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The map label for this gene is accC [H]

Identifier: 148654020

GI number: 148654020

Start: 2763724

End: 2765070

Strand: Direct

Name: accC [H]

Synonym: PsycPRwf_2223

Alternate gene names: 148654020

Gene position: 2763724-2765070 (Clockwise)

Preceding gene: 148654019

Following gene: 148654021

Centisome position: 92.77

GC content: 45.66

Gene sequence:

>1347_bases
ATGTTCAAAAAAATTCTGATAGCCAATAGGGGTGAGATTGCCCTACGTATTGTCCGTGCCTGTCAACAAATGGGCATTAA
ATCAGTGGTGGTATATTCTCAATCAGATAAAGATACGCTTGATGTAAGATTAGCGGATGAAAGTGTCTGTATCGGCCCTG
CACCTGCTTCTAAAAGTTATTTAAACCAAGAAGCCATCATTTCAGCAGCACTCATGAGCGGTGCTGAAGCCATTCACCCC
GGCTATGGATTTTTAGCCGAAAACGCCGCTTTTGCTGAAGCGGTAACTGACGCAGGATTGGTTTTTATTGGCCCTACTGC
ACAAAACATTCGTCAAATGGGCGACAAAGTAGAAGCCAAAAAACAAATGCTACTAGCGGGTGTTCCTTGTGTCCCTGGCT
CTGAGGGCGCCTTGCCAGAAACTGAAAATGAGGTATTGGCACTCGCCGAGAAGGTGGGCTATCCGGTGATTATTAAAGCG
GCCAGCGGTGGTGGTGGCCGTGGTATGCGTGTGGTCGACAAACAAAGTGAGCTGCTTAAAGCCATTGCAATGACCAAGAG
TGAAGCGGAAGCCAACTTTGGTGATTCTGTGGTGTATCTTGAACGTTATTTACAAAAACCACGTCATATCGAGGTGCAAG
TCTTGGCCGATACCCAAGGCCACGCGATTCACTTAGGTGAGCGTGATTGCTCAATGCAGCGCCGCCATCAAAAAGTGATT
GAAGAAGCCCCTGCTCCAGGTATCAGTGAATCACAGCGTCAACAAATTGGTGAGGCCTGCGTTAATGCCTGCAAGAGAAT
GGGCTATGTTGGTGCGGGTACGTTTGAATTTTTATATGAAAATGGCGAGTTTTTTTTCATCGAGATGAATACCCGCATTC
AAGTGGAGCATACCATCACCGAGTTGGTGAGTGGTATTGATATTGTCCAAGCTCAAATTACCGTAGCTGCAGGTCTACCT
TTATCGTATCAACAGACTGATGTTAAGCTTTCTGGCCATGCGTTTGAATGCCGAATTAATGCCGAAAATCCTTACACCTT
TTTACCGACACCCGGCAAAATCAGCTATTGCCACTTCCCTGCAGGTATGGGCGTACGTGTCGACAGTCATGTTGAGTCAG
GCTCAGTGATTCCCCCCTCTTATGACAGTCTGGTGGCCAAAATATGTGTTTATGCAGCAGACAGAGCCACGGCAGTGAAT
TATATGCAAGCAGCACTCAAGGAAGCTAGCATAGAAGGCATTGATACCAATTTAGCTTTACATAAGCGCTTATTTGAGGA
TAAAGGCTTTCAAGAAGGTGAGGTTAGTATCCATTATTTAGAACAGTGGATTGAGCAAAATATTTAA

Upstream 100 bases:

>100_bases
ACGCTGTAAAGCAAATTCGTACCCTCTGCTTCATTTATCATTTTATGACACGCATTATTACCCTGTGTAACCTTTAACCT
GCCTCTGCAAGGAAGCCGAT

Downstream 100 bases:

>100_bases
TTGACTCTATATTATCAACCCTTAAAGGACTTAAGGCATGCCAAACTTGATCAGTAATGCTGAACTCAACAGCCCTGACC
AGCCCACTTGGCAATTATGT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFKKILIANRGEIALRIVRACQQMGIKSVVVYSQSDKDTLDVRLADESVCIGPAPASKSYLNQEAIISAALMSGAEAIHP
GYGFLAENAAFAEAVTDAGLVFIGPTAQNIRQMGDKVEAKKQMLLAGVPCVPGSEGALPETENEVLALAEKVGYPVIIKA
ASGGGGRGMRVVDKQSELLKAIAMTKSEAEANFGDSVVYLERYLQKPRHIEVQVLADTQGHAIHLGERDCSMQRRHQKVI
EEAPAPGISESQRQQIGEACVNACKRMGYVGAGTFEFLYENGEFFFIEMNTRIQVEHTITELVSGIDIVQAQITVAAGLP
LSYQQTDVKLSGHAFECRINAENPYTFLPTPGKISYCHFPAGMGVRVDSHVESGSVIPPSYDSLVAKICVYAADRATAVN
YMQAALKEASIEGIDTNLALHKRLFEDKGFQEGEVSIHYLEQWIEQNI

Sequences:

>Translated_448_residues
MFKKILIANRGEIALRIVRACQQMGIKSVVVYSQSDKDTLDVRLADESVCIGPAPASKSYLNQEAIISAALMSGAEAIHP
GYGFLAENAAFAEAVTDAGLVFIGPTAQNIRQMGDKVEAKKQMLLAGVPCVPGSEGALPETENEVLALAEKVGYPVIIKA
ASGGGGRGMRVVDKQSELLKAIAMTKSEAEANFGDSVVYLERYLQKPRHIEVQVLADTQGHAIHLGERDCSMQRRHQKVI
EEAPAPGISESQRQQIGEACVNACKRMGYVGAGTFEFLYENGEFFFIEMNTRIQVEHTITELVSGIDIVQAQITVAAGLP
LSYQQTDVKLSGHAFECRINAENPYTFLPTPGKISYCHFPAGMGVRVDSHVESGSVIPPSYDSLVAKICVYAADRATAVN
YMQAALKEASIEGIDTNLALHKRLFEDKGFQEGEVSIHYLEQWIEQNI
>Mature_448_residues
MFKKILIANRGEIALRIVRACQQMGIKSVVVYSQSDKDTLDVRLADESVCIGPAPASKSYLNQEAIISAALMSGAEAIHP
GYGFLAENAAFAEAVTDAGLVFIGPTAQNIRQMGDKVEAKKQMLLAGVPCVPGSEGALPETENEVLALAEKVGYPVIIKA
ASGGGGRGMRVVDKQSELLKAIAMTKSEAEANFGDSVVYLERYLQKPRHIEVQVLADTQGHAIHLGERDCSMQRRHQKVI
EEAPAPGISESQRQQIGEACVNACKRMGYVGAGTFEFLYENGEFFFIEMNTRIQVEHTITELVSGIDIVQAQITVAAGLP
LSYQQTDVKLSGHAFECRINAENPYTFLPTPGKISYCHFPAGMGVRVDSHVESGSVIPPSYDSLVAKICVYAADRATAVN
YMQAALKEASIEGIDTNLALHKRLFEDKGFQEGEVSIHYLEQWIEQNI

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=446, Percent_Identity=44.1704035874439, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=44.920993227991, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=44.920993227991, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=44.920993227991, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=43.4004474272931, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=43.4004474272931, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=43.4004474272931, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=30.5882352941176, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=30.5882352941176, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=30.5882352941176, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI38679960, Length=510, Percent_Identity=30.5882352941176, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=30.5882352941176, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=28.9628180039139, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=59.9547511312217, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=45.578231292517, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=45.372460496614, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=42.7937915742794, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=28.1800391389432, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=28.1800391389432, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=27.4949083503055, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=42.6008968609865, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=42.8571428571429, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=43.652561247216, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6324343, Length=515, Percent_Identity=28.5436893203883, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=457, Percent_Identity=31.0722100656455, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=47.2035794183445, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=47.5490196078431, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=45.413870246085, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076409, Length=506, Percent_Identity=30.6324110671937, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=30.6324110671937, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161076407, Length=506, Percent_Identity=30.6324110671937, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24586460, Length=506, Percent_Identity=30.6324110671937, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48699; Mature: 48699

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIALRIVRACQQMGIKSVVVYSQSDKDTLDVRLADESVCIGPAPASKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCCHHH
LNQEAIISAALMSGAEAIHPGYGFLAENAAFAEAVTDAGLVFIGPTAQNIRQMGDKVEAK
CCHHHHHHHHHHCCCHHCCCCCCHHHCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
KQMLLAGVPCVPGSEGALPETENEVLALAEKVGYPVIIKAASGGGGRGMRVVDKQSELLK
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEECHHHHHHH
AIAMTKSEAEANFGDSVVYLERYLQKPRHIEVQVLADTQGHAIHLGERDCSMQRRHQKVI
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGISESQRQQIGEACVNACKRMGYVGAGTFEFLYENGEFFFIEMNTRIQVEHTIT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
ELVSGIDIVQAQITVAAGLPLSYQQTDVKLSGHAFECRINAENPYTFLPTPGKISYCHFP
HHHCCCHHEEEEEEEEECCCCCCCCCCEEECCCEEEEEECCCCCEEECCCCCCEEEEECC
AGMGVRVDSHVESGSVIPPSYDSLVAKICVYAADRATAVNYMQAALKEASIEGIDTNLAL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHH
HKRLFEDKGFQEGEVSIHYLEQWIEQNI
HHHHHHHCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFKKILIANRGEIALRIVRACQQMGIKSVVVYSQSDKDTLDVRLADESVCIGPAPASKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCCHHH
LNQEAIISAALMSGAEAIHPGYGFLAENAAFAEAVTDAGLVFIGPTAQNIRQMGDKVEAK
CCHHHHHHHHHHCCCHHCCCCCCHHHCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
KQMLLAGVPCVPGSEGALPETENEVLALAEKVGYPVIIKAASGGGGRGMRVVDKQSELLK
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEECHHHHHHH
AIAMTKSEAEANFGDSVVYLERYLQKPRHIEVQVLADTQGHAIHLGERDCSMQRRHQKVI
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGISESQRQQIGEACVNACKRMGYVGAGTFEFLYENGEFFFIEMNTRIQVEHTIT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
ELVSGIDIVQAQITVAAGLPLSYQQTDVKLSGHAFECRINAENPYTFLPTPGKISYCHFP
HHHCCCHHEEEEEEEEECCCCCCCCCCEEECCCEEEEEECCCCCEEECCCCCCEEEEECC
AGMGVRVDSHVESGSVIPPSYDSLVAKICVYAADRATAVNYMQAALKEASIEGIDTNLAL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHH
HKRLFEDKGFQEGEVSIHYLEQWIEQNI
HHHHHHHCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]