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The map label for this gene is kefC [H]

Identifier: 148653558

GI number: 148653558

Start: 2180373

End: 2182223

Strand: Direct

Name: kefC [H]

Synonym: PsycPRwf_1761

Alternate gene names: 148653558

Gene position: 2180373-2182223 (Clockwise)

Preceding gene: 148653557

Following gene: 148653560

Centisome position: 73.19

GC content: 47.65

Gene sequence:

>1851_bases
ATGATTGCAGCCTCCCTTGTTCAACCCAGTCTCATGTTACAAGCGACCATCTTTTTAGGTGCCGCCTTGTTATTGGTACC
TTTGGGCAAGCGGCTGCATATCTCAACTGTACTGGGTTATCTGATTACTGGCTTGCTGCTGGGTCCGAGTGTGTTTGATG
TGGCCGGTGATGCCGAAAGTTTAATGCACTTTTCTGAGTTTGGGGTGGTCATGCTGTTGTTCGTCATCGGACTTGAGCTG
CAGCCCTCACGGCTTTGGGCGCTGCGTCACTCGATTTTTGTATTCGGGGGCTTGCAAGTTGGGGTGACAGGCTTATTGTT
AATGGGGCTGCTGTATGAATTTAGCAGCTTAAAATTAGACACCGCCTTTATTGTCGGCTTTGGTCTGGCGTTGTCTTCTA
CTGCCTTTGTGCTACAAGTATTGACCGAAAAGGAGCAACTGTCGAGCACCCATGGCCGCGAAGCCTTTACCATCTTATTG
TTCCAAGACATCGCGGTTATTCCTCTGCTGGCTGCCATTCCCTTCTTATCTGGGGTGCGTGAGCAGACTTATGACTTAAT
TTATTTTGGTAAAGTGGTGGCAGTGTTTGGCGGCTTATTCTTAGTCAGCCGTTATGTTGTACGCCCTTTTTTCAAGTTCG
TGGCCTTAAGTGGTGCTAATGAGCTGCTGACCGCCGTGGCGCTATTTATTGTCATGGGCGTGTCTATTTTGATGGGGCAG
ATTGGCTTATCTATGGCATTGGGTGCTTTTTTGACCGGTGTACTACTGGCCGACTCTGAATACCGCCATGAGCTTGAAGC
CAGTATTGAGCCCTTTAAAGGCTTGCTGCTGGGTCTATTTTTTATGTCCGTTGGTATGCTCACCGACGTCAAACTTATCT
TGGCGCACCCCGCTTTTATCATTGGCGCAGCCATTGCCTTAATGGTGATTAAATTTGGGGTGATTACCATTATTGCCCGC
TTATTAGGCAACCGCTTACCAACCAGTATTCGTCTGGGGGTGACTTTGGCTCAAGGCGGTGAGTTTGCTTTTGTGTTATT
TAGCACGGCGGCCAATTCAAACGTACTGCGTCCAGAGCATGCCAATCTACTGACTTTGATTGTGACCATCTCTATGGCAC
TGACCCCTATTGGATTTATGCTGCTTGAAAAATTCGGTGAGCCCAGATTTGATAAAGGTCAGCCAGACCGTGAATATGAC
AGCATCCCTGACCATGAGCATCCGGTAATTATCGCAGGCTTTGGCCGTGTCGGACAAATTATCGGCCGCGTACTGCGCAT
GCATAATATCGAATTTACCGCCATTGAAAGCTCAGCCAACCAAGTGGATTTCGTGCGTAAGTTTGGTAACCAAGTTTATT
ATGGTAACCCGCAAAATCCGCAAATCTTGCGTACTGCCGGTATTGAGAAGGCACGCCTGTTTATCATCGCCATTGATGAT
ATCGAGCGCTCTATTGCCACTGCCCGCTACTTGCATACCAATTATCCGCATCTTCAAATCCTAGTACGTGCGCGTAACCG
GGCCCATTTTTACCGTTTGCGAGAGATTGGTATTACTCACATTTGGCGCGAAACCTACTTATCCTCGCTAGATATGTCAC
GTGAGTCGCTTGAGCTGCTTGGTATTTCTCCTCAAAAAGCGCGCGAGACCATCACCGCCTTTCGTGATTATGATGACAAA
CTGTTGGCACAGCAGCAGGCCATTTATGAAGATGAGGCCAAGATGATTGCCTCGGTACAGTCCTCTATGATGGAGCTTGA
AAGCTTATTTGATTCTGATCATTCAGAGGGCAAAAAGCTGGACTTAAATGAAATAGAAACCGCAGTGGGCATTCATAAAT
CCAGCTCTTAG

