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The map label for this gene is yisK [H]

Identifier: 148660718

GI number: 148660718

Start: 1049720

End: 1051654

Strand: Direct

Name: yisK [H]

Synonym: MRA_0947

Alternate gene names: 148660718

Gene position: 1049720-1051654 (Clockwise)

Preceding gene: 148660717

Following gene: 148660721

Centisome position: 23.75

GC content: 67.18

Gene sequence:

>1935_bases
ATGAAGTGGGTGACGTATCGAAGTGACCACGGCGAACGAACGGGAGTGCTTTCCGGTGACGCCATCTACGCGATGCCGCC
GGACGTGTCGTTGCTGGATCTGGTCGGGCGCGGCGCCGACGGTCTGCGCACGGCGGGCGAACGGGCAGTGCGCTCACCGG
CCGCGGTGGTAGCGCTCGACGAGGTTACGCTGGCGGCGCCGATTCCGCGCCCGCCGTCGATCCGGGACTCGTTGTGCTTT
CTGGACCACATGCGTAACTGCCAGGAAGCGATGGGGGGCGGCCGGGTGCTCATGGATACTTGGTACCGCATCCCGGCGTT
CTACTTCGCGTGCCCGTCAACGGTTTTGGGACCGTACGACGACGCACCCACCGCACCCGGAAGTGCGTGGCAGGACTTCG
AATTGGAGATCGCGGCGGTTATCGGAACCAGCGGCAAAGACTTGACCGTCGAGCAGGCCGAACGGTCGATCATCGGCTAT
ACCATTTTCAACGACTGGTCCGCACGGGACCTGCAGATGCTGGAGGGCCAGCTGCGCATCGGACAGGCCAAGGGCAAAGA
CAGCGGTATCACCCTGGGCCCCTATCTGGTCACACCGGATGAGCTGGAGCCCTATTGCCGGGGCGGGAAGCTAAGCTTGC
GGGTGATCGCCTTGGTCAACGGCACCGTGATCGGATCGGGGTCGACCGCACAGATGGACTGGAGCTTCGGCGAAGTCATC
GCCTATGCCTCGCGGGGGGTGACGCTGACCCCGGGTGACGTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCGA
GCACCTCAGGCCACCGGAATCATTCCCGGGCTGGCTGCACGACGGCGACGTGGTCACCCTCCAGGTCGAAGGGCTGGGCG
AGACGAGGCAGACCGTCCGGACGAGCGGCACTCCTTTTCCGTTGGCTCTTCGGCCGAATCCGGACGCCGAACCCGACCGG
CGCGGGGTCAACCCGGCACCGACGCGGGTGCCGTTTACCCGCGGGCTGCACGAAGTCGCCGACCGGGTATGGGCGTGGAC
GCTGCCCGACGGGGGATACGGCTTCAGCAACGCCGGGCTGGTCGCCGGGGACGGCGCGTCGCTGCTCGTGGATACCCTGT
TCGACCTGGCACTGACACGCGAGATGTTGGCCGCGATGAAGCCGGTCACCGAGCGGGCGCCCATCACCGACGCCCTGATC
ACGCACTCCAACGGCGACCACACGCACGGCACTCAACTGTTGGACCGCTCAGTGCGCATCATCGCCGCCAAGGGCACCTC
CGAGGAGATCGAGCATGGCCCGGCACCGGAGATGCTAGCCCGGATCCAAACCGCCGACCTGGGCCCCGTTGCGACGCGGT
ATCTGCGTGATCGCTTCGGTCACTTTGACTTCAGCGGCATCAAGCTGCGCAACGCCGACCTGACGTTCGACCGCGACCTG
GCCATCGAGCTCGGCGGCCGGCGAGTCGACCTGCTCAACCTCGGTCCCGCGCACACCACCGCCGACTCGGTCGTGCACGT
GGCCGACGCCGGTGTGCTGTTCGCCGGGGATCTGCTGTTCATCGGTTGCACCCCGATTGTGTGGGCGGGCCCGATCGCCA
ACTGGGTGGCGGCCTGCGACGCGATGATCGCGCTGGACGCGCCCACGGTGGTGCCTGGGCATGGTCCGGTCACCGGCCCG
GACGGGATCCGTGCCGTCCGTGGCTATCTGGCGCACATCGCCGAACAGGCCGAGGCGGCCTACCGCAAGGGGCTATCGTT
GCCCGAGGCCGTCGAGACCATCGACCTGGGCGAGTACGCGAGCTGGCTGGACTCCGAACGGGTAGTGGTCAACGTCTACC
AGCGTTACCGCGAATTGGATCCCGACACCCCGCGCCAGGACTTGCTGGCGTTGCTGGTGATGCAGGCCGAATGGGCGGCG
CGCCACTGTACGTAG

Upstream 100 bases:

>100_bases
CAGAGGTGCGCTACAGCGAGTGGACTCCGGAGGGCCGGCTGCGTCAATCAAGCTGGCGTGGGCTGCGGCCGGACAAGAAA
CCCAGTGAGGTGGTGCGCGA

Downstream 100 bases:

>100_bases
CCACTCGGGCGCGTTTGTCACGGGAATCTGCGGACCGGCGGGCGCATGGTTTGCCTGTCCACGAGCGACAAAGCCAGCGC
GCCAAGGATTCCCGATGGCA

Product: fumarylacetoacetate hydrolase family/metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAVRSPAAVVALDEVTLAAPIPRPPSIRDSLCF
LDHMRNCQEAMGGGRVLMDTWYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGY
TIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVI
AYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHDGDVVTLQVEGLGETRQTVRTSGTPFPLALRPNPDAEPDR
RGVNPAPTRVPFTRGLHEVADRVWAWTLPDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDALI
THSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDRFGHFDFSGIKLRNADLTFDRDL
AIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVTGP
DGIRAVRGYLAHIAEQAEAAYRKGLSLPEAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWAA
RHCT

Sequences:

>Translated_644_residues
MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAVRSPAAVVALDEVTLAAPIPRPPSIRDSLCF
LDHMRNCQEAMGGGRVLMDTWYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGY
TIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVI
AYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHDGDVVTLQVEGLGETRQTVRTSGTPFPLALRPNPDAEPDR
RGVNPAPTRVPFTRGLHEVADRVWAWTLPDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDALI
THSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDRFGHFDFSGIKLRNADLTFDRDL
AIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVTGP
DGIRAVRGYLAHIAEQAEAAYRKGLSLPEAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWAA
RHCT
>Mature_644_residues
MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAVRSPAAVVALDEVTLAAPIPRPPSIRDSLCF
LDHMRNCQEAMGGGRVLMDTWYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGY
TIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVI
AYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHDGDVVTLQVEGLGETRQTVRTSGTPFPLALRPNPDAEPDR
RGVNPAPTRVPFTRGLHEVADRVWAWTLPDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDALI
THSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDRFGHFDFSGIKLRNADLTFDRDL
AIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVTGP
DGIRAVRGYLAHIAEQAEAAYRKGLSLPEAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWAA
RHCT

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=304, Percent_Identity=31.25, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI40786394, Length=304, Percent_Identity=30.2631578947368, Blast_Score=106, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28572127, Length=307, Percent_Identity=28.6644951140065, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 69354; Mature: 69354

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAVRSPAAVVALD
CCEEEEECCCCCCCCEECCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEE
EVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDTWYRIPAFYFACPSTVLGPYD
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCHHCCCCC
DAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGYTIFNDWSARDLQMLEGQLRI
CCCCCCCCCCCCCEEEEEEEECCCCCCEEHHHHCCCEEEEEEECCCCCHHHHHHHCHHEE
GQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVI
CCCCCCCCCEEECCEEECCCCCCHHHCCCCEEEEEEEEECCEEEECCCCEEECCCHHHHH
AYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHDGDVVTLQVEGLGETRQTVR
HHHCCCCEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
TSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVADRVWAWTLPDGGYGFSNAGL
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCE
VAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDALITHSNGDHTHGTQLLDRSVRI
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCCCCHHHHHHCCCEEE
IAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDRFGHFDFSGIKLRNADLTFDRDL
EEECCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCE
AIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACD
EEEECCCEEEEEECCCCCCCHHCEEEEECCCEEEECCEEEEECCCCEECCHHHHHHHHHH
AMIALDAPTVVPGHGPVTGPDGIRAVRGYLAHIAEQAEAAYRKGLSLPEAVETIDLGEYA
HHEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHH
SWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWAARHCT
HHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAVRSPAAVVALD
CCEEEEECCCCCCCCEECCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEE
EVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDTWYRIPAFYFACPSTVLGPYD
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCHHCCCCC
DAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGYTIFNDWSARDLQMLEGQLRI
CCCCCCCCCCCCCEEEEEEEECCCCCCEEHHHHCCCEEEEEEECCCCCHHHHHHHCHHEE
GQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVI
CCCCCCCCCEEECCEEECCCCCCHHHCCCCEEEEEEEEECCEEEECCCCEEECCCHHHHH
AYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHDGDVVTLQVEGLGETRQTVR
HHHCCCCEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
TSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVADRVWAWTLPDGGYGFSNAGL
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCE
VAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDALITHSNGDHTHGTQLLDRSVRI
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCCCCHHHHHHCCCEEE
IAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDRFGHFDFSGIKLRNADLTFDRDL
EEECCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCE
AIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACD
EEEECCCEEEEEECCCCCCCHHCEEEEECCCEEEECCEEEEECCCCEECCHHHHHHHHHH
AMIALDAPTVVPGHGPVTGPDGIRAVRGYLAHIAEQAEAAYRKGLSLPEAVETIDLGEYA
HHEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHH
SWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWAARHCT
HHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]