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The map label for this gene is 148823650

Identifier: 148823650

GI number: 148823650

Start: 2764987

End: 2766246

Strand: Reverse

Name: 148823650

Synonym: TBFG_12475

Alternate gene names: NA

Gene position: 2766246-2764987 (Counterclockwise)

Preceding gene: 148823651

Following gene: 148823649

Centisome position: 62.52

GC content: 68.41

Gene sequence:

>1260_bases
GTGACCGCTACGCCGCGTGAATTCGACATCGTGTTGTACGGGGCGACCGGCTTCGTCGGCAAGCTGACCGCCGAATACCT
GGCCCGGGCCGGGGGAGATGCCCGGATCGCGCTGGCCGGCAGGTCGACGCAACGGGTGCTCGCCGTTCGCGAAGCCCTGG
GCGAATCCGCGCAGACCTGGCCGATCCTGACCGCCGACGCGTCGTTGCCGTCGACGCTGCAAGCCATGGCCGCCCGCGCC
CAGGTCGTGGTCACCACCGTTGGGCCCTACACCCGCTACGGGCTGCCGCTGGTGGCCGCATGCGCTGCCGCCGGCACCGA
CTACGCCGACCTGACCGGCGAGCCGATGTTCATGCGCAACAGCATCGACTTGTACCACAAGCAGGCCGCCGACACCGGTG
CACGCATCGTGCACGCCTGCGGATTCGACTCCGTCCCATCTGATCTGAGCGTGTACGCCCTATACCACGCGGCACGAGAA
GACGGCGCCGGCGAGCTGACCGACACCAACTGCGTGGTGCGTTCCTTCAAAGGCGGGTTCTCCGGCGGCACCATCGCATC
GATGCTGGAGGTGTTGAGCACCGCTTCTAACGATCCCGATGCGCGCCGCCAGCTATCCGACCCCTACATGCTGAGCCCAG
ACCGCGGCGCCGAACCCGAACTGGGCCCACAGCCTGACCTGCCGTCGCGTCGTGGCCGTCGGCTCGCGCCGGAACTGGCC
GGTGTGTGGACCGCGGGATTCATCATGGCGCCCACCAACACCCGGATCGTGCGCCGCAGCAACGCGCTCCTGGACTGGGC
CTACGGCCGGCGGTTCCGCTACAGCGAAACCATGAGCGTAGGGTCCACGGTGCTGGCGCCGGTGGTATCGGTTGTCGGCG
GCGGTGTCGGCAACGCGATGTTCGGCTTGGCCAGCCGCTACATCCGCCTGCTGCCGCGGGGACTGGTAAAGCGTGTCGTC
CCCAAACCCGGCACCGGCCCCAGTGCGGCGGCTCGCGAGCGCGGCTACTACCGCATCGAGACCTACACCACCACAACCAC
CGGAGCCCGGTACCTGGCGCGCATGGCCCAAGATGGTGACCCCGGCTACAAGGCGACGTCGGTGTTGTTGGGGGAGTGTG
GTCTGGCGCTGGCACTGGATCGCGACAAGCTGTCCGACATGCGTGGTGTGTTAACCCCCGCGGCCGCAATGGGTGACGCC
CTGCTGGAGCGTTTGCCGGCCGCCGGTGTGTCGCTGCAGACCACGCGACTGGCTAGCTGA

Upstream 100 bases:

>100_bases
GCCGCGGCTGACCACCGCGAAAAGACGCAAAAGCTCCCAAATCCGGTCGGATTTGGGAGCTTTTGCGTCTGCTCGCGCAC
CCCGGAGTAGCGTCAAACCC

Downstream 100 bases:

>100_bases
ATCCGGGCGGTTTCGGGCGCTTTCATGCCGGTGTGAAGCGGTTCCTAGAATTGATCGGTGACCGCCAGCCCTCACCCTGC
CGCCGATATGCTGCCCAAGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTWPILTADASLPSTLQAMAARA
QVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAARE
DGAGELTDTNCVVRSFKGGFSGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELA
GVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAMFGLASRYIRLLPRGLVKRVV
PKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDA
LLERLPAAGVSLQTTRLAS

Sequences:

>Translated_419_residues
MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTWPILTADASLPSTLQAMAARA
QVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAARE
DGAGELTDTNCVVRSFKGGFSGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELA
GVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAMFGLASRYIRLLPRGLVKRVV
PKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDA
LLERLPAAGVSLQTTRLAS
>Mature_418_residues
TATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTWPILTADASLPSTLQAMAARAQ
VVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAARED
GAGELTDTNCVVRSFKGGFSGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELAG
VWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAMFGLASRYIRLLPRGLVKRVVP
KPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDAL
LERLPAAGVSLQTTRLAS

Specific function: Unknown

COG id: COG3268

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily

Homologues:

Organism=Homo sapiens, GI55770836, Length=456, Percent_Identity=27.4122807017544, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI32567112, Length=201, Percent_Identity=32.8358208955224, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17560066, Length=201, Percent_Identity=32.8358208955224, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71991033, Length=154, Percent_Identity=34.4155844155844, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646278, Length=438, Percent_Identity=27.1689497716895, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24644140, Length=429, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24644142, Length=429, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21356081, Length=429, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2449_MYCTU (O53176)

Other databases:

- EMBL:   BX842579
- PIR:   H70863
- RefSeq:   NP_216965.1
- ProteinModelPortal:   O53176
- EnsemblBacteria:   EBMYCT00000000537
- GeneID:   885894
- GenomeReviews:   AL123456_GR
- KEGG:   mtu:Rv2449c
- TubercuList:   Rv2449c
- GeneTree:   EBGT00050000017653
- HOGENOM:   HBG527018
- OMA:   GYGSTSK
- ProtClustDB:   CLSK872065
- GO:   GO:0005488
- InterPro:   IPR016040
- InterPro:   IPR005097
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF03435 Saccharop_dh

EC number: NA

Molecular weight: Translated: 44379; Mature: 44248

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1bfec20c)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTW
CCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCC
PILTADASLPSTLQAMAARAQVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRN
EEEEECCCCHHHHHHHHHCCEEEEEECCCHHHHCHHHHHHHHHCCCCHHHCCCCCEEEEC
SIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAAREDGAGELTDTNCVVRSFKGGF
CHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
SGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELA
CCCHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHH
GVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAM
HHHHCCEEECCCCCEEEECCCCEEEHHCCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHH
FGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCC
PGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDALLERLPAAGVSLQTTRLAS
CCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCH
>Mature Secondary Structure 
TATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTW
CCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCC
PILTADASLPSTLQAMAARAQVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRN
EEEEECCCCHHHHHHHHHCCEEEEEECCCHHHHCHHHHHHHHHCCCCHHHCCCCCEEEEC
SIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAAREDGAGELTDTNCVVRSFKGGF
CHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
SGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELA
CCCHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHH
GVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAM
HHHHCCEEECCCCCEEEECCCCEEEHHCCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHH
FGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCC
PGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDALLERLPAAGVSLQTTRLAS
CCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230