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The map label for this gene is lpdA [H]

Identifier: 148653566

GI number: 148653566

Start: 2188752

End: 2190299

Strand: Direct

Name: lpdA [H]

Synonym: PsycPRwf_1769

Alternate gene names: 148653566

Gene position: 2188752-2190299 (Clockwise)

Preceding gene: 148653565

Following gene: 148653567

Centisome position: 73.47

GC content: 45.67

Gene sequence:

>1548_bases
ATGACAAAACCTGCAATAGACTCTCAAAAATCCATTCGTTATGTTGATGCTGCTGTGATTGGTGCAGGTACGGCAGGCCA
TAATGCTTATCGTCAGATTAGCAAGGTAACAGACAATGTGGTCATTATTAACGAAGGTATCTGGTCAACAACTTGTACCA
CCATGGGCTGTATGCCCAGCAAGCTGTTAATTGCAGCTGCAGATAGAGCGCATCACGCCAACCATTCAGAAGAATTTGGT
ATTGAAGGCCAAGCCATCATCAATGGCAAACAAGTCATGAAACGGGTGCAGTCAGAAAGAGATCGCTTCTCAAGCTTTGC
GCTTAAAAATGTCGAGAGTTGGGATGAGAATAATAAAATCTATGGCCGAGCTGTGTTCTTAGAAGATGGCCTGATCGAAG
CACATACCTCAACCGGCGAGACGCTATACATAAAGGCGGAGCATATTATTATTGCCACTGGCTCCAAACCTTTTGTACCA
GAAGGTTGGAAGCTAACTTTGGGCGATGCCCTTATCACCTCAGATACAATTTTTGAGCTACCCGATTTGCCAAAGTCGAT
GGCGGTCGTGGGTGCCGGTGCTATCGGCCTAGAGTTGGCACAAGCCATGAGCCGATTAGGCGTTGAGGTGGCTATTTTTA
ATCGCAGCGAAAATGTCGGCGGTATTAAAGATGAGATTGTCAATCAAAAAGCAATAGACTGCTTTTCAAAACAGCTGGAT
TTGCGTCTGGCCACCAACATCCAAAGCGTATCGCGTGATGACAGTGCCAATAGCGCTCAGGCCATCATTAACTACACCGA
TGCCCAAGGTAATAGCCAAATTTGGCAAGGTGAAAAAGTTCTGGTAGCTACTGGCCGCCACAATACGTTAGATACTTTCG
GCGTCGAGCACTTAGGGGTGCGTTTGGATGATAAAAATCGTCCGCAAGACATGGACACCATCACCGGCAGGATCAAAGAT
ACCAATGTTTATATCGTTGGCGATGCCAATGCTTATATGCCCTTATTGCATGTCTCAAGTAATGAAGGTTATTTATCTGG
CAAAGAGGTAGCGCTAAAGATCTCAGGGCTATCAGATAAAGTTAGTATGAGTGATGCCATTGAACACGACCCTGACAGTT
CAAAAAACAGCACTCTTTTAAATGATATTGCCCCTGATAAATCACAAACTGTCACCACCCCCATGTCGGTTATATTTACC
TCGCCTCAAATTATGTCGGTTGGACAGACTATAGATGAGATTGAAAAATCTGGCGAAGCTTATGTGGTGGGTGAGGTAAG
CTTTGACAATCAAGGTCGTAGCCGTGTGATGGGCGTGAACTGCGGATTATTACGTATTTATAGCGCTGCCAACACCGGTC
TTGTATTAGGCGCAAGTATGGTAGGGCCTGATGCTGAATATCTTGCCCATATTTTGGCGACCGCCATTACTAATAAAGTA
GATATTGATGGCTTACTAGACAGCCCCTTCTACCACCCCACGATACTTGAAGGCCTACGCACTGCACTGCGTGATGTCGC
CTCTAAGCTAAGAGCCTACCAAGCCTAG

Upstream 100 bases:

>100_bases
CTTGTTTAAGCACAATGCAGTCTTTATAAAAATCTAAGGTATTACCTGTGTTTGCGGCATAGCCTCCATAAATTATTTAT
AACCTAATACAAGGATTATC

Downstream 100 bases:

