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The map label for this gene is 148824101

Identifier: 148824101

GI number: 148824101

Start: 3230803

End: 3231390

Strand: Reverse

Name: 148824101

Synonym: TBFG_12926

Alternate gene names: NA

Gene position: 3231390-3230803 (Counterclockwise)

Preceding gene: 148824102

Following gene: 148824099

Centisome position: 73.04

GC content: 64.46

Gene sequence:

>588_bases
ATGGCCAGGACCCAGCAGCAGCGCCGCGAAGAAACCGTTGCACGGCTTCTGCAGGCCAGCATCGACACGATCATCGAGGT
CGGCTACGCGCGGGCATCGGCTGCCGTGATCACCAAGCGGGCTGGGGTGTCGGTAGGCGCCCTGTTCCGGCACTTCGAAA
CGATGGGTGATTTCATGGCGGCCACGGCATACGAGGTGTTGCGCCGTCAGCTGGAAACGTTCACCAAGCAAGTCGCCGAA
ATACCGGCCGATCGGCCGGCGCTTCCGGCGGCGCTGACGATTTTGCGGGACATCACGGCCGGCTCCACGAATGCGGTGCT
CTACGAGCTTATGGTCGCCGCGCGCACCGACGAGAAGCTCAAGGAGACGCTGCAGAATGTGCTGGGGCAGTACAGCGCGA
AGATCCACGACGCCGCGCGTGCTCTGCCGGGTGCCGAGAGCTTTCCGGAGGAGACATTTCCGGTCATCGTGGCGTTGATG
ACCAACGTCTTCGACGGCGCCGCCATTGTGCGAGGGGTACTGCCGCAGCCCGAACTCGAGGAACAGCGGATTCCCATGCT
GACGGCGCTGCTGACCGCCGGCCTATGA

Upstream 100 bases:

>100_bases
TTCGGAGGTCAGTTCCGCGACGGCTACGGGCAGAACGTGAAGTCGGGTCGCTACCTGCGGGCGGGTGAGCTCGGCGCCGC
TCTGAGCCGTTCTGCCTGAC

Downstream 100 bases:

>100_bases
GCGCCAGCAGACGCAAAAGAACATGATGGGCGCACCAGCGCCCACGTCTGCTCGCGGTGCTAGAGCGAGCCGACGCTGGC
CTGCGGGTTGAGGGCGAAAC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MARTQQQRREETVARLLQASIDTIIEVGYARASAAVITKRAGVSVGALFRHFETMGDFMAATAYEVLRRQLETFTKQVAE
IPADRPALPAALTILRDITAGSTNAVLYELMVAARTDEKLKETLQNVLGQYSAKIHDAARALPGAESFPEETFPVIVALM
TNVFDGAAIVRGVLPQPELEEQRIPMLTALLTAGL

Sequences:

>Translated_195_residues
MARTQQQRREETVARLLQASIDTIIEVGYARASAAVITKRAGVSVGALFRHFETMGDFMAATAYEVLRRQLETFTKQVAE
IPADRPALPAALTILRDITAGSTNAVLYELMVAARTDEKLKETLQNVLGQYSAKIHDAARALPGAESFPEETFPVIVALM
TNVFDGAAIVRGVLPQPELEEQRIPMLTALLTAGL
>Mature_194_residues
ARTQQQRREETVARLLQASIDTIIEVGYARASAAVITKRAGVSVGALFRHFETMGDFMAATAYEVLRRQLETFTKQVAEI
PADRPALPAALTILRDITAGSTNAVLYELMVAARTDEKLKETLQNVLGQYSAKIHDAARALPGAESFPEETFPVIVALMT
NVFDGAAIVRGVLPQPELEEQRIPMLTALLTAGL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2912_MYCTU (P67440)

Other databases:

- EMBL:   BX842581
- EMBL:   AE000516
- PIR:   C70928
- RefSeq:   NP_217428.1
- RefSeq:   NP_337492.1
- ProteinModelPortal:   P67440
- EnsemblBacteria:   EBMYCT00000002799
- EnsemblBacteria:   EBMYCT00000071180
- GeneID:   888017
- GeneID:   925296
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2980
- KEGG:   mtu:Rv2912c
- TIGR:   MT2980
- TubercuList:   Rv2912c
- GeneTree:   EBGT00050000014711
- HOGENOM:   HBG567537
- OMA:   YELMIAA
- ProtClustDB:   CLSK792155
- GO:   GO:0005829
- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647
- Gene3D:   G3DSA:1.10.357.10
- PRINTS:   PR00455

Pfam domain/function: PF00440 TetR_N; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 21239; Mature: 21108

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01081 HTH_TETR_1; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTQQQRREETVARLLQASIDTIIEVGYARASAAVITKRAGVSVGALFRHFETMGDFMA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ATAYEVLRRQLETFTKQVAEIPADRPALPAALTILRDITAGSTNAVLYELMVAARTDEKL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
KETLQNVLGQYSAKIHDAARALPGAESFPEETFPVIVALMTNVFDGAAIVRGVLPQPELE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EQRIPMLTALLTAGL
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARTQQQRREETVARLLQASIDTIIEVGYARASAAVITKRAGVSVGALFRHFETMGDFMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ATAYEVLRRQLETFTKQVAEIPADRPALPAALTILRDITAGSTNAVLYELMVAARTDEKL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
KETLQNVLGQYSAKIHDAARALPGAESFPEETFPVIVALMTNVFDGAAIVRGVLPQPELE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EQRIPMLTALLTAGL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036