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The map label for this gene is rocD [H]

Identifier: 148823521

GI number: 148823521

Start: 2604942

End: 2605493

Strand: Reverse

Name: rocD [H]

Synonym: TBFG_12344

Alternate gene names: 148823521

Gene position: 2605493-2604942 (Counterclockwise)

Preceding gene: 148823522

Following gene: 148823520

Centisome position: 58.89

GC content: 64.67

Gene sequence:

>552_bases
GTGCTGATGATCGCCGACGAAATCCAATCGGGGCTGGCCTGTACGGGTTACCCGTTCGCCTGCGACCACGGGGGTGTGCT
GCCAGACATTTACCTGCTCGGCAAGACACTTGGTGGCGGTGCGGTTCCGTTGTCGGCGATGGTCGCGGACCGCGAAATCT
TCGGCGTGGTGCATCCCGGCGAACACGGGTCGACGTTCGGCGGCAATCCGTTGGCCGCCGCGATCGGTACCCCCGTGGTT
TCCATGGTCGTCTGGGGAGAATGTCAAGCTCGCTCCGCTAAATTGGGTGCGCATCTGCATCAGCGCCTGGCGGACCTGAT
CGGCGATGGTGCGGTGGCCCTGCGCGGCCTCGGATGGTGGGCTGACGTCGACATCGAACGGGCGCTTGCCATTGGCACAG
ACATGAGCATGCGGTTGGCCGATCGCGGTGTGCTGTTAAAAGACACCTACGGCGCCGCCCTGCGGTTCGCGCCGCCGTTA
GTGATCACCGCGCAGGAGATCGACTGCGCGGTTCGCCGGTTCGCCGACGCGCTATGGGAGGCGGGTTCATAA

Upstream 100 bases:

>100_bases
TCGACGACAACACCGTCGCTGACCTGCTCGAGCCGATTCCCGGCCAGGCGGGCATCATCGTCCCGGCCGACGACTACCTG
CCGGCTGCGTCGAGCACAAC

Downstream 100 bases:

>100_bases
TTGCCGACAACGTCGATGAGCCTTCGAGAACTGATGCTGCGGCGCCGCCCGGTGAGCGGCGCCCCGGTCGCATCCGGGGC
ATCGGGGAACCTCAAGCGGA

Product: ornithine aminotransferase (C-terminus part) rocD2

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLMIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEHGSTFGGNPLAAAIGTPVV
SMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPL
VITAQEIDCAVRRFADALWEAGS

Sequences:

>Translated_183_residues
MLMIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEHGSTFGGNPLAAAIGTPVV
SMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPL
VITAQEIDCAVRRFADALWEAGS
>Mature_183_residues
MLMIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEHGSTFGGNPLAAAIGTPVV
SMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPL
VITAQEIDCAVRRFADALWEAGS

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde. Controls arginine catabolism [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=173, Percent_Identity=41.0404624277457, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI284507298, Length=168, Percent_Identity=42.2619047619048, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI13994255, Length=195, Percent_Identity=30.2564102564103, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1789759, Length=184, Percent_Identity=35.8695652173913, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI145693181, Length=184, Percent_Identity=33.695652173913, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1787560, Length=190, Percent_Identity=35.7894736842105, Blast_Score=88, Evalue=3e-19,
Organism=Escherichia coli, GI1786991, Length=174, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788044, Length=179, Percent_Identity=32.9608938547486, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1789016, Length=194, Percent_Identity=28.3505154639175, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25144271, Length=170, Percent_Identity=37.0588235294118, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=170, Percent_Identity=37.0588235294118, Blast_Score=116, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=193, Percent_Identity=30.0518134715026, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992977, Length=188, Percent_Identity=31.9148936170213, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=186, Percent_Identity=34.9462365591398, Blast_Score=107, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6324432, Length=183, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357415, Length=167, Percent_Identity=37.7245508982036, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574759, Length=197, Percent_Identity=32.48730964467, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161085790, Length=194, Percent_Identity=30.9278350515464, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 19125; Mature: 19125

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPG
CEEEHHHHHCCCEECCCCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHCHHEEEEECCC
EHGSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWW
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCE
ADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVITAQEIDCAVRRFADALWE
ECCCHHHHHHCCCCCEEEHHCCCEEEECCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHC
AGS
CCC
>Mature Secondary Structure
MLMIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPG
CEEEHHHHHCCCEECCCCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHCHHEEEEECCC
EHGSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWW
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCE
ADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVITAQEIDCAVRRFADALWE
ECCCHHHHHHCCCCCEEEHHCCCEEEECCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHC
AGS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7540694; 9384377; 8113162 [H]