>100_bases
TATAATAAACACGTATTGTGCTGTTCATAAAGACACTCTAACTATAGGGTGTTTTTTTATAGCAGGGTATTTTGTATAGC
AGGATATTTTTATAGATAGT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTKPAIDSQKSIRYVDAAVIGAGTAGHNAYRQISKVTDNVVIINEGIWSTTCTTMGCMPSKLLIAAADRAHHANHSEEFG
IEGQAIINGKQVMKRVQSERDRFSSFALKNVESWDENNKIYGRAVFLEDGLIEAHTSTGETLYIKAEHIIIATGSKPFVP
EGWKLTLGDALITSDTIFELPDLPKSMAVVGAGAIGLELAQAMSRLGVEVAIFNRSENVGGIKDEIVNQKAIDCFSKQLD
LRLATNIQSVSRDDSANSAQAIINYTDAQGNSQIWQGEKVLVATGRHNTLDTFGVEHLGVRLDDKNRPQDMDTITGRIKD
TNVYIVGDANAYMPLLHVSSNEGYLSGKEVALKISGLSDKVSMSDAIEHDPDSSKNSTLLNDIAPDKSQTVTTPMSVIFT
SPQIMSVGQTIDEIEKSGEAYVVGEVSFDNQGRSRVMGVNCGLLRIYSAANTGLVLGASMVGPDAEYLAHILATAITNKV
DIDGLLDSPFYHPTILEGLRTALRDVASKLRAYQA

Sequences:

>Translated_515_residues
MTKPAIDSQKSIRYVDAAVIGAGTAGHNAYRQISKVTDNVVIINEGIWSTTCTTMGCMPSKLLIAAADRAHHANHSEEFG
IEGQAIINGKQVMKRVQSERDRFSSFALKNVESWDENNKIYGRAVFLEDGLIEAHTSTGETLYIKAEHIIIATGSKPFVP
EGWKLTLGDALITSDTIFELPDLPKSMAVVGAGAIGLELAQAMSRLGVEVAIFNRSENVGGIKDEIVNQKAIDCFSKQLD
LRLATNIQSVSRDDSANSAQAIINYTDAQGNSQIWQGEKVLVATGRHNTLDTFGVEHLGVRLDDKNRPQDMDTITGRIKD
TNVYIVGDANAYMPLLHVSSNEGYLSGKEVALKISGLSDKVSMSDAIEHDPDSSKNSTLLNDIAPDKSQTVTTPMSVIFT
SPQIMSVGQTIDEIEKSGEAYVVGEVSFDNQGRSRVMGVNCGLLRIYSAANTGLVLGASMVGPDAEYLAHILATAITNKV
DIDGLLDSPFYHPTILEGLRTALRDVASKLRAYQA
>Mature_514_residues
TKPAIDSQKSIRYVDAAVIGAGTAGHNAYRQISKVTDNVVIINEGIWSTTCTTMGCMPSKLLIAAADRAHHANHSEEFGI
EGQAIINGKQVMKRVQSERDRFSSFALKNVESWDENNKIYGRAVFLEDGLIEAHTSTGETLYIKAEHIIIATGSKPFVPE
GWKLTLGDALITSDTIFELPDLPKSMAVVGAGAIGLELAQAMSRLGVEVAIFNRSENVGGIKDEIVNQKAIDCFSKQLDL
RLATNIQSVSRDDSANSAQAIINYTDAQGNSQIWQGEKVLVATGRHNTLDTFGVEHLGVRLDDKNRPQDMDTITGRIKDT
NVYIVGDANAYMPLLHVSSNEGYLSGKEVALKISGLSDKVSMSDAIEHDPDSSKNSTLLNDIAPDKSQTVTTPMSVIFTS
PQIMSVGQTIDEIEKSGEAYVVGEVSFDNQGRSRVMGVNCGLLRIYSAANTGLVLGASMVGPDAEYLAHILATAITNKVD
IDGLLDSPFYHPTILEGLRTALRDVASKLRAYQA

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=498, Percent_Identity=24.2971887550201, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI291045268, Length=345, Percent_Identity=26.9565217391304, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI291045266, Length=345, Percent_Identity=26.9565217391304, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI50301238, Length=471, Percent_Identity=23.9915074309979, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI33519430, Length=296, Percent_Identity=23.9864864864865, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI33519428, Length=296, Percent_Identity=23.9864864864865, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI33519426, Length=296, Percent_Identity=23.9864864864865, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI148277065, Length=296, Percent_Identity=23.9864864864865, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI148277071, Length=296, Percent_Identity=23.9864864864865, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082354, Length=506, Percent_Identity=22.5296442687747, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786307, Length=503, Percent_Identity=22.6640159045726, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1789915, Length=370, Percent_Identity=25.4054054054054, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87081717, Length=496, Percent_Identity=22.9838709677419, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=494, Percent_Identity=23.8866396761134, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17557007, Length=504, Percent_Identity=23.4126984126984, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71983429, Length=283, Percent_Identity=24.3816254416961, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983419, Length=275, Percent_Identity=24.7272727272727, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=504, Percent_Identity=24.4047619047619, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=25.3191489361702, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6325240, Length=502, Percent_Identity=21.3147410358566, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358499, Length=501, Percent_Identity=25.1497005988024, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640549, Length=454, Percent_Identity=25.3303964757709, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640553, Length=454, Percent_Identity=25.3303964757709, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640551, Length=454, Percent_Identity=25.3303964757709, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737741, Length=502, Percent_Identity=24.3027888446215, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 55634; Mature: 55503

