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The map label for this gene is iclR [H]

Identifier: 148653332

GI number: 148653332

Start: 1876787

End: 1877566

Strand: Direct

Name: iclR [H]

Synonym: PsycPRwf_1534

Alternate gene names: 148653332

Gene position: 1876787-1877566 (Clockwise)

Preceding gene: 148653328

Following gene: 148653335

Centisome position: 63.0

GC content: 48.72

Gene sequence:

>780_bases
TTGAAAGACAATACCTCTAAGCCCTCTGTTAGCGTACCTGCCATAGATAAAATGTGCCTTATTTTGGATCTGATTACAGA
AGCCAATTACCCACTTACCTCAGCTGAAATCGCGTCGCAATTGTCACTTCCCAAAAGTAGCACCCACAATATCTTGCAAA
GTCTATTGGCCAAGCATTTGGTGTTTAAAGACCGTGACAACCGTTTTCATTTGGGGTCTTATCTGTTGTACTGGGCTGGC
AAGTATGAAAAGCAGCACAGTATTATTGATGTCTTTCACGAGGTCATTGTCAATCACCCCACGCTATTGCAGCACACGGT
GACCTTATCGAAGATTGATGGCAAGGAGGTGGTGTTTTTAGCCTGCCATGAGTCGCCAGCCCCACTAGGTTTTACCTTTC
GCTCAGGGGTGCGAGTGCCTGCGCCTTTTTCTGCCACTGGCAAAGCCATGTTATCCACTTATGACAATAGCACCATAACT
CAGCTGTTTGAGCAGCAGATGCCGGCGCCATATACCTCAAGAAGTGTGCAGCAATTGGATGTGCTACTTAAAGAGTTGCA
GCAGGTGCGTGATACCGGCATCTCACTTGATGATGGTCAGCTGCGAGAGGGTATGTATTGTCTGGGAACCTGTGTGGTCG
ATACGGAAGGACAGCCGATTGCTGGTATGGCCATCAGCTTCGTTAAAGAGGAGTATGAAAAACAGCGCGAGGGCGTCAGC
CAAGCCTTACTGGCCTTGGCCAAAGACATCTCCCAGCGCCTTGGCGTCAGCAGCCACTAA

Upstream 100 bases:

>100_bases
ATAACGACTCATCGTTACACACTTTCAATGACATATTGTCATGCCGCTCATTGAGCCAAGTAAGCTTGGATTACTTGAGT
ATTAAATAGGAAAATTCGAC

Downstream 100 bases:

>100_bases
TTCATTGCGCCAATAGCCAGCACTTATGTGTTGACAGGCATGGACGCAGATATTTTGTCTACACGATATTCTGAGCCCGC
AGCTGCTGTATCTTCTCATC

Product: regulatory protein IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKDNTSKPSVSVPAIDKMCLILDLITEANYPLTSAEIASQLSLPKSSTHNILQSLLAKHLVFKDRDNRFHLGSYLLYWAG
KYEKQHSIIDVFHEVIVNHPTLLQHTVTLSKIDGKEVVFLACHESPAPLGFTFRSGVRVPAPFSATGKAMLSTYDNSTIT
QLFEQQMPAPYTSRSVQQLDVLLKELQQVRDTGISLDDGQLREGMYCLGTCVVDTEGQPIAGMAISFVKEEYEKQREGVS
QALLALAKDISQRLGVSSH

Sequences:

>Translated_259_residues
MKDNTSKPSVSVPAIDKMCLILDLITEANYPLTSAEIASQLSLPKSSTHNILQSLLAKHLVFKDRDNRFHLGSYLLYWAG
KYEKQHSIIDVFHEVIVNHPTLLQHTVTLSKIDGKEVVFLACHESPAPLGFTFRSGVRVPAPFSATGKAMLSTYDNSTIT
QLFEQQMPAPYTSRSVQQLDVLLKELQQVRDTGISLDDGQLREGMYCLGTCVVDTEGQPIAGMAISFVKEEYEKQREGVS
QALLALAKDISQRLGVSSH
>Mature_259_residues
MKDNTSKPSVSVPAIDKMCLILDLITEANYPLTSAEIASQLSLPKSSTHNILQSLLAKHLVFKDRDNRFHLGSYLLYWAG
KYEKQHSIIDVFHEVIVNHPTLLQHTVTLSKIDGKEVVFLACHESPAPLGFTFRSGVRVPAPFSATGKAMLSTYDNSTIT
QLFEQQMPAPYTSRSVQQLDVLLKELQQVRDTGISLDDGQLREGMYCLGTCVVDTEGQPIAGMAISFVKEEYEKQREGVS
QALLALAKDISQRLGVSSH

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786715, Length=249, Percent_Identity=24.8995983935743, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082359, Length=225, Percent_Identity=22.6666666666667, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786468, Length=253, Percent_Identity=24.1106719367589, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788131, Length=249, Percent_Identity=25.3012048192771, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28693; Mature: 28693

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDNTSKPSVSVPAIDKMCLILDLITEANYPLTSAEIASQLSLPKSSTHNILQSLLAKHL
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
VFKDRDNRFHLGSYLLYWAGKYEKQHSIIDVFHEVIVNHPTLLQHTVTLSKIDGKEVVFL
HHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCEEEEE
ACHESPAPLGFTFRSGVRVPAPFSATGKAMLSTYDNSTITQLFEQQMPAPYTSRSVQQLD
EECCCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
VLLKELQQVRDTGISLDDGQLREGMYCLGTCVVDTEGQPIAGMAISFVKEEYEKQREGVS
HHHHHHHHHHHCCCCCCCCHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QALLALAKDISQRLGVSSH
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKDNTSKPSVSVPAIDKMCLILDLITEANYPLTSAEIASQLSLPKSSTHNILQSLLAKHL
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
VFKDRDNRFHLGSYLLYWAGKYEKQHSIIDVFHEVIVNHPTLLQHTVTLSKIDGKEVVFL
HHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCEEEEE
ACHESPAPLGFTFRSGVRVPAPFSATGKAMLSTYDNSTITQLFEQQMPAPYTSRSVQQLD
EECCCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
VLLKELQQVRDTGISLDDGQLREGMYCLGTCVVDTEGQPIAGMAISFVKEEYEKQREGVS
HHHHHHHHHHHCCCCCCCCHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QALLALAKDISQRLGVSSH
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]