Upstream 100 bases:

>100_bases
AATAGTAACCATCACTGTTGTGACATACCTCTTTTATCACTTGTTTTATCACTTGCTTGCCCTAAGCTTACCGCCACTGC
TCTACAAATAAGGATCCTAC

Downstream 100 bases:

>100_bases
CAGGCCAGGTTGTCTGATTTTCAACTGGGTTTATTTAGCTGCTTTGACATATCGCAGGGCGCTGCTTGTCATTTAAAGTA
CTGATACATTGCCATTTGCC

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MIAASLVQPSLMLQATIFLGAALLLVPLGKRLHISTVLGYLITGLLLGPSVFDVAGDAESLMHFSEFGVVMLLFVIGLEL
QPSRLWALRHSIFVFGGLQVGVTGLLLMGLLYEFSSLKLDTAFIVGFGLALSSTAFVLQVLTEKEQLSSTHGREAFTILL
FQDIAVIPLLAAIPFLSGVREQTYDLIYFGKVVAVFGGLFLVSRYVVRPFFKFVALSGANELLTAVALFIVMGVSILMGQ
IGLSMALGAFLTGVLLADSEYRHELEASIEPFKGLLLGLFFMSVGMLTDVKLILAHPAFIIGAAIALMVIKFGVITIIAR
LLGNRLPTSIRLGVTLAQGGEFAFVLFSTAANSNVLRPEHANLLTLIVTISMALTPIGFMLLEKFGEPRFDKGQPDREYD
SIPDHEHPVIIAGFGRVGQIIGRVLRMHNIEFTAIESSANQVDFVRKFGNQVYYGNPQNPQILRTAGIEKARLFIIAIDD
IERSIATARYLHTNYPHLQILVRARNRAHFYRLREIGITHIWRETYLSSLDMSRESLELLGISPQKARETITAFRDYDDK
LLAQQQAIYEDEAKMIASVQSSMMELESLFDSDHSEGKKLDLNEIETAVGIHKSSS

Sequences:

>Translated_616_residues
MIAASLVQPSLMLQATIFLGAALLLVPLGKRLHISTVLGYLITGLLLGPSVFDVAGDAESLMHFSEFGVVMLLFVIGLEL
QPSRLWALRHSIFVFGGLQVGVTGLLLMGLLYEFSSLKLDTAFIVGFGLALSSTAFVLQVLTEKEQLSSTHGREAFTILL
FQDIAVIPLLAAIPFLSGVREQTYDLIYFGKVVAVFGGLFLVSRYVVRPFFKFVALSGANELLTAVALFIVMGVSILMGQ
IGLSMALGAFLTGVLLADSEYRHELEASIEPFKGLLLGLFFMSVGMLTDVKLILAHPAFIIGAAIALMVIKFGVITIIAR
LLGNRLPTSIRLGVTLAQGGEFAFVLFSTAANSNVLRPEHANLLTLIVTISMALTPIGFMLLEKFGEPRFDKGQPDREYD
SIPDHEHPVIIAGFGRVGQIIGRVLRMHNIEFTAIESSANQVDFVRKFGNQVYYGNPQNPQILRTAGIEKARLFIIAIDD
IERSIATARYLHTNYPHLQILVRARNRAHFYRLREIGITHIWRETYLSSLDMSRESLELLGISPQKARETITAFRDYDDK
LLAQQQAIYEDEAKMIASVQSSMMELESLFDSDHSEGKKLDLNEIETAVGIHKSSS
>Mature_616_residues
MIAASLVQPSLMLQATIFLGAALLLVPLGKRLHISTVLGYLITGLLLGPSVFDVAGDAESLMHFSEFGVVMLLFVIGLEL
QPSRLWALRHSIFVFGGLQVGVTGLLLMGLLYEFSSLKLDTAFIVGFGLALSSTAFVLQVLTEKEQLSSTHGREAFTILL
FQDIAVIPLLAAIPFLSGVREQTYDLIYFGKVVAVFGGLFLVSRYVVRPFFKFVALSGANELLTAVALFIVMGVSILMGQ
IGLSMALGAFLTGVLLADSEYRHELEASIEPFKGLLLGLFFMSVGMLTDVKLILAHPAFIIGAAIALMVIKFGVITIIAR
LLGNRLPTSIRLGVTLAQGGEFAFVLFSTAANSNVLRPEHANLLTLIVTISMALTPIGFMLLEKFGEPRFDKGQPDREYD
SIPDHEHPVIIAGFGRVGQIIGRVLRMHNIEFTAIESSANQVDFVRKFGNQVYYGNPQNPQILRTAGIEKARLFIIAIDD
IERSIATARYLHTNYPHLQILVRARNRAHFYRLREIGITHIWRETYLSSLDMSRESLELLGISPQKARETITAFRDYDDK
LLAQQQAIYEDEAKMIASVQSSMMELESLFDSDHSEGKKLDLNEIETAVGIHKSSS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=355, Percent_Identity=27.3239436619718, Blast_Score=88, Evalue=3e-17,
Organism=Escherichia coli, GI1786232, Length=573, Percent_Identity=43.979057591623, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI1789749, Length=597, Percent_Identity=40.3685092127303, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1786685, Length=556, Percent_Identity=30.0359712230216, Blast_Score=183, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67857; Mature: 67857

