Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 148653807

GI number: 148653807

Start: 2502025

End: 2503362

Strand: Direct

Name: hom [H]

Synonym: PsycPRwf_2010

Alternate gene names: 148653807

Gene position: 2502025-2503362 (Clockwise)

Preceding gene: 148653806

Following gene: 148653808

Centisome position: 83.99

GC content: 46.34

Gene sequence:

>1338_bases
GTGAGTAAATCAATTAAATTGGCTATATTAGGGCTGGGCACTGTAGGTACAGGTGTCTTAGACCTACTTCAAGATAACTT
ATCAGAGCTAAAGAGGCGCAGTGGTCACGACATTGTTATTACCCAAGTCGGTACCCGCCGTCAGCGTGATGACATTGATC
CCAGTATTAAGCAGCAAAGTGACTTAATGGCCATTGCCCAAAGCGACGATGTGGATATTATTGTTGAGGTAATTGGTGGC
CAAACCGTAGCCAAAGAGGTGATTATCCACGCCATAAAAAATGGCAAACATGTGGTTACTGCTAACAAGGCGCTACTGGC
CGAACATGGTAATGAGATTTTTGACCTCGCTGATAAGCACAACGTCCATGTGGCTTATGAAGCAGCTGTGGCAGGCGGTA
TTCCTATTATTAAAGTGCTGCGTGAAGCTTTAGCGGCCAATAAAGTAGATTGGCTCACCGGTATTATTAATGGTACGGGC
AACTTTATTATGTCAGAGATGCGCGATAAAGGCCGCACCTTTGAAGATGTGTTAGCAGAAGCCCAAGCGCTGGGGTATGC
TGAGGCAGATCCTACCTTTGATGTCGAGGGTATTGATGCGGCGCATAAATTAGCGCTACTGGCCTCAATTGCCTTTGGTA
TCCCCTTACAATTTGATAAAGTTTACTGTGAAGGCATTACCGCTATCACTTTGCAGGATGTCACATACGCTGAAGAGTTG
GGCTATCGTATCAAGCACTTAGGCTTTGCGGTACGTCGTTATGATGGGCAAGACCCTCAATCGGTTAGCAAAAAAGTAAC
CGGTATTGAGCTGCGCGTCCATCCGACCCTTATCCCACAAGATAAGCTGTTGGCCAATGTTAATGGTGTAAAAAACGCGG
TACTGGTCAATTCGCATCCTTTAGGTCAGACTCTATACTATGGCGATGGCGCAGGTGCCGGAGCCACTGCGTCTGCGGTC
ATGGCCGATGTGATGGATTTAATTCGGGTATTGACCGTAAAAGATGGCCATCATGTACCGCACTTAGCGTTTATGCCCAA
CCAATTATCAGACACCCCCATCTTGCCTGCTGAGCAGATGGTAACCGGCTATTACTTACGTTTGCAGGCCACCGATACCC
CAGGTGTACTGGCTGACGTGACTCGTATCTTAAGTGATGCCGGCATTAACATTGATGCCATTTTACAAAAACCGGCACAT
CAAAAAGGACAGGTGCCTATCATCATTTTAACGCTACCGGTTATTGAAAGTCAGATGAATGTCGCCATTAAGAAGATTGA
AGCCTTGCAAGCGATTACATCAGATGTGGTACGTATTCGCTTAAATGAGCTGGACTAA

Upstream 100 bases:

>100_bases
TACACTATGATGCATAAGAGGCGTACATACGGCGCTGTATCACGCGCTCTGCAAGCTTGAACAATCGATAATAACGTTGG
ATAACACTACTGAGGATACC

Downstream 100 bases:

>100_bases
AAAACTTAGACTAAAAGGGTTAGACTAAGACATTAACAGAAGCAAATTAAGTGATCGATTTGGCCAAGCTATCAAGTCGC
TTGGCTCTTAAATAAATAAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSKSIKLAILGLGTVGTGVLDLLQDNLSELKRRSGHDIVITQVGTRRQRDDIDPSIKQQSDLMAIAQSDDVDIIVEVIGG
QTVAKEVIIHAIKNGKHVVTANKALLAEHGNEIFDLADKHNVHVAYEAAVAGGIPIIKVLREALAANKVDWLTGIINGTG
NFIMSEMRDKGRTFEDVLAEAQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITAITLQDVTYAEEL
GYRIKHLGFAVRRYDGQDPQSVSKKVTGIELRVHPTLIPQDKLLANVNGVKNAVLVNSHPLGQTLYYGDGAGAGATASAV
MADVMDLIRVLTVKDGHHVPHLAFMPNQLSDTPILPAEQMVTGYYLRLQATDTPGVLADVTRILSDAGINIDAILQKPAH
QKGQVPIIILTLPVIESQMNVAIKKIEALQAITSDVVRIRLNELD

Sequences:

