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The map label for this gene is 148824138

Identifier: 148824138

GI number: 148824138

Start: 3311444

End: 3312043

Strand: Reverse

Name: 148824138

Synonym: TBFG_12963

Alternate gene names: NA

Gene position: 3312043-3311444 (Counterclockwise)

Preceding gene: 148824139

Following gene: 148824137

Centisome position: 74.86

GC content: 52.5

Gene sequence:

>600_bases
ATGACCGAGTGTTTTCTATCTGATCAAGAGATCCGAAAGCTCAATCGTGACCTTCGAATACTGATAGCAGCTAATGGCAC
CCTCACTAGGGTTCTCAACATTGTCGCTGACGATGAGGTGATCGTGCAAATCGTCAAGCAGCGGATTCACGATGTTTCAC
CGAAGCTATCCGAATTCGAGCAGCTAGGGCAGGTGGGGGTCGGCCGTGTTCTGCAGCGGTACATCATACTTAAAGGTCGG
AACTCGGAACACTTATTTGTAGCCGCGGAGTCGTTGATTGCGATTGATCGGTTGCCGGCTGCAATTATAACAAGGTTGAC
GCAGACAAACGATCCTCTCGGCGAGGTTATGGCAGCCAGCCACATCGAGACCTTCAAGGAAGAGGCTAAAGTCTGGGTCG
GAGATTTGCCAGGTTGGCTCGCGCTCCACGGGTATCAGAATTCCCGAAAGAGAGCCGTTGCCCGCCGTTATCGCGTTATT
TCCGGAGGCCAGCCGATCATGGTGGTGACGGAGCACTTTCTACGAAGCGTATTTCGAGATGCTCCGCATGAAGAACCTGA
TCGCTGGCAGTTTTCAAATGCCATCACTCTGGCGCGCTAG

Upstream 100 bases:

>100_bases
GGTAAGGTTCGGCGTTCGGCCAGCGTTGAGCGTTACCTACATCACGAATTCAGCCGCCTAGATGCTATGGCATAACAGCG
CATGTATGTGGGGGAAGAAT

Downstream 100 bases:

>100_bases
GGCGGTCATCCAATAAATGCGGAATGGGAATCTAGCGGGGCTCCTGGCTGAGCAGGCATCGGAGGCGGGATGGTACGACC
GGCCGGCCTTCTATGCGGCC

Product: hypothetical protein

Products: NA

Alternate protein names: 4-HB synthase; p-hydroxybenzoic acid synthase

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIHDVSPKLSEFEQLGQVGVGRVLQRYIILKGR
NSEHLFVAAESLIAIDRLPAAIITRLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVI
SGGQPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR

Sequences:

>Translated_199_residues
MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIHDVSPKLSEFEQLGQVGVGRVLQRYIILKGR
NSEHLFVAAESLIAIDRLPAAIITRLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVI
SGGQPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR
>Mature_198_residues
TECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIHDVSPKLSEFEQLGQVGVGRVLQRYIILKGRN
SEHLFVAAESLIAIDRLPAAIITRLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVIS
GGQPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR

Specific function: Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p-hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobact

COG id: COG3161

COG function: function code H; 4-hydroxybenzoate synthetase (chorismate lyase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate--pyruvate lyase type 2 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHBS_MYCBO (Q7TXK6)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856618.1
- ProteinModelPortal:   Q7TXK6
- SMR:   Q7TXK6
- EnsemblBacteria:   EBMYCT00000014359
- GeneID:   1092132
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2973c
- GeneTree:   EBGT00050000018489
- HOGENOM:   HBG569014
- OMA:   LETHRPI
- ProtClustDB:   CLSK792184
- BioCyc:   MBOV233413:MB2973C-MONOMER
- InterPro:   IPR002800

Pfam domain/function: PF01947 DUF98

EC number: NA

Molecular weight: Translated: 22587; Mature: 22456

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIHDVSPKLSEFE
CCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHH
QLGQVGVGRVLQRYIILKGRNSEHLFVAAESLIAIDRLPAAIITRLTQTNDPLGEVMAAS
HHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
HIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVISGGQPIMVVTEHFLRSVFRD
HHHHHHHHHHEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
APHEEPDRWQFSNAITLAR
CCCCCCCCEECCCEEEECC
>Mature Secondary Structure 
TECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIHDVSPKLSEFE
CCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHH
QLGQVGVGRVLQRYIILKGRNSEHLFVAAESLIAIDRLPAAIITRLTQTNDPLGEVMAAS
HHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
HIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVISGGQPIMVVTEHFLRSVFRD
HHHHHHHHHHEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
APHEEPDRWQFSNAITLAR
CCCCCCCCEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972