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The map label for this gene is udgA [H]

Identifier: 148660088

GI number: 148660088

Start: 390622

End: 391953

Strand: Direct

Name: udgA [H]

Synonym: MRA_0331

Alternate gene names: 148660088

Gene position: 390622-391953 (Clockwise)

Preceding gene: 148660087

Following gene: 148660090

Centisome position: 8.84

GC content: 64.94

Gene sequence:

>1332_bases
GTGCGATGCAGCGTCTTCGGCACTGGGTATCTGGGTGCCACCCACGCCGTCGGTATGGCGCAACTGGGACACGAGGTCGT
CGGGGTCGATATCGATCCCGGTAAGGTCGCCAAGCTCGCCGGGGGTGACATTCCGTTCTACGAACCCGGCCTGCGAAAGC
TGTTGACTGATAACCTGGCTGCCGGCCGCTTGCGGTTCACCACCGACTACGACATGGCGGCCGATTTCGCCGACGTGCAT
TTCCTGGGGGTCGGCACGCCGCAAAAGATAGGCGAATATGGCGCCGACCTGCGGCATGTCCACGCCGTCATCGATGCGCT
GGTGCCGCGTCTGGTCAGGGCGTCGATTCTGGTCGGCAAGTCGACAGTCCCAGTGGGCACCGCAGCCGAACTGGGACATC
GGGCCGGTGCACTGGCACCCCGGGGAGTCGACGTGGAAATTGCCTGGAATCCGGAATTCCTGCGCGAGGGCTTCGCGGTG
CACGACACCCTCAACCCCGACCGTATCGTCCTTGGGGTACAAGATGATTCGACGCGCGCCGAGGTAGCCGTCCGCGAGCT
GTACGCGCCGCTGCTGGCAGCGGGCGTGCCGTTTCTGGTGACCGATCTGCAGACCGCGGAGTTGGTCAAGGTATCCGCCA
ATGCCTTTCTGGCGACCAAGATTTCGTTTATCAATGCGATCTCCGAAGTGTGCGAGGCGGCGGGTGCCGACGTTAGCCAG
CTGGCCGATGCGCTCGGATACGACCCGCGGATCGGACGCCAATGCCTCAACGCGGGCTTGGGTTTCGGCGGCGGCTGCTT
GCCCAAGGACATCCGCGCTTTCATGGCCCGCGCCGGCGAACTGGGAGCCGACCAGGCGTTGACGTTCCTGCGTGAAGTGG
ACAGCATCAACATGCGCCGGCGCACCAAGATGGTGGAACTGGCCACCACCGCATGCGGTGGCTCGTTGCTGGGCGCCAAT
ATTGCGGTGCTCGGCGCGGCGTTCAAACCCGAATCCGATGACGTGCGCGATTCGCCCGCCCTCAATGTGGCGGGCCAGCT
GCAGCTCAACGGCGCCACGGTCCACGTGTACGATCCAAAGGCCTTGGACAACGCCCACCGACTGTTCCCTACCTTGAACT
ATGCGGTTTCGGTTGCGGAGGCCTGCGAGCGCGCGGACGCCGTGTTGGTGCTTACCGAATGGCGGGAGTTCATCGATCTC
GAACCCGCTGATCTAGCCAACCGGGTGCGGGCCCGGGTGATCGTGGACGGCCGCAACTGCCTCGACGTGACCCGCTGGCG
GCGGGCAGGCTGGCGGGTGTTCCGGCTGGGAGTGCCGCGATTAGGGCACTGA

Upstream 100 bases:

>100_bases
GGCGCGGCTAGGCCTGTCGCGGGTAGCTGTCACCTGCCGTTTGCCTGGTGCTCAGCGCCGCGATGCGGTTCGCTCATCGC
AGCCACCTACACACAGTGGT

Downstream 100 bases:

>100_bases
CCGGCGCAGCCAGCGCAAGTACTCTCGGTCACCGAGCAGTTCCAGACGACGCCACAGCACGGGGTTGTCGGCGGACTGGG
TGAAATGGCAGCCGATAGCG

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVH
FLGVGTPQKIGEYGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAV
HDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ
LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRTKMVELATTACGGSLLGAN
IAVLGAAFKPESDDVRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFIDL
EPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH

Sequences:

>Translated_443_residues
MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVH
FLGVGTPQKIGEYGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAV
HDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ
LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRTKMVELATTACGGSLLGAN
IAVLGAAFKPESDDVRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFIDL
EPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH
>Mature_443_residues
MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVH
FLGVGTPQKIGEYGADLRHVHAVIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAV
HDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ
LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRTKMVELATTACGGSLLGAN
IAVLGAAFKPESDDVRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFIDL
EPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=444, Percent_Identity=32.4324324324324, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI296040438, Length=346, Percent_Identity=33.5260115606936, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI296040443, Length=297, Percent_Identity=34.6801346801347, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=27.8236914600551, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI48994968, Length=415, Percent_Identity=27.9518072289157, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=458, Percent_Identity=34.9344978165939, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17136908, Length=464, Percent_Identity=32.5431034482759, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47363; Mature: 47363

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00059 ADH_ZINC ; PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLA
CEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHCCCC
AGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHAVIDALVPRLVRASILVGK
CCEEEEECCCCHHCCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
STVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRA
CCCCCCCHHHHHHHCCCCCCCCCEEEEEECHHHHHCCCEEECCCCCCEEEEEECCCCHHH
EVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ
HHHHHHHHHHHHHCCCCCEEECCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHH
LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRR
HHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHH
RTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNVAGQLQLNGATVHVYDPK
HHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCH
ALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNC
HHCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHCCCHHHHHHHCEEEEEECCCCH
LDVTRWRRAGWRVFRLGVPRLGH
HHHHHHHHCCCEEEEECCCCCCC
>Mature Secondary Structure
MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDIPFYEPGLRKLLTDNLA
CEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHCCCC
AGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHAVIDALVPRLVRASILVGK
CCEEEEECCCCHHCCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
STVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRA
CCCCCCCHHHHHHHCCCCCCCCCEEEEEECHHHHHCCCEEECCCCCCEEEEEECCCCHHH
EVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSQ
HHHHHHHHHHHHHCCCCCEEECCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHH
LADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRR
HHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHH
RTKMVELATTACGGSLLGANIAVLGAAFKPESDDVRDSPALNVAGQLQLNGATVHVYDPK
HHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCH
ALDNAHRLFPTLNYAVSVAEACERADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNC
HHCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHCCCHHHHHHHCEEEEEECCCCH
LDVTRWRRAGWRVFRLGVPRLGH
HHHHHHHHCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]