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The map label for this gene is thiC [H]

Identifier: 148654069

GI number: 148654069

Start: 2834837

End: 2836837

Strand: Direct

Name: thiC [H]

Synonym: PsycPRwf_2272

Alternate gene names: 148654069

Gene position: 2834837-2836837 (Clockwise)

Preceding gene: 148654068

Following gene: 148654072

Centisome position: 95.16

GC content: 48.63

Gene sequence:

>2001_bases
ATGAGTAATGAACAACACACCATTAAGACGCCAGCGCACCGTAATGTAAAGGATGAGCGCTTCGATGAAGAGGCTCGCGA
CTTAACCCGCAGCCTGCCGGCGTCAAGAAAAATATATATCGAGGGCTCTCGTCCTGATATTCAAGTGCCGATGCGTGAAA
TCACTTTAACCGATACGCCCACTGGCGGCTTTGGCCTAGAAAATGGGGAAAAAAATCCCCCGTTTTATGTGTATGACACC
TCGGGTGTGTATACCGACCCGAGTGTCGATATTGATTTGACCAAAGGCTTACCAAAGCTACGTGAAAAATGGATTGAAGA
GCGTGGCGATACCGAAGTTTTAGACGGCTTATCAAGCAACTATGGTCAAGAGCGTGCGCGTGATATCAAAACCGCCAACA
TCCGTTTTGCTCATATTGATAAACCTCGCCGTGCCAAAGCTGGCAAAAATGTCACTCAAATGCATTATGCCCGCCAAGGT
ATTATCACGCCTGAGATGGAATACATCGCCATCCGTGAGACCCAAAAGCAGCATGAATTAACCGATATGCGCCAACATGC
CGGCGAGACCTTTGGCGCTAATACCCCCAAAATCATTACCCCTGAATTTGTACGTGCTGAAGTGGCCGCTGGACGCGCTA
TTATCCCCAATAATATTAATCACCCAGAGTCTGAGCCGATGATTATCGGGCGCAACTTTCTGGTAAAGATTAATGCCAAT
ATCGGTAACTCAGCGCTGGGCTCAAGCATTGATGAGGAAGTATCCAAGATGACCTGGGCTACCCGCTGGGGCGCCGACAC
CATCATGGATTTATCGACCGGTAAGAATATTCATGAAACTCGTGAATGGATTATCCGCAACTCGCCTGTACCCATTGGCA
CTGTCCCTATTTATCAAGCATTAGAGAAAGTTGACGGCGTCGCTGAAGACTTAACGTGGGAGATTTTCCGCGATACATTA
ATTGAGCAAGCCGAGCAAGGCGTGGATTACTTTACTATTCACGCCGGCGTGCTACTGCGCTATGTACCCCTAACTGCAAA
ACGTCTAACTGGCATTGTGTCGCGCGGCGGCTCTATCATGGCGCAGTGGTGTCTTGCTCATCACAAAGAAAGCTTCTTGT
ATACCCATTTTGAAGACATCTGCGACATCATGAAGCAGTATGACGTGGCCTTTAGCTTAGGCGATGGCCTACGTCCAGGC
TGTTTGCAAGACGCCAATGATGAGGCTCAGTTTGGCGAGCTGAAAACCTTAGGCGAGCTGACTCAAGTGGCTTGGAAGCA
TGATGTACAGGTGATGATTGAAGGGCCAGGTCATGTGGCGATGAACCGCATTAAAGAGAACATGGATTTGCAGCTTGAGA
TGTGTTCTGAGGCACCTTTTTATACCCTTGGTCCATTAACCACAGACATCGCGCCAGGCTATGATCACATTACCAGTGCT
ATTGGCGCCGCTATGATTGGCTGGTTTGGCACGGCAATGCTGTGTTATGTGACCCCAAAAGAGCATTTAGGTCTGCCTAA
TAAAAAAGACGTGAAAGATGGCATCATCACTTACAAAATCGCCGCTCACGCCGCTGACCTAGCCAAAGGCCACCCTGGCG
CTCAGGCACGTGATAATGCGTTATCGAAAGCCCGCTTTGAGTTCCGCTGGGATGATCAGTTTAATCTAGCCTTAGATCCA
GACACGGCTCGTGAATTCCATGATGAAACACTGCCAAAAGATGCGCACAAGTCTGCCCATTTCTGCTCTATGTGTGGGCC
TAAGTTTTGCTCAATGAAAATCACCCAAAATGTGCGTGAGTATGCAGCCGGCCTGCCTACCGGTGTTGAGGTCACCCCAA
GCAGTGGCGAGCTTAGTGATGCGGTGCATCTTATCAAAGAGGTCGACACTGAACTGGTTAAAAAAGTAGGTGAAGCCAGT
TTTGAAGAGGTACAAAAGGGCATGGCTCAGATGACAGAGAAGTATAATAGCGAGGGACGCCAGCTTTATAAAGAGGTGTA
A