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAASLVQPSLMLQATIFLGAALLLVPLGKRLHISTVLGYLITGLLLGPSVFDVAGDAES
CCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHH
LMHFSEFGVVMLLFVIGLELQPSRLWALRHSIFVFGGLQVGVTGLLLMGLLYEFSSLKLD
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHCCCH
TAFIVGFGLALSSTAFVLQVLTEKEQLSSTHGREAFTILLFQDIAVIPLLAAIPFLSGVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHH
EQTYDLIYFGKVVAVFGGLFLVSRYVVRPFFKFVALSGANELLTAVALFIVMGVSILMGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IGLSMALGAFLTGVLLADSEYRHELEASIEPFKGLLLGLFFMSVGMLTDVKLILAHPAFI
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAAIALMVIKFGVITIIARLLGNRLPTSIRLGVTLAQGGEFAFVLFSTAANSNVLRPEH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCCH
ANLLTLIVTISMALTPIGFMLLEKFGEPRFDKGQPDREYDSIPDHEHPVIIAGFGRVGQI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHH
IGRVLRMHNIEFTAIESSANQVDFVRKFGNQVYYGNPQNPQILRTAGIEKARLFIIAIDD
HHHHHHHHCCEEEEECCCCHHHHHHHHHCCEEEECCCCCCCEEECCCCCEEEEEEEEECH
IERSIATARYLHTNYPHLQILVRARNRAHFYRLREIGITHIWRETYLSSLDMSRESLELL
HHHHHHHHHHHHCCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
GISPQKARETITAFRDYDDKLLAQQQAIYEDEAKMIASVQSSMMELESLFDSDHSEGKKL
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DLNEIETAVGIHKSSS
CHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIAASLVQPSLMLQATIFLGAALLLVPLGKRLHISTVLGYLITGLLLGPSVFDVAGDAES
CCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHH
LMHFSEFGVVMLLFVIGLELQPSRLWALRHSIFVFGGLQVGVTGLLLMGLLYEFSSLKLD
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHCCCH
TAFIVGFGLALSSTAFVLQVLTEKEQLSSTHGREAFTILLFQDIAVIPLLAAIPFLSGVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHH
EQTYDLIYFGKVVAVFGGLFLVSRYVVRPFFKFVALSGANELLTAVALFIVMGVSILMGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IGLSMALGAFLTGVLLADSEYRHELEASIEPFKGLLLGLFFMSVGMLTDVKLILAHPAFI
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAAIALMVIKFGVITIIARLLGNRLPTSIRLGVTLAQGGEFAFVLFSTAANSNVLRPEH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCCH
ANLLTLIVTISMALTPIGFMLLEKFGEPRFDKGQPDREYDSIPDHEHPVIIAGFGRVGQI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHH
IGRVLRMHNIEFTAIESSANQVDFVRKFGNQVYYGNPQNPQILRTAGIEKARLFIIAIDD
HHHHHHHHCCEEEEECCCCHHHHHHHHHCCEEEECCCCCCCEEECCCCCEEEEEEEEECH
IERSIATARYLHTNYPHLQILVRARNRAHFYRLREIGITHIWRETYLSSLDMSRESLELL
HHHHHHHHHHHHCCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
GISPQKARETITAFRDYDDKLLAQQQAIYEDEAKMIASVQSSMMELESLFDSDHSEGKKL
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DLNEIETAVGIHKSSS
CHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA