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The map label for this gene is plcC

Identifier: 148662177

GI number: 148662177

Start: 2637076

End: 2638602

Strand: Reverse

Name: plcC

Synonym: MRA_2369

Alternate gene names: 148662177

Gene position: 2638602-2637076 (Counterclockwise)

Preceding gene: 148662178

Following gene: 148662176

Centisome position: 59.7

GC content: 61.89

Gene sequence:

>1527_bases
ATGTCACGCCGAGCATTCCTGGCTAAGGCGGCTGGAGCCGGGGCAGCGGCGGTTTTGACGGACTGGGCCGCACCGGTGAT
CGAAAAGGCCTATGGTGCCGGTCCCTGCTCGGGTCATTTGACCGATATCGAGCACATCGTGCTGTGCCTACAGGAGAACA
GGTCGTTCGATCACTATTTCGGCACGCTTTCTGCCGTCGACGGGTTCGACACTCCGACGCCGCTGTTTCAACAAAAGGGC
TGGAACCCGGAGACGCAGGCGCTGGACCCCACCGGCATTACGCTGCCCTACCGCATCAATACCACCGGGGGTCCCAACGG
GGTTGGCGAGTGCGTCAACGACCCAGACCACCAGTGGATTGCCGCGCACTTGTCATGGAACGGCGGCGCCAATGACGGCT
GGCTGCCGGCGCAGGCGCGGACCCGGTCGGTGGCCAACACGCCCGTGGTGATGGGCTATTACGCACGTCCTGACATACCG
ATCCACTACTTGTTGGCCGATACCTTCACGATCTGCGACCAGTACTTCTCGTCGCTTCTTGGCGGGACGATGCCTAACCG
GCTCTATTGGATCAGCGCCACCGTCAATCCCGACGGGGATCAAGGTGGGCCGCAGATCGTCGAACCCGCCATCCAGCCGA
AGTTGACCTTCACCTGGCGCATCATGCCGCAGAACCTCAGTGACGCCGGCATCAGTTGGAAGGTGTACAACAGCAAGCTG
CTCGGCGGGCTCAACGACACTTCCTTGAGCCGTAACGGGTATGTGGGCAGTTTCAAACAGGCCGCAGATCCGAGGTCGGA
CCTGGCCCGTTATGGCATCGCCCCGGCCTACCCGTGGGATTTCATCCGCGACGTCATCAACAACACGCTGCCCCAGGTGT
CCTGGGTCGTTCCGTTGACCGTCGAGTCCGAACATCCGTCATTCCCGGTGGCAGTCGGTGCGGTGACGATCGTGAACTTG
ATAAGGGTGTTGCTGCGCAATCCGGCGGTGTGGGAGAAAACCGCGTTGATCATCGCCTATGACGAACATGGCGGCTTCTT
CGACCACGTCACACCGCTCACCGCGCCGGAGGGCACACCCGGCGAATGGATTCCCAACAGTGTTGACATCGACAAGGTCG
ACGGCTCCGGCGGAATACGTGGACCCATCGGCTTGGGCTTTCGCGTGCCCTGCTTCGTCATTTCGCCTTACAGTCGCGGC
GGGCTGATGGTCCATGATCGGTTCGACCACACATCGCAGCTGCAATTGATCGGCAAGCGTTTCGGGGTGCCGGTTCCCAA
CTTGACACCCTGGCGTGCCAGTGTCACCGGCGATATGACGTCGGCATTCAATTTCGCGGCCCCGCCGGACCCGTCGCCAC
CCAATCTGGACCACCCGGTCCGTCAATTGCCGAAGGTCGCCAAGTGCGTGCCCAATGTGGTGCTGGGTTTCTTGAACGAA
GGCCTGCCGTATCGGGTGCCCTACCCCCAAACAACGCCAGTCCAGGAATCCGGTCCCGCGCGGCCGATTCCCAGCGGCAT
CTGCTAG

Upstream 100 bases:

>100_bases
CCCAGCGGTCTCTGTTGACCCACAGTCGGCGATGGCCGCGACGGTAAGCCGAAATACACGAGGGAGAGCCGATGTGGTGA
GCCAAGGTGCATTCGCCGGA

Downstream 100 bases:

>100_bases
CCGGGGATGGTTCAGACGTAACGGTTGGCTAGGTCGAAACCCGCGCCAGGGCCGCTGGACGGGCTCATGGCAGCGAAATT
AGAAAACCCGGGATATTGTC

Product: phospholipase C 3 PlcC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKG
WNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIP
IHYLLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNSKL
LGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNL
IRVLLRNPAVWEKTALIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRG
GLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNE
GLPYRVPYPQTTPVQESGPARPIPSGIC

Sequences:

>Translated_508_residues
MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKG
WNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIP
IHYLLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNSKL
LGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNL
IRVLLRNPAVWEKTALIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRG
GLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNE
GLPYRVPYPQTTPVQESGPARPIPSGIC
>Mature_507_residues
SRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKGW
NPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIPI
HYLLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNSKLL
GGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLI
RVLLRNPAVWEKTALIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRGG
LMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNEG
LPYRVPYPQTTPVQESGPARPIPSGIC

Specific function: Unknown

COG id: COG3511

COG function: function code M; Phospholipase C

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial phospholipase C family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHLC_MYCTU (P95245)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   F70662
- RefSeq:   NP_216865.1
- RefSeq:   NP_336893.1
- ProteinModelPortal:   P95245
- EnsemblBacteria:   EBMYCT00000001985
- EnsemblBacteria:   EBMYCT00000070850
- GeneID:   886000
- GeneID:   925939
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2414
- KEGG:   mtu:Rv2349c
- TIGR:   MT2414
- TubercuList:   Rv2349c
- GeneTree:   EBGT00050000017446
- HOGENOM:   HBG565180
- OMA:   SLFDFQG
- ProtClustDB:   CLSK791798
- BRENDA:   3.1.4.3
- GO:   GO:0009405
- InterPro:   IPR007312
- InterPro:   IPR006311
- TIGRFAMs:   TIGR01409

Pfam domain/function: PF04185 Phosphoesterase

EC number: =3.1.4.3

Molecular weight: Translated: 55048; Mature: 54917

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS51318 TAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYF
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
GTLSAVDGFDTPTPLFQQKGWNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWI
HHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCEE
AAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIPIHYLLADTFTICDQYFSSLL
EEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHH
GGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNSKL
CCCCCCEEEEEEEEECCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCCCCEEEEECCHH
LGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVINNTLPQVSWVVPLT
CCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEE
VESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKTALIIAYDEHGGFFDHVTPLTAPEGTP
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHCCCCCCCCCCCC
GEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRGGLMVHDRFDHTSQLQLIGKR
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHH
FGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNE
HCCCCCCCCCCCEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GLPYRVPYPQTTPVQESGPARPIPSGIC
CCCEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYF
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
GTLSAVDGFDTPTPLFQQKGWNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWI
HHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCEE
AAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIPIHYLLADTFTICDQYFSSLL
EEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHH
GGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNSKL
CCCCCCEEEEEEEEECCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCCCCEEEEECCHH
LGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVINNTLPQVSWVVPLT
CCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEE
VESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKTALIIAYDEHGGFFDHVTPLTAPEGTP
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHCCCCCCCCCCCC
GEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRGGLMVHDRFDHTSQLQLIGKR
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHH
FGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNE
HCCCCCCCCCCCEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GLPYRVPYPQTTPVQESGPARPIPSGIC
CCCEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036