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The map label for this gene is ispD [H]

Identifier: 148663446

GI number: 148663446

Start: 4033010

End: 4033705

Strand: Reverse

Name: ispD [H]

Synonym: MRA_3621

Alternate gene names: 148663446

Gene position: 4033705-4033010 (Counterclockwise)

Preceding gene: 148663447

Following gene: 148663445

Centisome position: 91.26

GC content: 66.09

Gene sequence:

>696_bases
GTGGTCAGGGAAGCGGGCGAAGTAGTTGCGATCGTCCCGGCTGCGGGGTCGGGGGAGCGGTTGGCCGTCGGTGTGCCCAA
GGCGTTTTACCAGCTCGACGGGCAGACTCTCATTGAGCGGGCCGTCGATGGCCTGCTGGATTCGGGGGTAGTTGACACCG
TTGTTGTGGCCGTGCCCGCCGACCGTACGGACGAGGCGAGGCAGATCCTCGGCCACAGGGCGATGATTGTGGCGGGTGGG
TCGAATCGCACTGACACCGTGAACCTGGCGCTGACAGTGCTGTCCGGGACCGCGGAGCCGGAGTTTGTGCTTGTGCATGA
TGCCGCGCGGGCACTGACACCACCGGCCCTGGTCGCCCGGGTGGTCGAGGCGTTGCGGGACGGTTATGCCGCCGTCGTTC
CCGTACTGCCGCTTTCTGACACCATCAAGGCCGTGGATGCCAACGGGGTGGTCCTGGGCACGCCGGAACGAGCCGGGCTG
CGGGCCGTGCAGACCCCACAAGGGTTCACTACCGACCTGCTGCTGCGGTCATATCAGCGCGGCTCCCTAGACCTTCCAGC
CGCCGAGTACACCGATGACGCGTCGCTGGTCGAGCATATCGGCGGCCAGGTGCAGGTGGTCGACGGCGATCCGCTGGCGT
TCAAGATCACCACCAAACTGGATCTGTTGCTGGCCCAAGCTATAGTGCGCGGGTGA

Upstream 100 bases:

>100_bases
GTCGGCGAGTTGGCGTTGGCTGAGAGCACCGATGACGCCAAAGCCGAGACCATCCTTGACGAGGTTTTAGCCGCCGCGTC
TTGACCGCCCTGAGGCTCTA

Downstream 100 bases:

>100_bases
ATCAGCTGCCCCGCGTTGGTTTGGGGACCGATGTGCATCCGATCGAACCCGGACGTCCGTGCTGGCTGGTAGGGTTGTTG
TTCCCGAGCGCCGACGGTTG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPADRTDEARQILGHRAMIVAGG
SNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGL
RAVQTPQGFTTDLLLRSYQRGSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG

Sequences:

>Translated_231_residues
MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPADRTDEARQILGHRAMIVAGG
SNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGL
RAVQTPQGFTTDLLLRSYQRGSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG
>Mature_231_residues
MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPADRTDEARQILGHRAMIVAGG
SNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVARVVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGL
RAVQTPQGFTTDLLLRSYQRGSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=239, Percent_Identity=28.8702928870293, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1789104, Length=223, Percent_Identity=32.7354260089686, Blast_Score=94, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 24074; Mature: 24074

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPA
CCCCCCCEEEEEECCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHCCCCHHEEEEEECC
DRTDEARQILGHRAMIVAGGSNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVAR
CCCHHHHHHHCCEEEEEECCCCCCEEEEEEEEEEECCCCCCEEEEECCHHHCCCHHHHHH
VVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQR
HHHHHHCCCEEEEEECCCCCHHEEECCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHCC
GSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG
CCCCCCCCCCCCCHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDGLLDSGVVDTVVVAVPA
CCCCCCCEEEEEECCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHCCCCHHEEEEEECC
DRTDEARQILGHRAMIVAGGSNRTDTVNLALTVLSGTAEPEFVLVHDAARALTPPALVAR
CCCHHHHHHHCCEEEEEECCCCCCEEEEEEEEEEECCCCCCEEEEECCHHHCCCHHHHHH
VVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGLRAVQTPQGFTTDLLLRSYQR
HHHHHHCCCEEEEEECCCCCHHEEECCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHCC
GSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITTKLDLLLAQAIVRG
CCCCCCCCCCCCCHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]