCCGTGGGCTCGGAGGTGACCAAGTACCGG
CAGGGCGACCGCGTTGGGGTTGGCTGTTTCGTGGACTCGTGCCGCGAGTGCAACAGTTGCACGCGCGGCATCGAACAGTA
CTGCAAGCCGGGCGCAAACTTCACCTACAACTCGATCGGCAAAGACGGCCAGCCAACCCAGGGCGGCTACAGCGAAGCGA
TCGTCGTCGACGAAAACTACGTGTTGCGCATACCCGACGTGCTGCCCCTGGATGTGGCGGCGCCGCTGTTGTGCGCGGGC
ATCACGCTGTACTCGCCACTGCGCCACTGGAATGCCGGGGCGAACACGCGGGTGGCGATCATCGGCCTAGGCGGACTGGG
TCACATGGGCGTCAAGCTGGGCGCCGCGATGGGCGCCGACGTGACGGTGCTGTCCCAATCGCTGAAGAAAATGGAGGACG
GTCTGCGCTTGGGGGCCAAGAGCTACTACGCGACCGCCGACCCGGACACCTTCCGCAAGCTGCGCGGCGGCTTCGACCTG
ATCCTGAACACCGTCTCGGCTAACTTGGACCTCGGCCAGTACCTGAACCTGCTGGACGTCGACGGCACACTCGTGGAACT
GGGTATCCCCGAGCACCCCATGGCCGTGCCGGCGTTCGCGCTAGCGCTCATGCGACGCAGCCTGGCCGGGTCCAACATCG
GCGGGATCGCCGAGACCCAGGAGATGCTCAATTTCTGTGCCGAGCACGGCGTGACACCCGAAATCGAGCTGATTGAACCG
GACTACATCAACGACGCCTACGAGCGCGTGCTGGCCAGCGACGTGCGCTACCGCTTCGTCATCGACATCTCAGCCCTGTG
A

Upstream 100 bases:

>100_bases
TCTGCGCTGGGTCGACGCGCCGATCAACTAGTGAGGCGCAGCGCTAGGCTTTGGGATACCCACAGCTAAAAAGTTAATCA
AAGAAACGAAGAGGGTTGCC

Downstream 100 bases:

>100_bases
GGCCGGTGCGCGATCACTTCCGGATTCGGACTCGCCGACGTCGACGCCGGCCAGCGGCCATCCGGCGGCGGCCAGGATGC
CTGCCACCCGTTGGATGTTT

Product: NADP-dependent alcohol dehydrogenase adhC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYR
QGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAG
ITLYSPLRHWNAGANTRVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRKLRGGFDL
ILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEP
DYINDAYERVLASDVRYRFVIDISAL

Sequences:

>Translated_346_residues
MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYR
QGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAG
ITLYSPLRHWNAGANTRVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRKLRGGFDL
ILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEP
DYINDAYERVLASDVRYRFVIDISAL
>Mature_345_residues
STVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYRQ
GDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAGI
TLYSPLRHWNAGANTRVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRKLRGGFDLI
LNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPD
YINDAYERVLASDVRYRFVIDISAL

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4501933, Length=330, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI34577061, Length=330, Percent_Identity=26.0606060606061, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI262073058, Length=230, Percent_Identity=26.9565217391304, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI71743840, Length=230, Percent_Identity=26.9565217391304, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4501929, Length=316, Percent_Identity=26.2658227848101, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71565154, Length=216, Percent_Identity=30.0925925925926, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71565152, Length=212, Percent_Identity=25.9433962264151, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4501939, Length=348, Percent_Identity=25.2873563218391, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI156523966, Length=348, Percent_Identity=25.2873563218391, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=52.4495677233429, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI87082401, Length=346, Percent_Identity=37.2832369942197, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI87081918, Length=332, Percent_Identity=25.6024096385542, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082125, Length=257, Percent_Identity=28.0155642023346, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790045, Length=283, Percent_Identity=27.5618374558304, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788075, Length=283, Percent_Identity=25.0883392226148, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788073, Length=267, Percent_Identity=25.8426966292135, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=29.4642857142857, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787863, Length=137, Percent_Identity=33.5766423357664, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI226510992, Length=260, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=26.4094955489614, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=28.2352941176471, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=26.4957264957265, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=230, Percent_Identity=29.1304347826087, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=204, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=183, Percent_Identity=28.4153005464481, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=232, Percent_Identity=28.448275862069, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=342, Percent_Identity=36.5497076023392, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319949, Length=326, Percent_Identity=35.8895705521472, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323961, Length=327, Percent_Identity=30.2752293577982, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=29.3577981651376, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=27.7286135693215, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=27.4390243902439, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319257, Length=302, Percent_Identity=27.4834437086093, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=234, Percent_Identity=29.0598290598291, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=308, Percent_Identity=25.3246753246753, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=296, Percent_Identity=24.3243243243243, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=296, Percent_Identity=24.3243243243243, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17737895, Length=206, Percent_Identity=30.5825242718447, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADHC_MYCBO (P0A4X1)

Other databases:

- EMBL:   X63450
- EMBL:   BX248344
- PIR:   JC1376
- RefSeq:   NP_856716.1
- ProteinModelPortal:   P0A4X1
- SMR:   P0A4X1
- EnsemblBacteria:   EBMYCT00000015733
- GeneID:   1092114
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3071
- GeneTree:   EBGT00050000015148
- HOGENOM:   HBG753318
- OMA:   TPFTFER
- ProtClustDB:   CLSK792243
- BioCyc:   MBOV233413:MB3071-MONOMER
- BRENDA:   1.1.1.2
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.2

Molecular weight: Translated: 37076; Mature: 36944

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSDIHTVKAEWGQPNYPVV
CCCHHHHHHHHCCCCCHHHEEECCCCCCCCEEEEEEEECEECCCHHHHHHCCCCCCCCCC
PGHEIAGVVTAVGSEVTKYRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIG
CCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCC
KDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANTRVAI
CCCCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
IGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRKLRGGFDL
EEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCHHH
ILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQ
HHHHHHCCCCHHHHHCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
EMLNFCAEHGVTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL
HHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCEEEEEEEEECC
>Mature Secondary Structure 
STVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSDIHTVKAEWGQPNYPVV
CCHHHHHHHHCCCCCHHHEEECCCCCCCCEEEEEEEECEECCCHHHHHHCCCCCCCCCC
PGHEIAGVVTAVGSEVTKYRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIG
CCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCC
KDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANTRVAI
CCCCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
IGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRKLRGGFDL
EEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCHHH
ILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQ
HHHHHHCCCCHHHHHCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
EMLNFCAEHGVTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL
HHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1427101; 12788972