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The map label for this gene is purM [H]

Identifier: 148653242

GI number: 148653242

Start: 1764519

End: 1765610

Strand: Direct

Name: purM [H]

Synonym: PsycPRwf_1440

Alternate gene names: 148653242

Gene position: 1764519-1765610 (Clockwise)

Preceding gene: 148653235

Following gene: 148653243

Centisome position: 59.23

GC content: 47.99

Gene sequence:

>1092_bases
ATGAGCCATCCAAATTCTAATGCATCTGCTAACTCATCCACTCAAGATAAGCCCACTTCACTGAGCTACAAAGACGCTGG
TGTAGATATTGATGCAGGTGATGCCCTTGTACAACGCATTAAATCTGTTGCCAAGTCAACCACTCGCCCAGAAGTTGTCG
GCGGTTTGGGTGGTTTTGGCGCACTGTGCCGTATCCCTACAGGCTATAAGTCACCTTTATTGGTGTCAGGCACAGATGGT
GTGGGCACCAAGCTTAAGCTTGCCCTGCAATTAAATCGTCATGACACCATAGGTATCGACTTGGTGGCCATGTGTGTTAA
TGACCTATTGGTATGCGGTGCTGAGCCTTTATTCTTCTTAGACTACTATGCAACAGGTAAGCTTGACGTGGACACTGCTG
CGTCTGTGGTAGGCGGTATTGGTGAAGGCTGCAAACAGTCAAACTGTGCACTCATCGGTGGCGAGACGGCTGAAATGCCA
GGCATGTATCAAGACGAAGATTACGACTTGGCCGGTTTTTGTGTTGGCGTGGTAGAAGAGTCTGAGGTAATCACAGGAGA
TAACGTAGCAGCGGGCGATGTGATGATCGGTATTGCTTCAAGCGGTGCGCACTCAAATGGCTACTCACTCATTCGTAAAG
TCATTGAAGTCAGCGGTGTGGATATCGAAAACACCGATGAGACTGTAGACGGTAAGCCACTGGCTGACGCTCTGATGGCA
CCTACCAAAATCTATGTAAAATCTATCCAAGCACTACAAAAAGCACTGGGTAATAGTAAACTACATGCGATGTCACATAT
CACTGGTGGCGGCTTTACAGAGAACTTGCCTCGCGTACTGCCAGAGGCATTAGCCGCAAAAATCGATACTCAAAGCTGGC
AGATGCCTGAGCTATTTAACTGGCTACAACAACATGGCAATATCGAGCAATCTGAGATGTACCGCACCTTTAACTGCGGC
GTAGGCTTCGTGGTCGTCGTACCTGCAGATGTGGCCAATCAAGCCGTTGATATTTTAAATGACGCTGGCGAGAAAGCCTT
TATCTTTGGTGACATCATCGAGCGTACAGATGATGCTGTGGTTTACGCCTAA

Upstream 100 bases:

>100_bases
TGGTATTTGTCAAAATGCGCTGAGCAGATTGGTTAAACTGGTTATCCTACCTTCATATTTTTTTTATTCATACATTCGCT
TATTAAGGTCTGCTGCTACC

Downstream 100 bases:

>100_bases
TATGTCGGTATCTACTGTATCTACCAACCCCTTAAAAGTCGCCGTCTTAGTCTCAGGCAGTGGCAGCAATCTGCAAGTCC
TGATTGATGCCATGCAGGCC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSHPNSNASANSSTQDKPTSLSYKDAGVDIDAGDALVQRIKSVAKSTTRPEVVGGLGGFGALCRIPTGYKSPLLVSGTDG
VGTKLKLALQLNRHDTIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDTAASVVGGIGEGCKQSNCALIGGETAEMP
GMYQDEDYDLAGFCVGVVEESEVITGDNVAAGDVMIGIASSGAHSNGYSLIRKVIEVSGVDIENTDETVDGKPLADALMA
PTKIYVKSIQALQKALGNSKLHAMSHITGGGFTENLPRVLPEALAAKIDTQSWQMPELFNWLQQHGNIEQSEMYRTFNCG
VGFVVVVPADVANQAVDILNDAGEKAFIFGDIIERTDDAVVYA

Sequences:

>Translated_363_residues
MSHPNSNASANSSTQDKPTSLSYKDAGVDIDAGDALVQRIKSVAKSTTRPEVVGGLGGFGALCRIPTGYKSPLLVSGTDG
VGTKLKLALQLNRHDTIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDTAASVVGGIGEGCKQSNCALIGGETAEMP
GMYQDEDYDLAGFCVGVVEESEVITGDNVAAGDVMIGIASSGAHSNGYSLIRKVIEVSGVDIENTDETVDGKPLADALMA
PTKIYVKSIQALQKALGNSKLHAMSHITGGGFTENLPRVLPEALAAKIDTQSWQMPELFNWLQQHGNIEQSEMYRTFNCG
VGFVVVVPADVANQAVDILNDAGEKAFIFGDIIERTDDAVVYA
>Mature_362_residues
SHPNSNASANSSTQDKPTSLSYKDAGVDIDAGDALVQRIKSVAKSTTRPEVVGGLGGFGALCRIPTGYKSPLLVSGTDGV
GTKLKLALQLNRHDTIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDTAASVVGGIGEGCKQSNCALIGGETAEMPG
MYQDEDYDLAGFCVGVVEESEVITGDNVAAGDVMIGIASSGAHSNGYSLIRKVIEVSGVDIENTDETVDGKPLADALMAP
TKIYVKSIQALQKALGNSKLHAMSHITGGGFTENLPRVLPEALAAKIDTQSWQMPELFNWLQQHGNIEQSEMYRTFNCGV
GFVVVVPADVANQAVDILNDAGEKAFIFGDIIERTDDAVVYA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=347, Percent_Identity=49.2795389048991, Blast_Score=344, Evalue=7e-95,
Organism=Homo sapiens, GI209869995, Length=347, Percent_Identity=49.2795389048991, Blast_Score=344, Evalue=7e-95,
Organism=Homo sapiens, GI209869993, Length=347, Percent_Identity=49.2795389048991, Blast_Score=344, Evalue=7e-95,
Organism=Escherichia coli, GI1788845, Length=339, Percent_Identity=66.9616519174041, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17567511, Length=339, Percent_Identity=39.8230088495575, Blast_Score=237, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6321203, Length=355, Percent_Identity=44.7887323943662, Blast_Score=309, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24582400, Length=300, Percent_Identity=45, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38229; Mature: 38097

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPNSNASANSSTQDKPTSLSYKDAGVDIDAGDALVQRIKSVAKSTTRPEVVGGLGGFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCH
ALCRIPTGYKSPLLVSGTDGVGTKLKLALQLNRHDTIGIDLVAMCVNDLLVCGAEPLFFL
HHHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEE
DYYATGKLDVDTAASVVGGIGEGCKQSNCALIGGETAEMPGMYQDEDYDLAGFCVGVVEE
EEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHCCCCCCCCCCCCHHHEEEEEECC
SEVITGDNVAAGDVMIGIASSGAHSNGYSLIRKVIEVSGVDIENTDETVDGKPLADALMA
CCEECCCCCEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHC
PTKIYVKSIQALQKALGNSKLHAMSHITGGGFTENLPRVLPEALAAKIDTQSWQMPELFN
CHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
WLQQHGNIEQSEMYRTFNCGVGFVVVVPADVANQAVDILNDAGEKAFIFGDIIERTDDAV
HHHHHCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCE
VYA
EEC
>Mature Secondary Structure 
SHPNSNASANSSTQDKPTSLSYKDAGVDIDAGDALVQRIKSVAKSTTRPEVVGGLGGFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCH
ALCRIPTGYKSPLLVSGTDGVGTKLKLALQLNRHDTIGIDLVAMCVNDLLVCGAEPLFFL
HHHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEE
DYYATGKLDVDTAASVVGGIGEGCKQSNCALIGGETAEMPGMYQDEDYDLAGFCVGVVEE
EEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHCCCCCCCCCCCCHHHEEEEEECC
SEVITGDNVAAGDVMIGIASSGAHSNGYSLIRKVIEVSGVDIENTDETVDGKPLADALMA
CCEECCCCCEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHC
PTKIYVKSIQALQKALGNSKLHAMSHITGGGFTENLPRVLPEALAAKIDTQSWQMPELFN
CHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
WLQQHGNIEQSEMYRTFNCGVGFVVVVPADVANQAVDILNDAGEKAFIFGDIIERTDDAV
HHHHHCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCE
VYA
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA