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The map label for this gene is hemB [H]

Identifier: 148653619

GI number: 148653619

Start: 2262470

End: 2263480

Strand: Direct

Name: hemB [H]

Synonym: PsycPRwf_1822

Alternate gene names: 148653619

Gene position: 2262470-2263480 (Clockwise)

Preceding gene: 148653610

Following gene: 148653621

Centisome position: 75.95

GC content: 46.88

Gene sequence:

>1011_bases
ATGAGTTATACATTTAATCGCACTTTTCCTCATACCCGCTTACGCCGCTTACGCGTCCATGACAATGTGCGTGCCATGAT
TCGTGAAGTTGAGCTGCATCCCAAACATCTCATTGCTCCTGTTTTCGTCTTAGAAGGTGAAAACCAGCGTGAAGCTGTGG
CCAGTATGCCAGGTGTGGATCGTTTATCTATTGATCTGCTGGTGCAATATGCCAAAGAGTTATTGGCTGAGGGAGTCACT
ACCGTAGATATCTTCCCTGTTATCGATGCCAGCTTGAAGACAGAAGATGGCCGTGAAGCGGCTAATCCAGATGGCTTAAC
TTGCCGTGCCGTACGGGCACTAAAAAAAGAAGTGCCTGAGATGGTGGTGATGACCGATGTGGCATTAGACCCTTATACCA
CCCACGGTCAAGATGGCCTATTAGATGAGTCAGGCTATGTGGTCAATGATGAAACTGTGGAGGTTCTGGTTGAGCAAACA
CTGGCACACGCCCGCGCTGGTGCAGATATCATCTCACCAAGTGATATGATGGATGGCCGTATACTGGCTATGCGTGAAGC
ATTGGAAGATGAAGGCTTTGTGAATACAGCACTTATGGCTTATTCTGCCAAATACGCGTCTGCTTATTATGGCCCTTTCC
GTGACGCTGTAGGCAGTGCTGGCAATCTAAAAGGCGGTCATAAGAAGCAGTATCAAATGGACTTTGGTAACCGCGCGGAA
GCCTTGCATGAAGTAGCAATGGACATCAATGAGGGCGCTGATATGGTAATGATTAAACCCGGTCAGCCATATTTAGATTT
GATACGTGAGGTAAAAGATACCTTTGGCGTCCCTACTTTCGCTTATCAAGTATCGGGTGAATATGCGATGCATATGGCGG
CCATTCAAAATGGCTGGCTTACCGATTCGGTTATTTTAGAGTCATTAATGGGCTTTAGACGGGCAGGCGCTGATGGCATC
TTAACTTATTTTGCGCTAGAAGCTGCCAAACAGCTCAACGCTTTAAAATAA

Upstream 100 bases:

>100_bases
ACCCTTATTCTGCTTTTGATCCCTAAAGACCTACTTTGGGTCACTTAATGTCTACCCTACCCTCCCATTTCTTAATTCGT
TAAAGTTATTAGGACTTATT

Downstream 100 bases:

>100_bases
GTAGTTTTGATTTGATGTAAAAAACCCCCGTATCTGATGGATACGGGGGTTTTTATTTCAGCCGGCTTATTTTAAGCCAA
CTTTATTAACAGGCTAGATT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSYTFNRTFPHTRLRRLRVHDNVRAMIREVELHPKHLIAPVFVLEGENQREAVASMPGVDRLSIDLLVQYAKELLAEGVT
TVDIFPVIDASLKTEDGREAANPDGLTCRAVRALKKEVPEMVVMTDVALDPYTTHGQDGLLDESGYVVNDETVEVLVEQT
LAHARAGADIISPSDMMDGRILAMREALEDEGFVNTALMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKDTFGVPTFAYQVSGEYAMHMAAIQNGWLTDSVILESLMGFRRAGADGI
LTYFALEAAKQLNALK

Sequences:

>Translated_336_residues
MSYTFNRTFPHTRLRRLRVHDNVRAMIREVELHPKHLIAPVFVLEGENQREAVASMPGVDRLSIDLLVQYAKELLAEGVT
TVDIFPVIDASLKTEDGREAANPDGLTCRAVRALKKEVPEMVVMTDVALDPYTTHGQDGLLDESGYVVNDETVEVLVEQT
LAHARAGADIISPSDMMDGRILAMREALEDEGFVNTALMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKDTFGVPTFAYQVSGEYAMHMAAIQNGWLTDSVILESLMGFRRAGADGI
LTYFALEAAKQLNALK
>Mature_335_residues
SYTFNRTFPHTRLRRLRVHDNVRAMIREVELHPKHLIAPVFVLEGENQREAVASMPGVDRLSIDLLVQYAKELLAEGVTT
VDIFPVIDASLKTEDGREAANPDGLTCRAVRALKKEVPEMVVMTDVALDPYTTHGQDGLLDESGYVVNDETVEVLVEQTL
AHARAGADIISPSDMMDGRILAMREALEDEGFVNTALMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAEA
LHEVAMDINEGADMVMIKPGQPYLDLIREVKDTFGVPTFAYQVSGEYAMHMAAIQNGWLTDSVILESLMGFRRAGADGIL
TYFALEAAKQLNALK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=328, Percent_Identity=40.5487804878049, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI87081728, Length=320, Percent_Identity=45, Blast_Score=241, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=34.4827586206897, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21358291, Length=298, Percent_Identity=40.9395973154362, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37090; Mature: 36959

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTFNRTFPHTRLRRLRVHDNVRAMIREVELHPKHLIAPVFVLEGENQREAVASMPGVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEEEEECCCHHHHHHHCCCCC
RLSIDLLVQYAKELLAEGVTTVDIFPVIDASLKTEDGREAANPDGLTCRAVRALKKEVPE
HHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
MVVMTDVALDPYTTHGQDGLLDESGYVVNDETVEVLVEQTLAHARAGADIISPSDMMDGR
EEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCH
ILAMREALEDEGFVNTALMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCEEECCCCCHHH
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKDTFGVPTFAYQVSGEYAMHMAAIQNGWL
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCC
TDSVILESLMGFRRAGADGILTYFALEAAKQLNALK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYTFNRTFPHTRLRRLRVHDNVRAMIREVELHPKHLIAPVFVLEGENQREAVASMPGVD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEEEEECCCHHHHHHHCCCCC
RLSIDLLVQYAKELLAEGVTTVDIFPVIDASLKTEDGREAANPDGLTCRAVRALKKEVPE
HHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
MVVMTDVALDPYTTHGQDGLLDESGYVVNDETVEVLVEQTLAHARAGADIISPSDMMDGR
EEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCH
ILAMREALEDEGFVNTALMAYSAKYASAYYGPFRDAVGSAGNLKGGHKKQYQMDFGNRAE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCEEECCCCCHHH
ALHEVAMDINEGADMVMIKPGQPYLDLIREVKDTFGVPTFAYQVSGEYAMHMAAIQNGWL
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCC
TDSVILESLMGFRRAGADGILTYFALEAAKQLNALK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]