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The map label for this gene is ytfL [C]

Identifier: 148661647

GI number: 148661647

Start: 2099613

End: 2100650

Strand: Reverse

Name: ytfL [C]

Synonym: MRA_1852

Alternate gene names: 148661647

Gene position: 2100650-2099613 (Counterclockwise)

Preceding gene: 148661648

Following gene: 148661646

Centisome position: 47.53

GC content: 64.84

Gene sequence:

>1038_bases
ATGGATGTGCTGTCCGCGGTGTTGCTGGCGCTTTTGCTGATCGGCGCCAACGCGTTCTTCGTGGGCGCGGAATTCGCGTT
GATCTCGGCGCGTCGTGACCGCCTCGAAGCGCTGGCCGAGCAGGGCAAGGCCACTGCCGTCACCGTGATCCGGGCGGGCG
AACAGCTCCCGGCGATGCTGACCGGCGCACAGCTGGGGGTTACGGTGTCCTCGATCCTGCTTGGCCGGGTCGGCGAACCG
GCAGTCGTCAAGCTGCTACAGCTGTCGTTCGGGCTGAGCGGTGTACCGCCGGCGCTGCTGCACACCTTGTCGTTGGCGAT
CGTGGTGGCGCTGCATGTCCTGCTCGGTGAGATGGTGCCGAAGAACATCGCTTTGGCTGGTCCGGAGCGAACAGCGATGT
TGCTGGTCCCGCCGTACCTGGTCTACGTGCGCCTCGCCCGGCCGTTCATCGCGTTCTACAACAACTGCGCCAACGCGATA
CTGCGGCTGGTTGGGGTGCAGCCGAAGGATGAACTCGACATCGCCGTCTCCACTGCGGAACTGTCCGAGATGATCGCCGA
ATCGCTATCCGAAGGCCTGCTGGATCACGAGGAGCACACGCGGCTAACCCGAGCCCTTCGGATTCGAACTCGCCTGGTTG
CCGATGTCGCGGTGCCGCTGGTCAACATTCGGGCAGTGCAGGTGTCGGCGGTAGGGTCCGGGCCCACCATCGGCGGGGTC
GAACAGGCCTTGGCGCAAACCGGCTACTCCCGCTTTCCGGTGGTGGATCGCGGTGGAAGGTTCATCGGATATCTGCACAT
CAAGGACGTGCTGACCCTCGGTGACAATCCGCAAACCGTGATCGATCTGGCCGTTGTGCGCCCGCTGCCGCGGGTTCCCC
AATCGTTGCCGCTGGCCGACGCCCTGTCGCGGATGCGGCGCATCAACAGCCATCTGGCCTTGGTAACCGCCGACAACGGT
TCTGTCGTGGGGATGGTGGCGCTGGAGGACGTGGTGGAGGACCTGGTTGGCACCATGCGCGACGGGACGCATCGTTGA

Upstream 100 bases:

>100_bases
GGTTAGCCACCGTGATCCAGATGGACGGGCGCCGGATCGACTTGTTGGAGTTGATCAAAATGGGCGGCCATGCCGACCCC
GGGTCGGGGCGGGGCCGCTG

Downstream 100 bases:

>100_bases
CTGACGCAGGGATCGGTGTCTGACGGGACACCGAGCGTAATCGGGGGCTGCTGCCGCTGACAATCGTTTCGGATCAGTTG
GCCCGAACGCCGGACGTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKATAVTVIRAGEQLPAMLTGAQLGVTVSSILLGRVGEP
AVVKLLQLSFGLSGVPPALLHTLSLAIVVALHVLLGEMVPKNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANAI
LRLVGVQPKDELDIAVSTAELSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAVPLVNIRAVQVSAVGSGPTIGGV
EQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDNPQTVIDLAVVRPLPRVPQSLPLADALSRMRRINSHLALVTADNG
SVVGMVALEDVVEDLVGTMRDGTHR

Sequences:

>Translated_345_residues
MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKATAVTVIRAGEQLPAMLTGAQLGVTVSSILLGRVGEP
AVVKLLQLSFGLSGVPPALLHTLSLAIVVALHVLLGEMVPKNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANAI
LRLVGVQPKDELDIAVSTAELSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAVPLVNIRAVQVSAVGSGPTIGGV
EQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDNPQTVIDLAVVRPLPRVPQSLPLADALSRMRRINSHLALVTADNG
SVVGMVALEDVVEDLVGTMRDGTHR
>Mature_345_residues
MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKATAVTVIRAGEQLPAMLTGAQLGVTVSSILLGRVGEP
AVVKLLQLSFGLSGVPPALLHTLSLAIVVALHVLLGEMVPKNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANAI
LRLVGVQPKDELDIAVSTAELSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAVPLVNIRAVQVSAVGSGPTIGGV
EQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDNPQTVIDLAVVRPLPRVPQSLPLADALSRMRRINSHLALVTADNG
SVVGMVALEDVVEDLVGTMRDGTHR

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI310128564, Length=336, Percent_Identity=31.25, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1790664, Length=343, Percent_Identity=24.4897959183673, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI145693175, Length=327, Percent_Identity=23.2415902140673, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87082033, Length=190, Percent_Identity=27.8947368421053, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1841_MYCTU (Q50593)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   A70664
- RefSeq:   NP_216357.1
- RefSeq:   NP_336346.1
- ProteinModelPortal:   Q50593
- SMR:   Q50593
- EnsemblBacteria:   EBMYCT00000000708
- EnsemblBacteria:   EBMYCT00000069090
- GeneID:   885656
- GeneID:   923728
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1889
- KEGG:   mtu:Rv1841c
- TIGR:   MT1889
- TubercuList:   Rv1841c
- GeneTree:   EBGT00050000016975
- HOGENOM:   HBG673071
- OMA:   HILLGEM
- ProtClustDB:   CLSK791425
- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR002550
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF01595 DUF21

EC number: NA

Molecular weight: Translated: 36686; Mature: 36686

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ee2c2e8)-; HASH(0x1b2beebc)-; HASH(0x1e9ecfec)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKATAVTVIRAGEQLPAML
CCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
TGAQLGVTVSSILLGRVGEPAVVKLLQLSFGLSGVPPALLHTLSLAIVVALHVLLGEMVP
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
KNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANAILRLVGVQPKDELDIAVSTAE
CCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
LSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAVPLVNIRAVQVSAVGSGPTIGGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCHH
EQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDNPQTVIDLAVVRPLPRVPQSLPLAD
HHHHHHCCCCCCCEEECCCCEEEEEEEEEHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHH
ALSRMRRINSHLALVTADNGSVVGMVALEDVVEDLVGTMRDGTHR
HHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKATAVTVIRAGEQLPAML
CCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
TGAQLGVTVSSILLGRVGEPAVVKLLQLSFGLSGVPPALLHTLSLAIVVALHVLLGEMVP
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
KNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANAILRLVGVQPKDELDIAVSTAE
CCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
LSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAVPLVNIRAVQVSAVGSGPTIGGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCHH
EQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDNPQTVIDLAVVRPLPRVPQSLPLAD
HHHHHHCCCCCCCEEECCCCEEEEEEEEEHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHH
ALSRMRRINSHLALVTADNGSVVGMVALEDVVEDLVGTMRDGTHR
HHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036