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The map label for this gene is coaBC [H]

Identifier: 148822611

GI number: 148822611

Start: 1569785

End: 1571038

Strand: Direct

Name: coaBC [H]

Synonym: TBFG_11420

Alternate gene names: 148822611

Gene position: 1569785-1571038 (Clockwise)

Preceding gene: 148822610

Following gene: 148822612

Centisome position: 35.48

GC content: 67.78

Gene sequence:

>1254_bases
GTGGACCATAAACGGATCCCCAAGCAGGTAATAGTCGGTGTCTCCGGGGGCATCGCCGCCTACAAGGCGTGCACGGTTGT
TCGTCAACTCACCGAGGCCAGTCATCGCGTCCGAGTCATTCCCACCGAATCCGCCCTGCGCTTCGTCGGTGCCGCGACCT
TCGAGGCGCTCTCCGGTGAGCCGGTGTGCACCGACGTTTTCGCCGACGTTCCGGCGGTCCCGCATGTTCACCTCGGCCAG
CAGGCCGATCTGGTCGTAGTGGCGCCGGCCACCGCCGACCTGCTGGCCCGCGCGGCGGCCGGTCGAGCCGACGATCTGCT
GACCGCGACGCTGCTGACGGCGCGGTGTCCGGTGCTGTTCGCGCCGGCGATGCACACCGAGATGTGGTTGCATCCGGCCA
CCGTCGACAACGTGGCCACGCTGCGCCGCCGCGGCGCGGTGGTGCTCGAGCCCGCGACAGGACGGCTTACCGGCGCCGAC
AGCGGGGCCGGCCGACTGCCCGAGGCGGAGGAGATCACCACCCTCGCCCAGCTGCTGCTGGAGCGGCACGACGCCCTGCC
CTACGATCTCGCGGGGCGAAAGCTGCTGGTTACCGCCGGTGGCACACGCGAGCCGATCGATCCGGTGCGCTTTATCGGCA
ACCGCAGCTCCGGCAAGCAGGGCTATGCGGTGGCGCGGGTGGCCGCCCAGCGCGGCGCCGACGTTACTTTGATCGCTGGG
CATACCGCAGGGCTCGTCGATCCCGCCGGCGTCGAGGTGGTGCACGTCAGCTCGGCCCAGCAACTCGCCGACGCGGTGTC
CAAGCACGCTCCGACCGCCGACGTATTGGTGATGGCGGCGGCCGTCGCCGACTTCCGGCCCGCGCAGGTTGCCACCGCCA
AAATCAAGAAAGGCGTCGAAGGCCCACCGACCATCGAGCTGCTGCGCAACGACGACGTGCTGGCCGGGGTGGTGCGGGCC
CGAGCCCATGGACAACTGCCCAACATGCGGGCCATTGTGGGCTTCGCAGCCGAGACCGGCGACGCCAATGGCGACGTGCT
CTTTCATGCCCGAGCTAAACTGCGACGCAAAGGCTGCGATCTGTTAGTCGTCAATGCCGTCGGCGAAGGCAGGGCCTTTG
AGGTAGACAGCAACGACGGCTGGCTACTGGCGTCCGATGGTACCGAGTCGGCATTGCAGCACGGCTCCAAGACACTGATG
GCGAGCCGTATCGTTGATGCAATCGTCACGTTCCTGGCAGGCTGTAGCAGCTAA

Upstream 100 bases:

>100_bases
GCCGGGGTTGCAAGAGAAGCCGTTGTCCATCGCGTTGCGCGAGATCCACGCCGATCTGCTCGAGCACACCGAGGGCGAGT
AGCAGGGCAGGCCTGAGGTG

Downstream 100 bases:

>100_bases
CGGGTCCGGCGGCCGGTTCTGTACGGGTCCTGGACAGGTGCTGGACGATCCCTTGCTCGATTGGACGAGCTGAGATTGAT
GCCTGAGGATATAATTCGGC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQ
QADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGAD
SGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAG
HTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRA
RAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLM
ASRIVDAIVTFLAGCSS

Sequences:

>Translated_417_residues
MDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQ
QADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGAD
SGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAG
HTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRA
RAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLM
ASRIVDAIVTFLAGCSS
>Mature_417_residues
MDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQ
QADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGAD
SGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAG
HTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRA
RAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLM
ASRIVDAIVTFLAGCSS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=182, Percent_Identity=32.967032967033, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082301, Length=408, Percent_Identity=39.9509803921569, Blast_Score=227, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24657262, Length=181, Percent_Identity=27.6243093922652, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43478; Mature: 43478

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGE
CCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCC
PVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLF
CCHHHHHHCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEE
APAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSGAGRLPEAEEITTLAQLLL
CCCHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHH
ERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAG
HHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEC
HTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVE
CCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCD
CCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHCCCC
LLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLMASRIVDAIVTFLAGCSS
EEEEEECCCCEEEEECCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGE
CCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCC
PVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLF
CCHHHHHHCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEE
APAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSGAGRLPEAEEITTLAQLLL
CCCHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHH
ERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAG
HHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEC
HTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVE
CCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCD
CCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHCCCC
LLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLMASRIVDAIVTFLAGCSS
EEEEEECCCCEEEEECCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]