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The map label for this gene is 148661042

Identifier: 148661042

GI number: 148661042

Start: 1404088

End: 1404696

Strand: Reverse

Name: 148661042

Synonym: MRA_1263

Alternate gene names: NA

Gene position: 1404696-1404088 (Counterclockwise)

Preceding gene: 148661043

Following gene: 148661039

Centisome position: 31.78

GC content: 67.0

Gene sequence:

>609_bases
ATGGCGGGTACCGACTGGCTGTCCGCGCGTCGGACCGAGTTAGCCGCAGATCGGATACTCGACGCCGCCGAGCGACTCTT
TACGCAGCGTGACCCGGCGTCGATCGGCATGAACGAGATCGCCAAGGCCGCAGGCTGTTCGCGCGCAACACTGTATCGGT
ACTTCGACAGCCGCGAGGCGCTGCGAACCGCGTACGTGCACCGCGAGACCCGCCGGCTCGGCCGCGAGATCATGGTGAAG
ATCGCCGATGTCGTCGAACCTGCCGAACGGCTGCTGGTGAGCATCACCACGACGTTGCGGATGGTCCGCGACAACCCCGC
GTTGGCCGCGTGGTTTACCACCACCCGCCCACCGATCGGCGGCGAGATGGCCGGACGGTCCGAGGTGATCGCGGCCCTGG
CCGCGGCATTCCTCAACTCACTAGGTCCCGACGATCCGACCACCGTCGAACGCCGCGCCCGCTGGGTGGTCCGGATGCTC
ACATCGCTGCTGATGTTCCCCGGCCGTGACGAAGCCGACGAACGAGCGATGATCGCGGAGTTCGTCGTCCCGATCGTGAC
ACCTGCTTCTGCCGCCGCTAGGAAGGCCGGTCACCCTGGACCCGAGTGA

Upstream 100 bases:

>100_bases
CCCGGTGCCCGGACTTCGAGGTGGCCGAGTCACGCATCGTGTGGTCCGGCGGCAGTTATGTCCGGCGTCCGCTGTCGGTG
CCGTTCCGAGTGACATCCTG

Downstream 100 bases:

>100_bases
AACGGTGCAACAACCACGCCAATGGGATCGTCAGCACCAGCGTCACGAGACAAAGGTTCACCATCGAACTGGTGTAAACC
CGATACCCGAGCACGTCCAC

Product: putative transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAGCSRATLYRYFDSREALRTAYVHRETRRLGREIMVK
IADVVEPAERLLVSITTTLRMVRDNPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRML
TSLLMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE

Sequences:

>Translated_202_residues
MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAGCSRATLYRYFDSREALRTAYVHRETRRLGREIMVK
IADVVEPAERLLVSITTTLRMVRDNPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRML
TSLLMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE
>Mature_201_residues
AGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAGCSRATLYRYFDSREALRTAYVHRETRRLGREIMVKI
ADVVEPAERLLVSITTTLRMVRDNPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRMLT
SLLMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1255_MYCTU (Q11063)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   G70752
- RefSeq:   NP_215771.1
- RefSeq:   NP_335738.1
- ProteinModelPortal:   Q11063
- EnsemblBacteria:   EBMYCT00000002685
- EnsemblBacteria:   EBMYCT00000070393
- GeneID:   887068
- GeneID:   924776
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1294
- KEGG:   mtu:Rv1255c
- TIGR:   MT1294
- TubercuList:   Rv1255c
- GeneTree:   EBGT00050000014661
- HOGENOM:   HBG565182
- OMA:   FVHREAR
- ProtClustDB:   CLSK791053
- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647
- Gene3D:   G3DSA:1.10.357.10
- PRINTS:   PR00455

Pfam domain/function: PF00440 TetR_N; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 22223; Mature: 22092

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS01081 HTH_TETR_1; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAGCSRATLYRYFDSREA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHH
LRTAYVHRETRRLGREIMVKIADVVEPAERLLVSITTTLRMVRDNPALAAWFTTTRPPIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
GEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRMLTSLLMFPGRDEADERAMIAE
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FVVPIVTPASAAARKAGHPGPE
HHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
AGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAGCSRATLYRYFDSREA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHH
LRTAYVHRETRRLGREIMVKIADVVEPAERLLVSITTTLRMVRDNPALAAWFTTTRPPIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
GEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRMLTSLLMFPGRDEADERAMIAE
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FVVPIVTPASAAARKAGHPGPE
HHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036