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPAIDSQKSIRYVDAAVIGAGTAGHNAYRQISKVTDNVVIINEGIWSTTCTTMGCMPS
CCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCC
KLLIAAADRAHHANHSEEFGIEGQAIINGKQVMKRVQSERDRFSSFALKNVESWDENNKI
CEEEEECCHHHCCCCCHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
YGRAVFLEDGLIEAHTSTGETLYIKAEHIIIATGSKPFVPEGWKLTLGDALITSDTIFEL
EEEEEEEECCEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCEEEECCEEECCCCEEEC
PDLPKSMAVVGAGAIGLELAQAMSRLGVEVAIFNRSENVGGIKDEIVNQKAIDCFSKQLD
CCCCCHHHHEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCHHHHHHHHHHCC
LRLATNIQSVSRDDSANSAQAIINYTDAQGNSQIWQGEKVLVATGRHNTLDTFGVEHLGV
EEEECCHHHHCCCCCCCCCEEEEEEECCCCCCCEECCCEEEEEECCCCCCHHCCHHHEEE
RLDDKNRPQDMDTITGRIKDTNVYIVGDANAYMPLLHVSSNEGYLSGKEVALKISGLSDK
EECCCCCCCCCHHHHCEEEECEEEEEECCCCEEEEEEEECCCCEECCCEEEEEEECCCCC
VSMSDAIEHDPDSSKNSTLLNDIAPDKSQTVTTPMSVIFTSPQIMSVGQTIDEIEKSGEA
CCHHHHHCCCCCCCCCCEEHHCCCCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHCCCE
YVVGEVSFDNQGRSRVMGVNCGLLRIYSAANTGLVLGASMVGPDAEYLAHILATAITNKV
EEEEEEEECCCCCCEEEECCCCEEEEEECCCCCEEEEEHHCCCCHHHHHHHHHHHHCCCC
DIDGLLDSPFYHPTILEGLRTALRDVASKLRAYQA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKPAIDSQKSIRYVDAAVIGAGTAGHNAYRQISKVTDNVVIINEGIWSTTCTTMGCMPS
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCC
KLLIAAADRAHHANHSEEFGIEGQAIINGKQVMKRVQSERDRFSSFALKNVESWDENNKI
CEEEEECCHHHCCCCCHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
YGRAVFLEDGLIEAHTSTGETLYIKAEHIIIATGSKPFVPEGWKLTLGDALITSDTIFEL
EEEEEEEECCEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCEEEECCEEECCCCEEEC
PDLPKSMAVVGAGAIGLELAQAMSRLGVEVAIFNRSENVGGIKDEIVNQKAIDCFSKQLD
CCCCCHHHHEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCHHHHHHHHHHCC
LRLATNIQSVSRDDSANSAQAIINYTDAQGNSQIWQGEKVLVATGRHNTLDTFGVEHLGV
EEEECCHHHHCCCCCCCCCEEEEEEECCCCCCCEECCCEEEEEECCCCCCHHCCHHHEEE
RLDDKNRPQDMDTITGRIKDTNVYIVGDANAYMPLLHVSSNEGYLSGKEVALKISGLSDK
EECCCCCCCCCHHHHCEEEECEEEEEECCCCEEEEEEEECCCCEECCCEEEEEEECCCCC
VSMSDAIEHDPDSSKNSTLLNDIAPDKSQTVTTPMSVIFTSPQIMSVGQTIDEIEKSGEA
CCHHHHHCCCCCCCCCCEEHHCCCCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHCCCE
YVVGEVSFDNQGRSRVMGVNCGLLRIYSAANTGLVLGASMVGPDAEYLAHILATAITNKV
EEEEEEEECCCCCCEEEECCCCEEEEEECCCCCEEEEEHHCCCCHHHHHHHHHHHHCCCC
DIDGLLDSPFYHPTILEGLRTALRDVASKLRAYQA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]