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The map label for this gene is nadR [H]

Identifier: 148653261

GI number: 148653261

Start: 1789761

End: 1790345

Strand: Direct

Name: nadR [H]

Synonym: PsycPRwf_1459

Alternate gene names: 148653261

Gene position: 1789761-1790345 (Clockwise)

Preceding gene: 148653253

Following gene: 148653263

Centisome position: 60.08

GC content: 48.38

Gene sequence:

>585_bases
ATGCCTATTAAGGTATCACAAGCTCATTTAGAAGCCGAGTTACAGCAGCACACGCCAGCCGGTATTAAAAAGGTGCTTAT
CCTTGGTGCCGAAAGTACTGGCAAAACGACCCTATGCCAAGATTTGGCTCAGCATTATCAGACTCAGTGGGTAATTGAGT
ACATGCGCCCCTATTTGCAGCACAAATGGGACACCACTCAAAGCGTTTGTGAATGGCAGGATTTAATGCCGATTGCCTAT
GGGCAAGTTGCGACCGAAAATCAGCAGGCAGCGGTGGCCAATCGCTATCTGTTTTGTGATACCGCTTTATTTGAGATTAT
GGTGTATGCGTATTGGTATTATAATGAGTGTCCAGCCGCGCTTAAGGCTGCAGCACTGAGCCATCATTACGACTTGATCT
TGCTAACGCAGGTGGATGTGCCTTGGGTGGCTGATGACTTACGTGACGCGCCCCAGCAGCGAGAGCAGATTACCCAAGCG
TTTATCGATGCTTTAACTGAGCACAATAAGCCATTTTTACGCATTGGTGGGACACGTCAAGCACGGGTACAGCAAGTTAC
CCAGTGGCTTGACGCTGGTTTATGA

Upstream 100 bases:

>100_bases
TATCTTTTTCTATCTCAGCTTATTTATGGCGCAATTGATAACTATAAATTGCTATTGTTCAGTGTACAAGCGTTTATTAA
TATAAAAAGGTTATTTTAAA

Downstream 100 bases:

>100_bases
TAAGACAGCTTTTGGATAAGCTGCGACTATACCTTAATTTTCTGTAATACAAAGTCAATGTCTTTATCACCTCGACCGGA
CAAGTTGACCAAGATGCTCT

Product: NAD metabolism ATPase/kinase-like protein

Products: NA

Alternate protein names: Transcriptional regulator NadR; Nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase; NMN-AT; NMNAT; Nicotinamide ribonucleotide adenylyltransferase; Nicotinamide-nucleotide adenylyltransferase; Ribosylnicotinamide kinase; RNK; Nicotinamide riboside kinase; NRK; NmR-K [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MPIKVSQAHLEAELQQHTPAGIKKVLILGAESTGKTTLCQDLAQHYQTQWVIEYMRPYLQHKWDTTQSVCEWQDLMPIAY
GQVATENQQAAVANRYLFCDTALFEIMVYAYWYYNECPAALKAAALSHHYDLILLTQVDVPWVADDLRDAPQQREQITQA
FIDALTEHNKPFLRIGGTRQARVQQVTQWLDAGL

Sequences:

>Translated_194_residues
MPIKVSQAHLEAELQQHTPAGIKKVLILGAESTGKTTLCQDLAQHYQTQWVIEYMRPYLQHKWDTTQSVCEWQDLMPIAY
GQVATENQQAAVANRYLFCDTALFEIMVYAYWYYNECPAALKAAALSHHYDLILLTQVDVPWVADDLRDAPQQREQITQA
FIDALTEHNKPFLRIGGTRQARVQQVTQWLDAGL
>Mature_193_residues
PIKVSQAHLEAELQQHTPAGIKKVLILGAESTGKTTLCQDLAQHYQTQWVIEYMRPYLQHKWDTTQSVCEWQDLMPIAYG
QVATENQQAAVANRYLFCDTALFEIMVYAYWYYNECPAALKAAALSHHYDLILLTQVDVPWVADDLRDAPQQREQITQAF
IDALTEHNKPFLRIGGTRQARVQQVTQWLDAGL

Specific function: This enzyme has three activities:DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase

COG id: COG3172

COG function: function code H; Predicted ATPase/kinase involved in NAD metabolism

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein. Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH cro/C1-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082440, Length=159, Percent_Identity=28.3018867924528, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016429
- InterPro:   IPR004821
- InterPro:   IPR001387
- InterPro:   IPR010982
- InterPro:   IPR006417
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01381 HTH_3 [H]

EC number: =2.7.7.1; =2.7.1.22 [H]

Molecular weight: Translated: 22236; Mature: 22104

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKVSQAHLEAELQQHTPAGIKKVLILGAESTGKTTLCQDLAQHYQTQWVIEYMRPYLQ
CCCCCHHHHHHHHHHHCCCHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HKWDTTQSVCEWQDLMPIAYGQVATENQQAAVANRYLFCDTALFEIMVYAYWYYNECPAA
HCCCCHHHHHHHHHCCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
LKAAALSHHYDLILLTQVDVPWVADDLRDAPQQREQITQAFIDALTEHNKPFLRIGGTRQ
HHHHHHHCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHH
ARVQQVTQWLDAGL
HHHHHHHHHHHCCC
>Mature Secondary Structure 
PIKVSQAHLEAELQQHTPAGIKKVLILGAESTGKTTLCQDLAQHYQTQWVIEYMRPYLQ
CCCCHHHHHHHHHHHCCCHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HKWDTTQSVCEWQDLMPIAYGQVATENQQAAVANRYLFCDTALFEIMVYAYWYYNECPAA
HCCCCHHHHHHHHHCCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
LKAAALSHHYDLILLTQVDVPWVADDLRDAPQQREQITQAFIDALTEHNKPFLRIGGTRQ
HHHHHHHCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHH
ARVQQVTQWLDAGL
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 1327967 [H]