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The map label for this gene is apt [H]

Identifier: 148662423

GI number: 148662423

Start: 2922197

End: 2922868

Strand: Reverse

Name: apt [H]

Synonym: MRA_2613

Alternate gene names: 148662423

Gene position: 2922868-2922197 (Counterclockwise)

Preceding gene: 148662424

Following gene: 148662422

Centisome position: 66.13

GC content: 69.05

Gene sequence:

>672_bases
GTGTGCCATGGCGGTACATGGGCTGGTGACTACGTGTTGAACGTGATCGCGACGGGGCTCTCCTTAAAGGCACGGGGGAA
GCGCCGCCGGCAGCGTTGGGTCGACGACGGGCGGGTATTGGCGCTCGGTGAGTCCCGCCGGAGCTCAGCCATATCTGTGG
CCGACGTGGTTGCGTCGCTGACCCGGGATGTGGCCGACTTTCCGGTTCCCGGCGTCGAGTTCAAGGACCTCACCCCGCTA
TTCGCCGACCGAAGAGGATTGGCCGCGGTAACCGAAGCGCTGGCCGATCGGGCGTCCGGAGCTGACCTGGTGGCCGGCGT
CGACGCCCGCGGGTTTCTGGTGGCAGCCGCGGTCGCCACCCGGCTCGAAGTGGGTGTGCTGGCCGTTCGCAAGGGCGGCA
AGCTGCCCCGGCCGGTGCTCAGCGAGGAGTACTACAGGGCGTACGGCGCCGCCACTCTGGAGATTCTCGCTGAGGGCATC
GAGGTTGCGGGCCGCCGTGTCGTGATCATTGACGACGTGTTAGCAACCGGCGGCACCATCGGCGCGACGCGACGCCTGCT
TGAGCGCGGTGGCGCCAACGTGGCCGGGGCGGCCGTAGTGGTGGAACTTGCGGGGTTGAGCGGTCGCGCGGCGCTCGCAC
CGCTGCCGGTGCACAGCCTGAGCCGCCTGTGA

Upstream 100 bases:

>100_bases
TGGCCAGTGCCATCTGCAGGTAATTGACAGAATTCCACGACGAGAAGCGGACCTATCGGAGCGTAGTGTCGCAGGTGCTC
CGGGCTGTCTGGGAGAGGAT

Downstream 100 bases:

>100_bases
GGGATATCCTCTAGGTCGGAGGTGACGAACGTGGCCGAGGACCAGCTCACGGCGCAAGCGGTTGCACCGCCCACGGAGGC
TTCTGCGGCTCTCGAGCCCG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPL
FADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGI
EVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL

Sequences:

>Translated_223_residues
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPL
FADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGI
EVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL
>Mature_223_residues
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPL
FADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGI
EVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=176, Percent_Identity=42.0454545454545, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=40.6015037593985, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1786675, Length=169, Percent_Identity=41.4201183431953, Blast_Score=117, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17509087, Length=160, Percent_Identity=39.375, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323619, Length=179, Percent_Identity=33.5195530726257, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320649, Length=175, Percent_Identity=29.1428571428571, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17136334, Length=178, Percent_Identity=37.0786516853933, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 23188; Mature: 23188

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASL
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
TRDVADFPVPGVEFKDLTPLFADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVAT
HHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
RLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGIEVAGRRVVIIDDVLATGGTI
HHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCCH
GATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL
HHHHHHHHHCCCCHHHHHHEEEECCCCCCCEECCCCHHHHHCC
>Mature Secondary Structure
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASL
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
TRDVADFPVPGVEFKDLTPLFADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVAT
HHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
RLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGIEVAGRRVVIIDDVLATGGTI
HHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCCH
GATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL
HHHHHHHHHCCCCHHHHHHEEEECCCCCCCEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]