Upstream 100 bases:

>100_bases
TCTGCACTCACTGAGTCTTTATTTTTACTACCGGTTTTTAGCCTTTTACCCTAAAAGCCTCTATGGCACCTTGCCATTAA
CAAAAAATAAGGACATTTCT

Downstream 100 bases:

>100_bases
GCTTTACTGTAGGAAAAAGGTCTTTAATCCCAATCGCCATTTTTATTAAATAAAAAGCTTGAACCTCTAGATGGAGGTTC
AAGCTTTTTTTAGCTTTTCT

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSNEQHTIKTPAHRNVKDERFDEEARDLTRSLPASRKIYIEGSRPDIQVPMREITLTDTPTGGFGLENGEKNPPFYVYDT
SGVYTDPSVDIDLTKGLPKLREKWIEERGDTEVLDGLSSNYGQERARDIKTANIRFAHIDKPRRAKAGKNVTQMHYARQG
IITPEMEYIAIRETQKQHELTDMRQHAGETFGANTPKIITPEFVRAEVAAGRAIIPNNINHPESEPMIIGRNFLVKINAN
IGNSALGSSIDEEVSKMTWATRWGADTIMDLSTGKNIHETREWIIRNSPVPIGTVPIYQALEKVDGVAEDLTWEIFRDTL
IEQAEQGVDYFTIHAGVLLRYVPLTAKRLTGIVSRGGSIMAQWCLAHHKESFLYTHFEDICDIMKQYDVAFSLGDGLRPG
CLQDANDEAQFGELKTLGELTQVAWKHDVQVMIEGPGHVAMNRIKENMDLQLEMCSEAPFYTLGPLTTDIAPGYDHITSA
IGAAMIGWFGTAMLCYVTPKEHLGLPNKKDVKDGIITYKIAAHAADLAKGHPGAQARDNALSKARFEFRWDDQFNLALDP
DTAREFHDETLPKDAHKSAHFCSMCGPKFCSMKITQNVREYAAGLPTGVEVTPSSGELSDAVHLIKEVDTELVKKVGEAS
FEEVQKGMAQMTEKYNSEGRQLYKEV

Sequences:

>Translated_666_residues
MSNEQHTIKTPAHRNVKDERFDEEARDLTRSLPASRKIYIEGSRPDIQVPMREITLTDTPTGGFGLENGEKNPPFYVYDT
SGVYTDPSVDIDLTKGLPKLREKWIEERGDTEVLDGLSSNYGQERARDIKTANIRFAHIDKPRRAKAGKNVTQMHYARQG
IITPEMEYIAIRETQKQHELTDMRQHAGETFGANTPKIITPEFVRAEVAAGRAIIPNNINHPESEPMIIGRNFLVKINAN
IGNSALGSSIDEEVSKMTWATRWGADTIMDLSTGKNIHETREWIIRNSPVPIGTVPIYQALEKVDGVAEDLTWEIFRDTL
IEQAEQGVDYFTIHAGVLLRYVPLTAKRLTGIVSRGGSIMAQWCLAHHKESFLYTHFEDICDIMKQYDVAFSLGDGLRPG
CLQDANDEAQFGELKTLGELTQVAWKHDVQVMIEGPGHVAMNRIKENMDLQLEMCSEAPFYTLGPLTTDIAPGYDHITSA
IGAAMIGWFGTAMLCYVTPKEHLGLPNKKDVKDGIITYKIAAHAADLAKGHPGAQARDNALSKARFEFRWDDQFNLALDP
DTAREFHDETLPKDAHKSAHFCSMCGPKFCSMKITQNVREYAAGLPTGVEVTPSSGELSDAVHLIKEVDTELVKKVGEAS
FEEVQKGMAQMTEKYNSEGRQLYKEV
>Mature_665_residues
SNEQHTIKTPAHRNVKDERFDEEARDLTRSLPASRKIYIEGSRPDIQVPMREITLTDTPTGGFGLENGEKNPPFYVYDTS
GVYTDPSVDIDLTKGLPKLREKWIEERGDTEVLDGLSSNYGQERARDIKTANIRFAHIDKPRRAKAGKNVTQMHYARQGI
ITPEMEYIAIRETQKQHELTDMRQHAGETFGANTPKIITPEFVRAEVAAGRAIIPNNINHPESEPMIIGRNFLVKINANI
GNSALGSSIDEEVSKMTWATRWGADTIMDLSTGKNIHETREWIIRNSPVPIGTVPIYQALEKVDGVAEDLTWEIFRDTLI
EQAEQGVDYFTIHAGVLLRYVPLTAKRLTGIVSRGGSIMAQWCLAHHKESFLYTHFEDICDIMKQYDVAFSLGDGLRPGC
LQDANDEAQFGELKTLGELTQVAWKHDVQVMIEGPGHVAMNRIKENMDLQLEMCSEAPFYTLGPLTTDIAPGYDHITSAI
GAAMIGWFGTAMLCYVTPKEHLGLPNKKDVKDGIITYKIAAHAADLAKGHPGAQARDNALSKARFEFRWDDQFNLALDPD
TAREFHDETLPKDAHKSAHFCSMCGPKFCSMKITQNVREYAAGLPTGVEVTPSSGELSDAVHLIKEVDTELVKKVGEASF
EEVQKGMAQMTEKYNSEGRQLYKEV