>Translated_445_residues
MSKSIKLAILGLGTVGTGVLDLLQDNLSELKRRSGHDIVITQVGTRRQRDDIDPSIKQQSDLMAIAQSDDVDIIVEVIGG
QTVAKEVIIHAIKNGKHVVTANKALLAEHGNEIFDLADKHNVHVAYEAAVAGGIPIIKVLREALAANKVDWLTGIINGTG
NFIMSEMRDKGRTFEDVLAEAQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITAITLQDVTYAEEL
GYRIKHLGFAVRRYDGQDPQSVSKKVTGIELRVHPTLIPQDKLLANVNGVKNAVLVNSHPLGQTLYYGDGAGAGATASAV
MADVMDLIRVLTVKDGHHVPHLAFMPNQLSDTPILPAEQMVTGYYLRLQATDTPGVLADVTRILSDAGINIDAILQKPAH
QKGQVPIIILTLPVIESQMNVAIKKIEALQAITSDVVRIRLNELD
>Mature_444_residues
SKSIKLAILGLGTVGTGVLDLLQDNLSELKRRSGHDIVITQVGTRRQRDDIDPSIKQQSDLMAIAQSDDVDIIVEVIGGQ
TVAKEVIIHAIKNGKHVVTANKALLAEHGNEIFDLADKHNVHVAYEAAVAGGIPIIKVLREALAANKVDWLTGIINGTGN
FIMSEMRDKGRTFEDVLAEAQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITAITLQDVTYAEELG
YRIKHLGFAVRRYDGQDPQSVSKKVTGIELRVHPTLIPQDKLLANVNGVKNAVLVNSHPLGQTLYYGDGAGAGATASAVM
ADVMDLIRVLTVKDGHHVPHLAFMPNQLSDTPILPAEQMVTGYYLRLQATDTPGVLADVTRILSDAGINIDAILQKPAHQ
KGQVPIIILTLPVIESQMNVAIKKIEALQAITSDVVRIRLNELD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=374, Percent_Identity=26.2032085561497, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786183, Length=287, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322599, Length=237, Percent_Identity=27.4261603375527, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 48011; Mature: 47880

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSIKLAILGLGTVGTGVLDLLQDNLSELKRRSGHDIVITQVGTRRQRDDIDPSIKQQS
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHCCC
DLMAIAQSDDVDIIVEVIGGQTVAKEVIIHAIKNGKHVVTANKALLAEHGNEIFDLADKH
CEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCHHEECCCCC
NVHVAYEAAVAGGIPIIKVLREALAANKVDWLTGIINGTGNFIMSEMRDKGRTFEDVLAE
CEEEEEEHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHH
AQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITAITLQDVTYAEEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECHHHHCCEEEEEEECHHHHHHH
GYRIKHLGFAVRRYDGQDPQSVSKKVTGIELRVHPTLIPQDKLLANVNGVKNAVLVNSHP
CHHHHHHHHHHHHCCCCCHHHHHHHHEEEEEEEECCCCCCHHHHHCCCCCCCEEEEECCC
LGQTLYYGDGAGAGATASAVMADVMDLIRVLTVKDGHHVPHLAFMPNQLSDTPILPAEQM
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHH
VTGYYLRLQATDTPGVLADVTRILSDAGINIDAILQKPAHQKGQVPIIILTLPVIESQMN
CCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECHHHHHHH
VAIKKIEALQAITSDVVRIRLNELD
HHHHHHHHHHHHHHHHHEEEEECCC
>Mature Secondary Structure 
SKSIKLAILGLGTVGTGVLDLLQDNLSELKRRSGHDIVITQVGTRRQRDDIDPSIKQQS
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHCCC
DLMAIAQSDDVDIIVEVIGGQTVAKEVIIHAIKNGKHVVTANKALLAEHGNEIFDLADKH
CEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCHHEECCCCC
NVHVAYEAAVAGGIPIIKVLREALAANKVDWLTGIINGTGNFIMSEMRDKGRTFEDVLAE
CEEEEEEHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHH
AQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITAITLQDVTYAEEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECHHHHCCEEEEEEECHHHHHHH
GYRIKHLGFAVRRYDGQDPQSVSKKVTGIELRVHPTLIPQDKLLANVNGVKNAVLVNSHP
CHHHHHHHHHHHHCCCCCHHHHHHHHEEEEEEEECCCCCCHHHHHCCCCCCCEEEEECCC
LGQTLYYGDGAGAGATASAVMADVMDLIRVLTVKDGHHVPHLAFMPNQLSDTPILPAEQM
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHH
VTGYYLRLQATDTPGVLADVTRILSDAGINIDAILQKPAHQKGQVPIIILTLPVIESQMN
CCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECHHHHHHH
VAIKKIEALQAITSDVVRIRLNELD
HHHHHHHHHHHHHHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]