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The map label for this gene is 148660717

Identifier: 148660717

GI number: 148660717

Start: 1047444

End: 1049723

Strand: Direct

Name: 148660717

Synonym: MRA_0946

Alternate gene names: NA

Gene position: 1047444-1049723 (Clockwise)

Preceding gene: 148660715

Following gene: 148660718

Centisome position: 23.7

GC content: 65.57

Gene sequence:

>2280_bases
ATGGGTTCGGCGTCGGAGCAACGGGTGACGCTGACCAACGCCGACAAGGTGCTCTATCCCGCCACCGGGACCACAAAGTC
CGATATCTTCGACTACTACGCCGGTGTTGCCGAAGTCATGCTCGGCCACATCGCGGGACGGCCGGCGACGCGCAAGCGCT
GGCCTAACGGCGTCGACCAACCCGCGTTCTTCGAAAAGCAGTTGGCGTTGTCGGCGCCGCCTTGGCTGTCACGTGCAACG
GTGGCGCACCGGTCCGGGACGACGACCTATCCGATCATCGATAGCGCAACCGGGCTGGCCTGGATCGCCCAACAGGCGGC
GCTGGAGGTGCACGTGCCGCAGTGGCGGTTTGTCGCCGAGCCCGGATCAGGTGAGTTAAATCCGGGCCCGGCAACGCGTT
TGGTGTTCGACCTGGACCCGGGCGAAGGCGTGATGATGGCCCAGCTGGCCGAGGTGGCGCGCGCGGTTCGTGATCTTCTC
GCCGATATCGGGTTGGTCACCTTCCCGGTCACCAGCGGCAGCAAGGGATTGCATCTGTACACACCGCTGGATGAGCCGGT
GAGCAGCAGGGGAGCCACGGTGTTGGCCAAGCGCGTCGCGCAGCGATTGGAGCAGGCGATGCCCGCGTTGGTCACCTCGA
CCATGACCAAAAGCCTGCGGGCCGGGAAGGTGTTTGTGGACTGGAGCCAGAACAGCGGCTCGAAGACCACCATCGCGCCG
TACTCACTACGTGGCCGGACGCATCCGACCGTCGCGGCGCCACGCACCTGGGCGGAGCTCGACGACCCCGCACTGCGTCA
GCTCTCCTACGACGAGGTGCTGACCCGGATTGCCCGCGACGGCGATCTGCTCGAGCGGCTGGATGCCGACGCTCCGGTAG
CGGACCGGTTGACCCGATACCGCCGCATGCGCGACGCATCGAAAACTCCCGAGCCGATTCCCACGGCGAAACCCGTTACC
GGAGACGGCAATACGTTCGTCATCCAGGAGCATCACGCGCGTCGGCCGCACTACGATTTCCGGCTGGAATGCGACGGCGT
GCTGGTCTCGTGGGCGGTACCGAAAAACCTGCCCGACAACACATCGGTTAACCATCTAGCGATACACACCGAGGACCACC
CGCTGGAATACGCCACGTTCGAGGGCGCGATTCCCAGCGGGGAGTACGGCGCCGGCAAGGTGATCATCTGGGACTCCGGC
ACTTACGACACCGAGAAGTTCCACGATGACCCGCACACGGGGGAGGTCATCGTGAATCTGCACGGCGGCCGGATCTCTGG
GCGTTATGCGCTGATTCGGACCAACGGCGATCGGTGGCTGGCGCACCGCCTAAAGAATCAGAAAGACCAGAAGGTGTTCG
AGTTCGACAATCTGGCCCCAATGCTTGCCACGCACGGCACGGTGGCCGGTCTAAAGGCCAGCCAGTGGGCGTTCGAAGGC
AAGTGGGACGGCTACCGGTTGCTGGTTGAGGCTGACCACGGCGCCGTGCGGCTGCGGTCCCGCAGCGGGCGCGATGTCAC
CGCCGAGTATCCGCAATTGCGGGCATTGGCGGAGGATCTCGCCGATCACCACGTGGTGCTGGACGGCGAGGCCGTCGTAC
TTGACTCCTCTGGTGTGCCCAGCTTCAGCCAGATGCAGAATCGGGGCCGCGACACCCGTGTCGAGTTCTGGGCGTTCGAC
CTGCTCTACCTCGACGGCCGCGCGCTGCTAGGCACCCGCTACCAAGACCGGCGTAAGCTGCTCGAAACCCTAGCTAACGC
AACCAGTCTCACCGTTCCCGAGCTGCTGCCCGGTGACGGCGCCCAAGCGTTTGCGTGCTCGCGCAAGCACGGCTGGGAGG
GCGTGATCGCCAAGAGGCGTGACTCGCGCTATCAGCCGGGCCGGCGCTGCGCGTCGTGGGTCAAGGACAAGCACTGGAAC
ACCCAGGAAGTCGTCATTGGTGGCTGGCGCGCCGGGGAAGGCGGGCGCAGCAGTGGCGTCGGGTCGCTGCTCATGGGCAT
CCCCGGTCCAGGTGGGCTGCAGTTCGCCGGGCGGGTCGGTACCGGCCTCAGCGAACGCGAACTGGCCAACCTCAAGGAGA
TGCTGGCGCCGCTGCATACCGACGAGTCCCCCTTCGACGTACCACTGCCCGCGCGTGACGCCAAGGGCATCACATATGTC
AAGCCGGCGCTGGTTGCAGAGGTGCGCTACAGCGAGTGGACTCCGGAGGGCCGGCTGCGTCAATCAAGCTGGCGTGGGCT
GCGGCCGGACAAGAAACCCAGTGAGGTGGTGCGCGAATGA

Upstream 100 bases:

>100_bases
TTGATTGTCCGCGAGCGGAACGTCACGGCGAAATTCCACGCGATATTTGACCGTGACGTTACGCTCGCGACTTGTGTGAC
CGACAGGCTACGTTGAAAGC

Downstream 100 bases:

>100_bases
AGTGGGTGACGTATCGAAGTGACCACGGCGAACGAACGGGAGTGCTTTCCGGTGACGCCATCTACGCGATGCCGCCGGAC
GTGTCGTTGCTGGATCTGGT

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRAT
VAHRSGTTTYPIIDSATGLAWIAQQAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLL
ADIGLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAP
YSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDGDLLERLDADAPVADRLTRYRRMRDASKTPEPIPTAKPVT
GDGNTFVIQEHHARRPHYDFRLECDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDSG
TYDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNLAPMLATHGTVAGLKASQWAFEG
KWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALAEDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFD
LLYLDGRALLGTRYQDRRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDKHWN
TQEVVIGGWRAGEGGRSSGVGSLLMGIPGPGGLQFAGRVGTGLSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYV
KPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKPSEVVRE

Sequences:

>Translated_759_residues
MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRAT
VAHRSGTTTYPIIDSATGLAWIAQQAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLL
ADIGLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAP
YSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDGDLLERLDADAPVADRLTRYRRMRDASKTPEPIPTAKPVT
GDGNTFVIQEHHARRPHYDFRLECDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDSG
TYDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNLAPMLATHGTVAGLKASQWAFEG
KWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALAEDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFD
LLYLDGRALLGTRYQDRRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDKHWN
TQEVVIGGWRAGEGGRSSGVGSLLMGIPGPGGLQFAGRVGTGLSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYV
KPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKPSEVVRE
>Mature_758_residues
GSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRATV
AHRSGTTTYPIIDSATGLAWIAQQAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLLA
DIGLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAPY
SLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDGDLLERLDADAPVADRLTRYRRMRDASKTPEPIPTAKPVTG
DGNTFVIQEHHARRPHYDFRLECDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDSGT
YDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNLAPMLATHGTVAGLKASQWAFEGK
WDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALAEDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFDL
LYLDGRALLGTRYQDRRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDKHWNT
QEVVIGGWRAGEGGRSSGVGSLLMGIPGPGGLQFAGRVGTGLSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYVK
PALVAEVRYSEWTPEGRLRQSSWRGLRPDKKPSEVVRE

Specific function: Unknown

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family

Homologues:

Organism=Homo sapiens, GI4557719, Length=281, Percent_Identity=29.5373665480427, Blast_Score=74, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320038, Length=283, Percent_Identity=26.5017667844523, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y938_MYCTU (P71571)

Other databases:

- EMBL:   BX842575
- EMBL:   AE000516
- PIR:   B70585
- RefSeq:   NP_215453.1
- RefSeq:   NP_335398.1
- PDB:   1VS0
- PDB:   2IRU
- PDB:   2IRX
- PDB:   2IRY
- PDB:   2R9L
- PDBsum:   1VS0
- PDBsum:   2IRU
- PDBsum:   2IRX
- PDBsum:   2IRY
- PDBsum:   2R9L
- ProteinModelPortal:   P71571
- EnsemblBacteria:   EBMYCT00000001862
- EnsemblBacteria:   EBMYCT00000072359
- GeneID:   885561
- GeneID:   926354
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0965
- KEGG:   mtu:Rv0938
- TIGR:   MT0965
- TubercuList:   Rv0938
- GeneTree:   EBGT00050000016312
- HOGENOM:   HBG547947
- OMA:   VDWSQNN
- ProtClustDB:   PRK09632
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR014146
- InterPro:   IPR002755
- InterPro:   IPR014144
- InterPro:   IPR014145
- InterPro:   IPR012340
- InterPro:   IPR016027
- Gene3D:   G3DSA:2.40.50.140
- TIGRFAMs:   TIGR02777
- TIGRFAMs:   TIGR02778
- TIGRFAMs:   TIGR02779

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF01896 DNA_primase_S; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 83573; Mature: 83442

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS50160 DNA_LIGASE_A3

Important sites: ACT_SITE 481-481

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPNGVDQ
CCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
PAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWIAQQAALEVHVPQWRFVAE
CHHHHHHHHCCCCCCCHHHHHHCCCCCEEECEECCCCHHHHHHHHHEEEEECCCEEEEEC
PGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLLADIGLVTFPVTSGSKGLHLY
CCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
TPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAP
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEE
YSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDGDLLERLDADAPVADRLTRY
EEECCCCCCCCCCCCCHHHCCCHHHHHCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHH
RRMRDASKTPEPIPTAKPVTGDGNTFVIQEHHARRPHYDFRLECDGVLVSWAVPKNLPDN
HHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCEEEEEECCCCCCCC
TSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDSGTYDTEKFHDDPHTGEVIVNL
CCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHCCCCCCCCEEEEEE
HGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNLAPMLATHGTVAGLKASQWAFEG
ECCEEECEEEEEEECCCHHHHHHHCCCCCCCHHHHCCCCHHHHCCCCCCCCCCCCCEECC
KWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALAEDLADHHVVLDGEAVVLDSSGVP
CCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCCC
SFSQMQNRGRDTRVEFWAFDLLYLDGRALLGTRYQDRRKLLETLANATSLTVPELLPGDG
CHHHHHHCCCCCEEEEEEEEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
AQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDKHWNTQEVVIGGWRAGEGGRSSGV
CCCEEECCCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
GSLLMGIPGPGGLQFAGRVGTGLSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYV
CEEEEECCCCCCCEECCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
KPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKPSEVVRE
CHHHHHEEHHCCCCCCCCCCHHHCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
GSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPNGVDQ
CCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
PAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWIAQQAALEVHVPQWRFVAE
CHHHHHHHHCCCCCCCHHHHHHCCCCCEEECEECCCCHHHHHHHHHEEEEECCCEEEEEC
PGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLLADIGLVTFPVTSGSKGLHLY
CCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
TPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAP
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEE
YSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDGDLLERLDADAPVADRLTRY
EEECCCCCCCCCCCCCHHHCCCHHHHHCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHH
RRMRDASKTPEPIPTAKPVTGDGNTFVIQEHHARRPHYDFRLECDGVLVSWAVPKNLPDN
HHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCEEEEEECCCCCCCC
TSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDSGTYDTEKFHDDPHTGEVIVNL
CCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHCCCCCCCCEEEEEE
HGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNLAPMLATHGTVAGLKASQWAFEG
ECCEEECEEEEEEECCCHHHHHHHCCCCCCCHHHHCCCCHHHHCCCCCCCCCCCCCEECC
KWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALAEDLADHHVVLDGEAVVLDSSGVP
CCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEECCCCC
SFSQMQNRGRDTRVEFWAFDLLYLDGRALLGTRYQDRRKLLETLANATSLTVPELLPGDG
CHHHHHHCCCCCEEEEEEEEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
AQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDKHWNTQEVVIGGWRAGEGGRSSGV
CCCEEECCCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
GSLLMGIPGPGGLQFAGRVGTGLSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYV
CEEEEECCCCCCCEECCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
KPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKPSEVVRE
CHHHHHEEHHCCCCCCCCCCHHHCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036