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The map label for this gene is cycA [H]

Identifier: 148661501

GI number: 148661501

Start: 1931304

End: 1932974

Strand: Reverse

Name: cycA [H]

Synonym: MRA_1713

Alternate gene names: 148661501

Gene position: 1932974-1931304 (Counterclockwise)

Preceding gene: 148661502

Following gene: 148661500

Centisome position: 43.73

GC content: 63.26

Gene sequence:

>1671_bases
ATGCCGGACGATATCGCGGCTGCCGACCCGACAGACACCCAGCCGCACCTGCGTCGGGACCTTGCCAACCGCCATATTCA
GTTGATCGCGATTGGAGGCGCGATCGGCACCGGCCTATTCATGGGATCTGGGCGAACGATCTCGCTCGCCGGTCCGGCGG
TCATGGTGGTCTACGGGATCATTGGGTTTTTTGTGTTTTTTGTGTTGCGCGCGATGGGCGAGCTGCTGCTGTCGAACCTG
AACTACAAGTCGTTCGTTGACTTCGCCGCCGACCTCCGGGGCCCGGCGGCGGGCTTTTTCGTGGGGTGGTCGTACTGGTT
CGCATGGGTGGTCACCGGGATCGCAGACCTCGTCGCGATCACCGGCTATGCCAGGTTTTGGTGGCCCGGCTTGCCAATCT
GGGTCCCGGCCCTGGTCACGGTCGCCCTGATTCTCGCTGTCAATTTGTTCAGCGTCCGCCACTTCGGGGAGCTGGAGTTT
TGGTTCGCATTGATCAAGGTCGCTGCCATCGTGTGCCTCATCGCCGTCGGCGCGATCCTGGTGGCAACCAACTTCGTCTC
CCCTCATGGTGTGCACGCGACCATCGAGAACCTGTGGAACGACAACGGGTTCTTCCCAACGGGTTTCCTGGGCGTGGTCA
GTGGCTTTCAGATCGCGTTTTTCGCATACATCGGTGTGGAGCTCGTTGGCACCGCCGCGGCTGAGACAGCGGACCCGCGC
CGCACCCTTCCCCGCGCGATCAATGCCGTGCCGTTGCGGGTCGCGGTGTTCTACATCGGTGCCCTGCTGGCGATCCTGGC
CGTCGTGCCGTGGCGGCAGTTCGCCAGTGGCGAGTCCCCGTTTGTGACGATGTTCTCCCTAGCCGGACTTGCCGCTGCGG
CGTCGGTCGTCAACTTCGTCGTGGTCACCGCAGCGGCCTCGTCAGCGAACTCCGGCTTCTTCTCCACCGGGCGAATGCTT
TTCGGCCTCGCCGACGAAGGCCACGCTCCGGCCGCTTTCCACCAACTCAATCGCGGCGGCGTGCCCGCACCCGCCCTGCT
GCTGACGGCTCCGCTACTGCTGACCTCCATCCCGCTGCTCTATGCCGGTCGGTCGGTGATTGGGGCGTTCACACTCGTCA
CGACGGTCTCATCCCTGCTGTTCATGTTTGTGTGGGCAATGATCATCATCAGCTACCTCGTCTACCGTCGCCGACACCCA
CAGCGTCACACCGACTCGGTGTACAAGATGCCCGGTGGCGTGGTGATGTGCTGGGCCGTGCTGGTGTTTTTCGCGTTCGT
GATCTGGACACTTACCACCGAAACCGAAACCGCAACCGCGTTGGCGTGGTTCCCGCTATGGTTCGTGCTGCTCGCCGTGG
GTTGGCTCGTCACCCAGCGCCGGCAGAGCCGCCGCAGCTTTGGTTTTCACTGCCAGGTCGTCGGGGTTCGTCAGCAGCTC
GGCCGCGGTATGGCCAGGCTTGCAATGAAAATCCACGCGCGGCCCAAACTCCGAAGTGCGGTCGTCGTCGAGCCAGTGTC
AGCAGGTGAACCAGGTGCCCGCAGGTCCGCGAAATCTGTGCGTAAGCTAGCGAGCGATGATTCGCAAAGCGCGCATTGCC
CCGTTGCGGTGGTCGGTCTGGCGGATGGCGGCCGGGATCCGCAATATCACCACGACGGGCCAGATCGGTGA

Upstream 100 bases:

>100_bases
GCGGGTCCCCGCTACGGGTTCCGGGTTACGGTGATGTCCCGGCCGCCGTTTGCCGGATAACGCGAGGCCTTCCCTACCCC
AGAACTCGAGGACGCCATAT

Downstream 100 bases:

