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The map label for this gene is lysC [H]

Identifier: 148653410

GI number: 148653410

Start: 1993766

End: 1995049

Strand: Direct

Name: lysC [H]

Synonym: PsycPRwf_1612

Alternate gene names: 148653410

Gene position: 1993766-1995049 (Clockwise)

Preceding gene: 148653409

Following gene: 148653411

Centisome position: 66.93

GC content: 46.26

Gene sequence:

>1284_bases
ATGGCATTGATTGTACAAAAATATGGTGGTACGTCGATGGGCAGTATCGACCGTATCAAGAATGTTGCAAAGCGGGTTAA
ACGCTGGCATGACCATGGGCATCAAGTAATTGTTGTCGTATCAGCCATGAGCGGTGAGACGAACCGTTTAATCGACCTGG
CCACTCAAATTAGTAAGTACCCTGATCCGCGTGAGTATGACCAAATGGTCTCAACGGGCGAGCAGGTATCCATCTCCTTA
TTGTCTATGGCAATCAAAGAGCTGGGTATCGGTGCACGCTCCTTTACTGGCGGTCAAGTGGCGATTAAAACTGATAATAA
GCACAATAAAGCACGCATTGAATCTATTGATGCCGAAAAAATTCAAGCACAGCTCGATGACGGCAATGTGGTCGTGGTAG
CAGGATTTCAGGGCATAGATGCCGAAGGCAATATCACCACCTTAGGTCGTGGCGGCTCAGACACCACAGGTGTTGCCCTA
GCGGCAGCGTTAGGCGCTGATGAATGCCAGATTTATACGGATGTAGATGGGGTGTATACCACCGATCCTCGCGTCACCTC
AAAAGCACGTAAGCTTGATAAGATTACGTTTGAAGAAATGCTAGAGATGGCGAGTCTGGGCTCAAAAGTTCTGCAAATTC
GTGCCGTTGAGTTTGCTGGTAAATACCAAGTACCTTTAAGAGTACTGTCGAGCTTCGATGAAGGTCAAGACGGTAGCTTT
GATGAAGAATTCCGCCAAAACGTTGGCACACTGATTACAGTAGACGAAGGAGACGACATGGAACAGCCGGTCATTTCAGG
CATCGCATTTAACAGAGATGAAGCAAAAATTGTGGTGCGCGGTGTGCCAGATCATCCAGGCATTGCCTCTGGTATCTTAA
CCCCCATTAGTAATGCCAATATCGAAATCGATATGATTTTGCAGAACCTATCCGATCAAGGCTTAACTGACTTTAGTTTT
ACTGTCAATCGTCCTGACTTTGACAAGGCCATTACTATCTTAGAGAGCATTAAAGGGGACATCGAGGCCAAAGAAATCCA
TGGCAATACCGATGTGGTCAAAGTCTCACTTGTGGGTGTTGGCATGCGCTCTCATGCCGGTGTGGCCAGTAAGATGTTCC
AAGTATTGGCCGAAAACAACATCAATATCCAGATGATCTCTACCAGTGAAATCAAGATCTCTGTATTGATTAAAGAGCAG
CATCTAGAAAAAGCGGTTAAATCATTACACACCGCCTTTGGCCTAGATCGTGCAGATGGCGAAAGCAAAGTTGCGGGTCT
GTAA

Upstream 100 bases:

>100_bases
AGGCATGCGGTACACTTTGGCCAGATAGAGTCGATATAAGTTGGCGCGATAGTAGTAGAGATAATGGGCAAAACCAAACT
TTCAATTCAAAGGGTTTCAC

Downstream 100 bases:

>100_bases
TTGCTAATATGTCATGACTAGCTTGTCATTGCTGACTATCTAGTGATACTGCTGTTTTTTATACACCAAAGCCGGCTTTA
ACTTAACAGTTAAAGCCGGC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MALIVQKYGGTSMGSIDRIKNVAKRVKRWHDHGHQVIVVVSAMSGETNRLIDLATQISKYPDPREYDQMVSTGEQVSISL
LSMAIKELGIGARSFTGGQVAIKTDNKHNKARIESIDAEKIQAQLDDGNVVVVAGFQGIDAEGNITTLGRGGSDTTGVAL
AAALGADECQIYTDVDGVYTTDPRVTSKARKLDKITFEEMLEMASLGSKVLQIRAVEFAGKYQVPLRVLSSFDEGQDGSF
DEEFRQNVGTLITVDEGDDMEQPVISGIAFNRDEAKIVVRGVPDHPGIASGILTPISNANIEIDMILQNLSDQGLTDFSF
TVNRPDFDKAITILESIKGDIEAKEIHGNTDVVKVSLVGVGMRSHAGVASKMFQVLAENNINIQMISTSEIKISVLIKEQ
HLEKAVKSLHTAFGLDRADGESKVAGL

Sequences:

>Translated_427_residues
MALIVQKYGGTSMGSIDRIKNVAKRVKRWHDHGHQVIVVVSAMSGETNRLIDLATQISKYPDPREYDQMVSTGEQVSISL
LSMAIKELGIGARSFTGGQVAIKTDNKHNKARIESIDAEKIQAQLDDGNVVVVAGFQGIDAEGNITTLGRGGSDTTGVAL
AAALGADECQIYTDVDGVYTTDPRVTSKARKLDKITFEEMLEMASLGSKVLQIRAVEFAGKYQVPLRVLSSFDEGQDGSF
DEEFRQNVGTLITVDEGDDMEQPVISGIAFNRDEAKIVVRGVPDHPGIASGILTPISNANIEIDMILQNLSDQGLTDFSF
TVNRPDFDKAITILESIKGDIEAKEIHGNTDVVKVSLVGVGMRSHAGVASKMFQVLAENNINIQMISTSEIKISVLIKEQ
HLEKAVKSLHTAFGLDRADGESKVAGL
>Mature_426_residues
ALIVQKYGGTSMGSIDRIKNVAKRVKRWHDHGHQVIVVVSAMSGETNRLIDLATQISKYPDPREYDQMVSTGEQVSISLL
SMAIKELGIGARSFTGGQVAIKTDNKHNKARIESIDAEKIQAQLDDGNVVVVAGFQGIDAEGNITTLGRGGSDTTGVALA
AALGADECQIYTDVDGVYTTDPRVTSKARKLDKITFEEMLEMASLGSKVLQIRAVEFAGKYQVPLRVLSSFDEGQDGSFD
EEFRQNVGTLITVDEGDDMEQPVISGIAFNRDEAKIVVRGVPDHPGIASGILTPISNANIEIDMILQNLSDQGLTDFSFT
VNRPDFDKAITILESIKGDIEAKEIHGNTDVVKVSLVGVGMRSHAGVASKMFQVLAENNINIQMISTSEIKISVLIKEQH
LEKAVKSLHTAFGLDRADGESKVAGL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=305, Percent_Identity=32.7868852459016, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1790455, Length=464, Percent_Identity=25.6465517241379, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790376, Length=364, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=507, Percent_Identity=25.2465483234714, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 46115; Mature: 45984

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKYGGTSMGSIDRIKNVAKRVKRWHDHGHQVIVVVSAMSGETNRLIDLATQISKY
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
PDPREYDQMVSTGEQVSISLLSMAIKELGIGARSFTGGQVAIKTDNKHNKARIESIDAEK
CCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHH
IQAQLDDGNVVVVAGFQGIDAEGNITTLGRGGSDTTGVALAAALGADECQIYTDVDGVYT
HHEEECCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVTSKARKLDKITFEEMLEMASLGSKVLQIRAVEFAGKYQVPLRVLSSFDEGQDGSF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHCCCCCCCCCC
DEEFRQNVGTLITVDEGDDMEQPVISGIAFNRDEAKIVVRGVPDHPGIASGILTPISNAN
HHHHHHCCCEEEEECCCCCCCHHHHHCEEECCCCCEEEEEECCCCCCCHHHHHCCCCCCC
IEIDMILQNLSDQGLTDFSFTVNRPDFDKAITILESIKGDIEAKEIHGNTDVVKVSLVGV
EEEEHEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEE
GMRSHAGVASKMFQVLAENNINIQMISTSEIKISVLIKEQHLEKAVKSLHTAFGLDRADG
CCHHCCHHHHHHHHHHHCCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCCC
ESKVAGL
CCCCCCC
>Mature Secondary Structure 
ALIVQKYGGTSMGSIDRIKNVAKRVKRWHDHGHQVIVVVSAMSGETNRLIDLATQISKY
EEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
PDPREYDQMVSTGEQVSISLLSMAIKELGIGARSFTGGQVAIKTDNKHNKARIESIDAEK
CCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHH
IQAQLDDGNVVVVAGFQGIDAEGNITTLGRGGSDTTGVALAAALGADECQIYTDVDGVYT
HHEEECCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVTSKARKLDKITFEEMLEMASLGSKVLQIRAVEFAGKYQVPLRVLSSFDEGQDGSF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHCCCCCCCCCC
DEEFRQNVGTLITVDEGDDMEQPVISGIAFNRDEAKIVVRGVPDHPGIASGILTPISNAN
HHHHHHCCCEEEEECCCCCCCHHHHHCEEECCCCCEEEEEECCCCCCCHHHHHCCCCCCC
IEIDMILQNLSDQGLTDFSFTVNRPDFDKAITILESIKGDIEAKEIHGNTDVVKVSLVGV
EEEEHEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEE
GMRSHAGVASKMFQVLAENNINIQMISTSEIKISVLIKEQHLEKAVKSLHTAFGLDRADG
CCHHCCHHHHHHHHHHHCCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCCC
ESKVAGL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]