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The map label for this gene is hisD [H]

Identifier: 148822806

GI number: 148822806

Start: 1794956

End: 1796290

Strand: Direct

Name: hisD [H]

Synonym: TBFG_11615

Alternate gene names: 148822806

Gene position: 1794956-1796290 (Clockwise)

Preceding gene: 148822804

Following gene: 148822807

Centisome position: 40.57

GC content: 69.81

Gene sequence:

>1335_bases
GTGACCGCGCCGCCGCCCGTGCTTACCCGTATCGACTTGCGGGGAGCCGAGTTGACAGCTGCCGAGCTGCGGGCCGCTCT
GCCACGCGGCGGCGCCGATGTGGAAGCCGTGCTGCCGACGGTACGGCCCATTGTGGCGGCCGTCGCCGAGCGCGGGGCCG
AGGCCGCGCTGGACTTCGGCGCATCGTTCGACGGTGTGCGGCCCCATGCCATCCGGGTGCCAGACGCAGCGCTGGACGCG
GTGCTGGCCGGACTGGACTGCGACGTCTGCGAAGCGTTGCAGGTGATGGTCGAGCGGACCCGCGCCGTGCACTCCGGGCA
GCGTCGCACCGACGTCACAACCACACTGGGCCCGGGCGCGACGGTCACCGAGCGGTGGGTTCCGGTCGAGCGGGTAGGCC
TGTACGTGCCGGGGGGCAATGCGGTGTACCCATCCAGCGTGGTGATGAACGTGGTGCCCGCCCAAGCCGCGGGCGTCGAC
TCGTTGGTGGTAGCCAGCCCGCCGCAGGCGCAGTGGGATGGAATGCCGCATCCGACCATTCTGGCCGCGGCCCGGCTGCT
GGGCGTCGATGAGGTCTGGGCGGTCGGCGGCGCTCAGGCGGTGGCGTTGCTGGCTTACGGCGGCACCGACACCGACGGCG
CAGCACTGACACCGGTCGACATGATCACCGGGCCTGGCAACATCTATGTCACGGCCGCCAAGCGACTGTGCCGTTCGCGG
GTGGGCATCGACGCCGAAGCGGGGCCAACCGAGATCGCTATCCTCGCCGATCACACCGCCGACCCGGTGCATGTGGCCGC
CGACCTGATTAGCCAGGCCGAACACGACGAGTTGGCTGCCAGCGTGCTGGTCACTCCGAGTGAGGACCTGGCCGATGCCA
CCGACGCCGAACTGGCTGGCCAGCTGCAGACTACGGTGCACCGCGAACGGGTGACGGCCGCGCTGACCGGACGCCAATCG
GCGATCGTCCTGGTCGACGACGTGGACGCCGCCGTCTTGGTGGTGAACGCTTACGCCGCTGAGCATTTGGAGATTCAGAC
CGCCGATGCCCCGCAGGTTGCCAGCCGGATCCGCTCGGCGGGAGCCATTTTCGTCGGCCCGTGGTCCCCGGTGAGCCTCG
GCGACTACTGCGCGGGATCCAACCATGTACTGCCGACCGCGGGCTGCGCCCGGCATTCCAGCGGCCTGTCGGTGCAGACG
TTCCTGCGCGGCATCCACGTCGTGGAATACACGGAGGCGGCCCTCAAAGACGTTTCCGGACACGTGATCACGCTCGCCAC
GGCCGAGGACTTGCCGGCGCACGGTGAGGCGGTACGGCGGAGGTTCGAGCGATGA

Upstream 100 bases:

>100_bases
GGTGATCCTTTGCGGACATGGCGGCTCCTCTTTGCCGGTCCTTTCTACTGCACTGTACCGGTCAGATATCGACTTGAGCT
GCTCTGGGAGAATGGTCTAC

Downstream 100 bases:

>100_bases
CCAGGTCCGGACACCCGGTTACATTGGACGACTTGCCGCTGCGCGCCGACTTGCGTGGTAAAGCACCATACGGTGCACCG
CAATTAGCTGTTCCGGTACG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDA
VLAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVD
SLVVASPPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSR
VGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQS
AIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQT
FLRGIHVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER

Sequences:

>Translated_444_residues
MTAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDA
VLAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVD
SLVVASPPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSR
VGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQS
AIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQT
FLRGIHVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER
>Mature_443_residues
TAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDAV
LAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDS
LVVASPPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRV
GIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSA
IVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTF
LRGIHVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=37.5609756097561, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=35.796766743649, Blast_Score=233, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45969; Mature: 45838

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFG
CCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCC
ASFDGVRPHAIRVPDAALDAVLAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGA
CCCCCCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
TVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQWDGMPHPTI
CHHHCCCCHHHEEEEECCCCCCCCCHHHHEECCCHHCCCCEEEEECCCCHHCCCCCCHHH
LAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSR
HHHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCEECCHHEEECCCCEEEHHHHHHHHHH
VGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAG
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEECCCHHHCCCCCHHHHH
QLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSA
HHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEHHHHCCEEEECCCCHHHHHHHHHC
GAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSG
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
HVITLATAEDLPAHGEAVRRRFER
CEEEEEECCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFG
CCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCC
ASFDGVRPHAIRVPDAALDAVLAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGA
CCCCCCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
TVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQWDGMPHPTI
CHHHCCCCHHHEEEEECCCCCCCCCHHHHEECCCHHCCCCEEEEECCCCHHCCCCCCHHH
LAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSR
HHHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCEECCHHEEECCCCEEEHHHHHHHHHH
VGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAG
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEECCCHHHCCCCCHHHHH
QLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSA
HHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEHHHHCCEEEECCCCHHHHHHHHHC
GAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSG
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
HVITLATAEDLPAHGEAVRRRFER
CEEEEEECCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]