>100_bases
TGGACGCGAAGCGGCGGCCGTCGACTATGTCCTCGCCCACGCCGGGGCCGGCAACATCGACGACGTGCTGGCCACCATCG
ACAAGTTCGCCTATGAGAAG

Product: D-serine/alanine/glycine transporter protein CycA

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGRTISLAGPAVMVVYGIIGFFVFFVLRAMGELLLSNL
NYKSFVDFAADLRGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEF
WFALIKVAAIVCLIAVGAILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIAFFAYIGVELVGTAAAETADPR
RTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPFVTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTGRML
FGLADEGHAPAAFHQLNRGGVPAPALLLTAPLLLTSIPLLYAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHP
QRHTDSVYKMPGGVVMCWAVLVFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVTQRRQSRRSFGFHCQVVGVRQQL
GRGMARLAMKIHARPKLRSAVVVEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR

Sequences:

>Translated_556_residues
MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGRTISLAGPAVMVVYGIIGFFVFFVLRAMGELLLSNL
NYKSFVDFAADLRGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEF
WFALIKVAAIVCLIAVGAILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIAFFAYIGVELVGTAAAETADPR
RTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPFVTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTGRML
FGLADEGHAPAAFHQLNRGGVPAPALLLTAPLLLTSIPLLYAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHP
QRHTDSVYKMPGGVVMCWAVLVFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVTQRRQSRRSFGFHCQVVGVRQQL
GRGMARLAMKIHARPKLRSAVVVEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR
>Mature_555_residues
PDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGRTISLAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLN
YKSFVDFAADLRGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEFW
FALIKVAAIVCLIAVGAILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIAFFAYIGVELVGTAAAETADPRR
TLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPFVTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTGRMLF
GLADEGHAPAAFHQLNRGGVPAPALLLTAPLLLTSIPLLYAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQ
RHTDSVYKMPGGVVMCWAVLVFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVTQRRQSRRSFGFHCQVVGVRQQLG
RGMARLAMKIHARPKLRSAVVVEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=345, Percent_Identity=23.768115942029, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=59.1304347826087, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=39.5196506550218, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1786302, Length=452, Percent_Identity=38.716814159292, Blast_Score=315, Evalue=6e-87,
Organism=Escherichia coli, GI1786789, Length=462, Percent_Identity=37.8787878787879, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI87081915, Length=449, Percent_Identity=38.3073496659243, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI48994972, Length=420, Percent_Identity=40.4761904761905, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI87081708, Length=474, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1788480, Length=411, Percent_Identity=35.5231143552311, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789017, Length=422, Percent_Identity=32.2274881516588, Blast_Score=218, Evalue=7e-58,
Organism=Escherichia coli, GI2367353, Length=361, Percent_Identity=25.207756232687, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=423, Percent_Identity=24.3498817966903, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=349, Percent_Identity=26.3610315186246, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=423, Percent_Identity=32.387706855792, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324061, Length=421, Percent_Identity=32.541567695962, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324924, Length=416, Percent_Identity=31.25, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=441, Percent_Identity=28.7981859410431, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=420, Percent_Identity=31.6666666666667, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=27.5184275184275, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=411, Percent_Identity=27.4939172749392, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=422, Percent_Identity=27.4881516587678, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=29.4710327455919, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324059, Length=438, Percent_Identity=31.5068493150685, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=444, Percent_Identity=25.9009009009009, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=443, Percent_Identity=25.9593679458239, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=531, Percent_Identity=24.105461393597, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321053, Length=403, Percent_Identity=28.287841191067, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=441, Percent_Identity=23.5827664399093, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=427, Percent_Identity=26.2295081967213, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=446, Percent_Identity=26.6816143497758, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=504, Percent_Identity=23.8095238095238, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 60048; Mature: 59917

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGRTISLAGPAVMVVYGI
CCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHH
IGFFVFFVLRAMGELLLSNLNYKSFVDFAADLRGPAAGFFVGWSYWFAWVVTGIADLVAI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEFWFALIKVAAIVCLIAVGAIL
HCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIAFFAYIGVELVGTAAAETADPR
HHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPFVTMFSLAGLAAAASVVNFV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VVTAAASSANSGFFSTGRMLFGLADEGHAPAAFHQLNRGGVPAPALLLTAPLLLTSIPLL
HHHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
YAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQRHTDSVYKMPGGVVMCWAV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHH
LVFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVTQRRQSRRSFGFHCQVVGVRQQL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
GRGMARLAMKIHARPKLRSAVVVEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGL
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
ADGGRDPQYHHDGPDR
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGRTISLAGPAVMVVYGI
CCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHH
IGFFVFFVLRAMGELLLSNLNYKSFVDFAADLRGPAAGFFVGWSYWFAWVVTGIADLVAI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEFWFALIKVAAIVCLIAVGAIL
HCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIAFFAYIGVELVGTAAAETADPR
HHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPFVTMFSLAGLAAAASVVNFV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VVTAAASSANSGFFSTGRMLFGLADEGHAPAAFHQLNRGGVPAPALLLTAPLLLTSIPLL
HHHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
YAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQRHTDSVYKMPGGVVMCWAV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHH
LVFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVTQRRQSRRSFGFHCQVVGVRQQL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
GRGMARLAMKIHARPKLRSAVVVEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGL
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
ADGGRDPQYHHDGPDR
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]