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The map label for this gene is mraY

Identifier: 148661972

GI number: 148661972

Start: 2426298

End: 2427377

Strand: Reverse

Name: mraY

Synonym: MRA_2171

Alternate gene names: 148661972

Gene position: 2427377-2426298 (Counterclockwise)

Preceding gene: 148661973

Following gene: 148661971

Centisome position: 54.92

GC content: 65.46

Gene sequence:

>1080_bases
ATGAGGCAGATCCTTATCGCCGTTGCCGTAGCGGTGACGGTGTCCATCTTGCTGACCCCGGTGCTGATCCGGTTGTTCAC
TAAGCAGGGCTTCGGCCACCAGATCCGTGAGGATGGCCCGCCCAGCCACCACACCAAGCGCGGTACGCCGTCGATGGGCG
GGGTGGCGATTCTGGCCGGCATCTGGGCGGGCTACCTGGGCGCCCACCTAGCGGGCCTGGCGTTTGACGGTGAAGGCATC
GGCGCATCGGGTCTGTTGGTGCTGGGCCTAGCCACCGCTTTGGGCGGCGTCGGGTTCATCGACGATCTGATCAAGATCCG
CAGGTCGCGCAATCTCGGGTTGAACAAGACGGCCAAGACCGTCGGGCAGATCACCTCCGCCGTGCTGTTTGGCGTGCTGG
TGCTGCAGTTCCGGAATGCTGCCGGCCTGACACCGGGCAGCGCGGATCTGTCCTACGTGCGTGAGATCGCCACCGTCACA
TTGGCGCCGGTGCTGTTCGTGTTGTTCTGCGTGGTCATCGTCAGCGCCTGGTCGAACGCGGTCAACTTCACCGATGGCCT
GGACGGGCTGGCCGCCGGCACCATGGCGATGGTCACCGCCGCCTACGTGCTGATCACCTTCTGGCAGTACCGCAACGCGT
GCGTGACGGCGCCGGGCCTGGGCTGCTACAACGTGCGCGACCCGCTGGACCTGGCGCTCATCGCGGCCGCAACCGCTGGC
GCCTGCATCGGTTTTTTGTGGTGGAACGCCGCGCCCGCCAAGATCTTCATGGGTGACACTGGGTCGCTGGCGTTGGGCGG
CGTCATCGCGGGGTTGTCGGTGACCAGCCGCACCGAGATCCTTGCGGTGGTGCTGGGTGCGCTGTTCGTCGCCGAGATCA
CCTCGGTGGTGTTGCAAATCCTGACCTTCCGGACCACCGGGCGCCGGATGTTTCGGATGGCGCCCTTCCACCACCATTTC
GAGTTGGTCGGTTGGGCTGAAACCACGGTCATCATCCGGTTCTGGCTGCTCACCGCGATCACCTGCGGTCTGGGCGTGGC
CTTGTTCTACGGTGAGTGGCTTGCCGCGGTCGGTGCCTGA

Upstream 100 bases:

>100_bases
GACCCGGGGATGTGGTCTTGGTCAAGGCCTCGAACGCGGCCGGGCTGGGTGCGGTGGCCGATGCATTGGTCGCAGACGAC
ACATGCGGGAGTGTGCGCCC

Downstream 100 bases:

>100_bases
CGTGCTTGACCCTCTGGGGCCGGGTGCGCCCGTGTTGGTAGCCGGTGGCCGGGTGACCGGTCAGGCGGTGGCCGCGGTGC
TGACTCGGTTTGGTGCGACG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGI
GASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVT
LAPVLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAG
ACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHF
ELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA

Sequences:

>Translated_359_residues
MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGI
GASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVT
LAPVLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAG
ACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHF
ELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA
>Mature_359_residues
MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGI
GASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVT
LAPVLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAG
ACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHF
ELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=349, Percent_Identity=34.0974212034384, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_MYCBO (P64260)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855829.1
- ProteinModelPortal:   P64260
- EnsemblBacteria:   EBMYCT00000017950
- GeneID:   1091254
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2180c
- GeneTree:   EBGT00050000016928
- HOGENOM:   HBG708263
- OMA:   TFWQFRN
- ProtClustDB:   PRK00108
- BioCyc:   MBOV233413:MB2180C-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 37714; Mature: 37714

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e3280b4)-; HASH(0x1d59dea8)-; HASH(0x1db99d94)-; HASH(0x1d59dd64)-; HASH(0x1d59dc98)-; HASH(0x1cfc750c)-; HASH(0x1e0a0900)-; HASH(0x1e0dc280)-; HASH(0x1db99ec0)-; HASH(0x1db99ef0)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
IWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKT
HHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
VGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVTLAPVLFVLFCVVIVSAWSNA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHH
ACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQI
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA
HHHHHCCHHHHHCCCCHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHHTKRGTPSMGGVAILAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
IWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDDLIKIRRSRNLGLNKTAKT
HHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
VGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVTLAPVLFVLFCVVIVSAWSNA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLALIAAATAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHH
ACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTSRTEILAVVLGALFVAEITSVVLQI
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRFWLLTAITCGLGVALFYGEWLAAVGA
HHHHHCCHHHHHCCCCHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972