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=577, Percent_Identity=72.2703639514731, Blast_Score=884, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 74466; Mature: 74335

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEQHTIKTPAHRNVKDERFDEEARDLTRSLPASRKIYIEGSRPDIQVPMREITLTDTP
CCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
TGGFGLENGEKNPPFYVYDTSGVYTDPSVDIDLTKGLPKLREKWIEERGDTEVLDGLSSN
CCCCCCCCCCCCCCEEEEECCCEECCCCCCEEHHCCCHHHHHHHHHHCCCHHHHHHHHHC
YGQERARDIKTANIRFAHIDKPRRAKAGKNVTQMHYARQGIITPEMEYIAIRETQKQHEL
CCHHHHHHHHHCCEEEEECCCCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHHH
TDMRQHAGETFGANTPKIITPEFVRAEVAAGRAIIPNNINHPESEPMIIGRNFLVKINAN
HHHHHHCCCCCCCCCCCEECHHHHHHHHHCCCEECCCCCCCCCCCCEEECCEEEEEEECC
IGNSALGSSIDEEVSKMTWATRWGADTIMDLSTGKNIHETREWIIRNSPVPIGTVPIYQA
CCCHHHCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
LEKVDGVAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRLTGIVSRGGSIM
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHH
AQWCLAHHKESFLYTHFEDICDIMKQYDVAFSLGDGLRPGCLQDANDEAQFGELKTLGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
TQVAWKHDVQVMIEGPGHVAMNRIKENMDLQLEMCSEAPFYTLGPLTTDIAPGYDHITSA
HHHHHHCCCEEEEECCCHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCHHHHHHH
IGAAMIGWFGTAMLCYVTPKEHLGLPNKKDVKDGIITYKIAAHAADLAKGHPGAQARDNA
HHHHHHHHHHHEEEEEECCHHHCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHH
LSKARFEFRWDDQFNLALDPDTAREFHDETLPKDAHKSAHFCSMCGPKFCSMKITQNVRE
HHHCEEEEEECCCEEEEECCHHHHHHHHHCCCCHHHCCHHHHHHCCCHHHHHHHHHHHHH
YAAGLPTGVEVTPSSGELSDAVHLIKEVDTELVKKVGEASFEEVQKGMAQMTEKYNSEGR
HHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QLYKEV
HHHHCC
>Mature Secondary Structure 
SNEQHTIKTPAHRNVKDERFDEEARDLTRSLPASRKIYIEGSRPDIQVPMREITLTDTP
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
TGGFGLENGEKNPPFYVYDTSGVYTDPSVDIDLTKGLPKLREKWIEERGDTEVLDGLSSN
CCCCCCCCCCCCCCEEEEECCCEECCCCCCEEHHCCCHHHHHHHHHHCCCHHHHHHHHHC
YGQERARDIKTANIRFAHIDKPRRAKAGKNVTQMHYARQGIITPEMEYIAIRETQKQHEL
CCHHHHHHHHHCCEEEEECCCCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHHH
TDMRQHAGETFGANTPKIITPEFVRAEVAAGRAIIPNNINHPESEPMIIGRNFLVKINAN
HHHHHHCCCCCCCCCCCEECHHHHHHHHHCCCEECCCCCCCCCCCCEEECCEEEEEEECC
IGNSALGSSIDEEVSKMTWATRWGADTIMDLSTGKNIHETREWIIRNSPVPIGTVPIYQA
CCCHHHCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
LEKVDGVAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRLTGIVSRGGSIM
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHH
AQWCLAHHKESFLYTHFEDICDIMKQYDVAFSLGDGLRPGCLQDANDEAQFGELKTLGEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
TQVAWKHDVQVMIEGPGHVAMNRIKENMDLQLEMCSEAPFYTLGPLTTDIAPGYDHITSA
HHHHHHCCCEEEEECCCHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCHHHHHHH
IGAAMIGWFGTAMLCYVTPKEHLGLPNKKDVKDGIITYKIAAHAADLAKGHPGAQARDNA
HHHHHHHHHHHEEEEEECCHHHCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCHHHHH
LSKARFEFRWDDQFNLALDPDTAREFHDETLPKDAHKSAHFCSMCGPKFCSMKITQNVRE
HHHCEEEEEECCCEEEEECCHHHHHHHHHCCCCHHHCCHHHHHHCCCHHHHHHHHHHHHH
YAAGLPTGVEVTPSSGELSDAVHLIKEVDTELVKKVGEASFEEVQKGMAQMTEKYNSEGR
HHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QLYKEV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA