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The map label for this gene is pbp [H]

Identifier: 148660685

GI number: 148660685

Start: 1011354

End: 1013042

Strand: Direct

Name: pbp [H]

Synonym: MRA_0914

Alternate gene names: 148660685

Gene position: 1011354-1013042 (Clockwise)

Preceding gene: 148660684

Following gene: 148660686

Centisome position: 22.88

GC content: 63.65

Gene sequence:

>1689_bases
ATGGTGGCGGCTGTAATTCCCCGCAGCGCCCGGCTAATGGTGCTAGGGGGCGAGCCGAGGCGATCAAACCACCGAGTGTT
CCGGCCGCGTTGGCTACTATCTGCGGCCATGACCAAACGAGCGGCAACGGCCGCCATGGTGATGTTGCTGACGTTAACGG
GTTGCGGATCCACGCACCAGGCACTTGGCCCGCCGTCCGGGTTGCCCGATGCCTCTCCCAATGAGAGGTCAGCGATACAG
ATCCCCGCTGGCCGCATCGACGATGCCGTGGCAAAGGTCGACGGCCTGGTCGGCGAGCTGATGCAGAATACCGGCATACC
CGGAATGGCAGTGGCGATAGTCCATGGCGGAAAGACGTTGTATGCCAAAGGGTTCGGTGTCAGAGACGTGGGCAAAGGTG
GTGGTCCGGACAACAAGGTGGACGCCGACACCGTCTTTCAGTTGGCGTCGGTGTCCAAATCGGTCGGCGCCACGGTGGTG
GCGCATGCGGTAACCGACAACGTCGTGACCTGGGATACGCCCGTCGTATCGAAGCTGCCGTGGTTTGCCCTTCGCGATCC
CTACGTCACCGGCCAGGTAACCATTGCTGACCTCTACTCGCATCGCTCCGGCCTGCCCGACCATGCGGGCGATCTGTTGG
AGGATTTGGGTTATGACCGTCGACAGGTACTGCAGCGGCTGAAATACCTGCCGCTGGCACCGTTTCGAATCAGCTATGCC
TACACCAACTTTGGTGTGACCGCGGCGGCCGAAGCGGTCGCGGCCGCGGCCGGCCAGTCCTGGGAGGACCTGTCCGACGA
GGTGCTCTACCGCCCGTTGGGGATGGGGTCTACGAGTTCCCGGTTCACCGACTTTCTGGCCAGGCCCAACCATGCGGTCA
ACCACGTCAAGGTCGCAGACCGATGGGAGGCGCGCTACCAGCGCGATCCCGACGCCCAATCACCTGCGGGCGGGGTGAGT
TCGTCTCTTAACGACATGACGCACTGGCTGGCCATGGTGCTGGCCGACGGCGTGTACAACGGCCGTCGGATCACGTCGCC
GGAGGCCCTGCTCCCCGTCTACACGCCGCAGGTGATCTCTCGACACCCGGTGTCACCGAGAGCGCGGGCCAGCTTCTATG
GCTACGGATTCAACGTGGGGGTAACCTCTTCGGGACGCACCGAGTACAGCCATTCCGGCGCCTTCGGGCTGGGTGCCGCG
GCGAATTTCGTGGTGCTGCCCTCCGAAGACCTGGCCATCATCGCGCTGACCAACGCCGGGCCCATCGGCGTGCCGGAGAC
GCTGACCGCCGAATTCATGGACTTGGTGCAGTACGGCCAGGTACGCGAGGACTGGGCGGCCCTGTACAAGAAGGCATTTG
CCCCGCTGAACGAGCTCGCGGGCTCGCTGGTCGGCAAGCAATCCCCGGCCAACCCAGCGCCGAGCAGACCGCTGAACGAC
TACGTCGGCGTGTACGCCAACGACTACTGGGGGCCCGCCACCGTGACCTACCACGACGGCCAACTGCGCCTGTCGCTGGG
GCCGAAGAACCAGACGTTCGATTTGACGCACTGGGACGGCGACACTTTCACGTTCACGTTGTCGACCGAAAACGCATTGC
CCGGATCGATTTCCAAGGCCACCTTCGCCGGCGACACGTTAAACCTGGAATACTACGACGCCGACAAGCTGGGAACGTTT
ACCCGATGA

Upstream 100 bases:

>100_bases
TCGAGCGGCTGCTCGCGGCGGCTGAACCCGAGCACGTCACGGTAGCCGTGCCGCTACCCGGTCAGCGGGTCGACCCGACC
GGGCCCATGAGATTGCACCC

Downstream 100 bases:

>100_bases
CCCGTTCGGCTTCGGCGACAGCCGGTTTGACCGATGCCGAAGTGGCGCAACGGGTCGCCGAAGGCAAGAGCAACGATATC
CCGGAACGGGTCACCCGCAC

Product: penicillin-binding protein 4

Products: NA

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MVAAVIPRSARLMVLGGEPRRSNHRVFRPRWLLSAAMTKRAATAAMVMLLTLTGCGSTHQALGPPSGLPDASPNERSAIQ
IPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHGGKTLYAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVV
AHAVTDNVVTWDTPVVSKLPWFALRDPYVTGQVTIADLYSHRSGLPDHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYA
YTNFGVTAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEARYQRDPDAQSPAGGVS
SSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYTPQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLGAA
ANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND
YVGVYANDYWGPATVTYHDGQLRLSLGPKNQTFDLTHWDGDTFTFTLSTENALPGSISKATFAGDTLNLEYYDADKLGTF
TR

Sequences:

>Translated_562_residues
MVAAVIPRSARLMVLGGEPRRSNHRVFRPRWLLSAAMTKRAATAAMVMLLTLTGCGSTHQALGPPSGLPDASPNERSAIQ
IPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHGGKTLYAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVV
AHAVTDNVVTWDTPVVSKLPWFALRDPYVTGQVTIADLYSHRSGLPDHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYA
YTNFGVTAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEARYQRDPDAQSPAGGVS
SSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYTPQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLGAA
ANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND
YVGVYANDYWGPATVTYHDGQLRLSLGPKNQTFDLTHWDGDTFTFTLSTENALPGSISKATFAGDTLNLEYYDADKLGTF
TR
>Mature_562_residues
MVAAVIPRSARLMVLGGEPRRSNHRVFRPRWLLSAAMTKRAATAAMVMLLTLTGCGSTHQALGPPSGLPDASPNERSAIQ
IPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHGGKTLYAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVV
AHAVTDNVVTWDTPVVSKLPWFALRDPYVTGQVTIADLYSHRSGLPDHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYA
YTNFGVTAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEARYQRDPDAQSPAGGVS
SSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYTPQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLGAA
ANFVVLPSEDLAIIALTNAGPIGVPETLTAEFMDLVQYGQVREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND
YVGVYANDYWGPATVTYHDGQLRLSLGPKNQTFDLTHWDGDTFTFTLSTENALPGSISKATFAGDTLNLEYYDADKLGTF
TR

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1786574, Length=354, Percent_Identity=22.5988700564972, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=360, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 60259; Mature: 60259

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAAVIPRSARLMVLGGEPRRSNHRVFRPRWLLSAAMTKRAATAAMVMLLTLTGCGSTHQ
CEEEECCCCCEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ALGPPSGLPDASPNERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHGGKTL
CCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEE
YAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVVAHAVTDNVVTWDTPVVSKLP
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEHHHCCCEEECCCCHHHHCC
WFALRDPYVTGQVTIADLYSHRSGLPDHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYA
CEEECCCCCCCEEEHEEHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEE
YTNFGVTAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVAD
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEHH
RWEARYQRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYTPQVIS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCHHHHH
RHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLGAAANFVVLPSEDLAIIALTNAG
CCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCC
PIGVPETLTAEFMDLVQYGQVREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCH
YVGVYANDYWGPATVTYHDGQLRLSLGPKNQTFDLTHWDGDTFTFTLSTENALPGSISKA
HHEEEECCCCCCEEEEEECCEEEEEECCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCE
TFAGDTLNLEYYDADKLGTFTR
EECCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MVAAVIPRSARLMVLGGEPRRSNHRVFRPRWLLSAAMTKRAATAAMVMLLTLTGCGSTHQ
CEEEECCCCCEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ALGPPSGLPDASPNERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHGGKTL
CCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEE
YAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVVAHAVTDNVVTWDTPVVSKLP
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEHHHCCCEEECCCCHHHHCC
WFALRDPYVTGQVTIADLYSHRSGLPDHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYA
CEEECCCCCCCEEEHEEHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEE
YTNFGVTAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVAD
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEHH
RWEARYQRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYTPQVIS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCHHHHH
RHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLGAAANFVVLPSEDLAIIALTNAG
CCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCC
PIGVPETLTAEFMDLVQYGQVREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCH
YVGVYANDYWGPATVTYHDGQLRLSLGPKNQTFDLTHWDGDTFTFTLSTENALPGSISKA
HHEEEECCCCCCEEEEEECCEEEEEECCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCE
TFAGDTLNLEYYDADKLGTFTR
EECCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]