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The map label for this gene is PE_PGRS34

Identifier: 148661646

GI number: 148661646

Start: 2097903

End: 2099450

Strand: Reverse

Name: PE_PGRS34

Synonym: MRA_1851

Alternate gene names: 148661646

Gene position: 2099450-2097903 (Counterclockwise)

Preceding gene: 148661647

Following gene: 148661645

Centisome position: 47.5

GC content: 75.65

Gene sequence:

>1548_bases
ATGTCGTTTGTGGTGGCGGCCCCAGAAGTGGTGGTGGCGGCGGCGTCGGATTTGGCCGGCATCGGGTCGGCGATCGGCGC
GGCGAATGCGGCTGCGGCCGTGCCCACGATGGGGGTGCTGGCCGCGGGCGCCGATGAGGTGTCGGCGGCTGTTGCGGATT
TGTTCGGCGCGCACGCCCAGGCCTATCAGGCATTGAGTGCGCAGGCGGCGCTGTTTCACGAGCAGTTTGTGCATGCCATG
ACCGCCGGCGCGGGGGCCTATGCCGGTGCCGAGGCGGCGGACGCCGCCGCGCTGGACGTGCTCAACGGGCCGTTTCAGGC
GTTGTTCGGCCGCCCGTTGATCGGTGATGGCGCCAATGGCGCGCCGGGACAGCCCGGCGGGCCCGGCGGGTTGCTGTACG
GCAACGGCGGCAACGGCGGCAACGGCGGGATCGGCCAGCCCGGCGGCGCCGGTGGGGATGCAGGGTTGATCGGCAACGGC
GGCAACGGTGGCATCGGCGGGCCCGGGGCGACCGGCCTTGCCGGTGGTGCCGGCGGGGTCGGCGGACTGCTCTTCGGCGA
CGGCGGCAACGGCGGTGCCGGCGGACTCGGTACCGGACCCGTCGGCGCTACCGGTGGGATCGGCGGGCCCGGTGGAGCCG
CCGTCGGGCTGTTCGGCCATGGCGGGGCCGGCGGGGCCGGCGGGCTCGGCAAGGCCGGCTTCGCGGGCGGGGCCGGCGGC
ACCGGCGGCACCGGCGGACTGCTGTACGGCAACGGCGGCAACGGCGGCAATGTCCCATCGGGAGCCGCCGACGGCGGAGC
GGGCGGTGACGCCCGGCTGATCGGCAACGGGGGCGACGGCGGCTCCGTCGGTGCCGCCCCCACCGGCATCGGCAACGGCG
GCAACGGCGGCAACGGCGGGTGGCTGTACGGCGACGGCGGTTCCGGAGGCAGCACCCTGCAAGGTTTCAGCGACGGTGGT
ACCGGCGGTAACGCCGGGATGTTCGGCGACGGCGGTAACGGCGGGTTCAGCTTCTTCGATGGCAACGGCGGCGACGGCGG
CACCGGCGGGACGCTGATCGGCAACGGCGGCGACGGCGGCAACAGCGTGCAAACCGACGGCTTTCTCCGAGGCCACGGCG
GCGACGGCGGCAACGCCGTCGGGCTGATCGGCAACGGTGGCGCCGGAGGCGCCGGGTCCGCCGGTACCGGCGTCTTCGCC
CCCGGCGGTGGCAGTGGCGGGAACGGAGGCAACGGCGCGCTGCTGGTCGGCAACGGTGGCGCCGGCGGCTCCGGTGGGCC
AACCCAGATTCCCTCAGTCGCGGTACCCGTCACCGGCGCCGGCGGCACCGGGGGTAACGGCGGCACGGCCGGGTTGATCG
GCAACGGTGGCAATGGCGGCGCCGCCGGCGTCAGCGGGGACGGCACCCCCGGCACCGGCGGTAACGGCGGCTACGCCCAG
TTGATCGGCGACGGCGGCGACGGTGGGCCCGGCGACTCTGGCGGGCCGGGCGGCAGCGGCGGTACGGGCGGAACGCTGGC
CGGCCAGAACGGGTCCCCCGGGGGATAG

Upstream 100 bases:

>100_bases
ATCGTTTCGGATCAGTTGGCCCGAACGCCGGACGTGGTGGCGGGACGTCAATACGCTGTAACCGCTGGGACTGCGCACCC
GGTCCCGTGAGGAGCGCGTC

Downstream 100 bases:

>100_bases
CTCCCGCGCGCAGGCGAGCTGGATTCATACACCCGTATGAGCTGTATACACTCATGCTATGAGTAAGCGCCTGCAGGTTC
TGCTGGACCCCGACGAGTGG

Product: PE-PGRS family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGADEVSAAVADLFGAHAQAYQALSAQAALFHEQFVHAM
TAGAGAYAGAEAADAAALDVLNGPFQALFGRPLIGDGANGAPGQPGGPGGLLYGNGGNGGNGGIGQPGGAGGDAGLIGNG
GNGGIGGPGATGLAGGAGGVGGLLFGDGGNGGAGGLGTGPVGATGGIGGPGGAAVGLFGHGGAGGAGGLGKAGFAGGAGG
TGGTGGLLYGNGGNGGNVPSGAADGGAGGDARLIGNGGDGGSVGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQGFSDGG
TGGNAGMFGDGGNGGFSFFDGNGGDGGTGGTLIGNGGDGGNSVQTDGFLRGHGGDGGNAVGLIGNGGAGGAGSAGTGVFA
PGGGSGGNGGNGALLVGNGGAGGSGGPTQIPSVAVPVTGAGGTGGNGGTAGLIGNGGNGGAAGVSGDGTPGTGGNGGYAQ
LIGDGGDGGPGDSGGPGGSGGTGGTLAGQNGSPGG

Sequences:

>Translated_515_residues
MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGADEVSAAVADLFGAHAQAYQALSAQAALFHEQFVHAM
TAGAGAYAGAEAADAAALDVLNGPFQALFGRPLIGDGANGAPGQPGGPGGLLYGNGGNGGNGGIGQPGGAGGDAGLIGNG
GNGGIGGPGATGLAGGAGGVGGLLFGDGGNGGAGGLGTGPVGATGGIGGPGGAAVGLFGHGGAGGAGGLGKAGFAGGAGG
TGGTGGLLYGNGGNGGNVPSGAADGGAGGDARLIGNGGDGGSVGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQGFSDGG
TGGNAGMFGDGGNGGFSFFDGNGGDGGTGGTLIGNGGDGGNSVQTDGFLRGHGGDGGNAVGLIGNGGAGGAGSAGTGVFA
PGGGSGGNGGNGALLVGNGGAGGSGGPTQIPSVAVPVTGAGGTGGNGGTAGLIGNGGNGGAAGVSGDGTPGTGGNGGYAQ
LIGDGGDGGPGDSGGPGGSGGTGGTLAGQNGSPGG
>Mature_514_residues
SFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGADEVSAAVADLFGAHAQAYQALSAQAALFHEQFVHAMT
AGAGAYAGAEAADAAALDVLNGPFQALFGRPLIGDGANGAPGQPGGPGGLLYGNGGNGGNGGIGQPGGAGGDAGLIGNGG
NGGIGGPGATGLAGGAGGVGGLLFGDGGNGGAGGLGTGPVGATGGIGGPGGAAVGLFGHGGAGGAGGLGKAGFAGGAGGT
GGTGGLLYGNGGNGGNVPSGAADGGAGGDARLIGNGGDGGSVGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQGFSDGGT
GGNAGMFGDGGNGGFSFFDGNGGDGGTGGTLIGNGGDGGNSVQTDGFLRGHGGDGGNAVGLIGNGGAGGAGSAGTGVFAP
GGGSGGNGGNGALLVGNGGAGGSGGPTQIPSVAVPVTGAGGTGGNGGTAGLIGNGGNGGAAGVSGDGTPGTGGNGGYAQL
IGDGGDGGPGDSGGPGGSGGTGGTLAGQNGSPGG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PE family. PGRS subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PG34_MYCTU (Q50594)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   H70663
- RefSeq:   NP_336345.1
- RefSeq:   YP_177847.1
- ProteinModelPortal:   Q50594
- EnsemblBacteria:   EBMYCT00000003277
- EnsemblBacteria:   EBMYCT00000072300
- GeneID:   885753
- GeneID:   923729
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1888
- KEGG:   mtu:Rv1840c
- TIGR:   MT1888
- TubercuList:   Rv1840c
- GeneTree:   EBGT00070000031790
- HOGENOM:   HBG131001
- OMA:   TINMANV
- ProtClustDB:   CLSK799849
- InterPro:   IPR000084

Pfam domain/function: PF00934 PE

EC number: NA

Molecular weight: Translated: 43916; Mature: 43785

Theoretical pI: Translated: 3.66; Mature: 3.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f02bcd8)-; HASH(0x1e678590)-; HASH(0x1f101118)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGADEVSAAVADLFGAHAQ
CCEEEECCCEEEEEHHHHHHHHHHHHCCCHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHH
AYQALSAQAALFHEQFVHAMTAGAGAYAGAEAADAAALDVLNGPFQALFGRPLIGDGANG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCC
APGQPGGPGGLLYGNGGNGGNGGIGQPGGAGGDAGLIGNGGNGGIGGPGATGLAGGAGGV
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCC
GGLLFGDGGNGGAGGLGTGPVGATGGIGGPGGAAVGLFGHGGAGGAGGLGKAGFAGGAGG
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
TGGTGGLLYGNGGNGGNVPSGAADGGAGGDARLIGNGGDGGSVGAAPTGIGNGGNGGNGG
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
WLYGDGGSGGSTLQGFSDGGTGGNAGMFGDGGNGGFSFFDGNGGDGGTGGTLIGNGGDGG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCCCC
NSVQTDGFLRGHGGDGGNAVGLIGNGGAGGAGSAGTGVFAPGGGSGGNGGNGALLVGNGG
CCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCEEEEEECCC
AGGSGGPTQIPSVAVPVTGAGGTGGNGGTAGLIGNGGNGGAAGVSGDGTPGTGGNGGYAQ
CCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
LIGDGGDGGPGDSGGPGGSGGTGGTLAGQNGSPGG
EEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCH
>Mature Secondary Structure 
SFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGADEVSAAVADLFGAHAQ
CEEEECCCEEEEEHHHHHHHHHHHHCCCHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHH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EEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036