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The map label for this gene is purD [H]

Identifier: 148653221

GI number: 148653221

Start: 1741876

End: 1743153

Strand: Direct

Name: purD [H]

Synonym: PsycPRwf_1419

Alternate gene names: 148653221

Gene position: 1741876-1743153 (Clockwise)

Preceding gene: 148653210

Following gene: 148653222

Centisome position: 58.47

GC content: 49.22

Gene sequence:

>1278_bases
ATGAATATTTTAATTATTGGTTCTGGTGGTCGTGAGCATGCACTGGCCTGGCAATGTGCAAAAGATGCCGATGTCACCAC
AGTCTATGTGGCCAATGGCAATGCTGGTACAGCCCTTGAATCAAAATGTGAAAATATTGACCTTGACACCACAGACCATC
AAGCGGTGATTTCTTTTTGTGGTCAACATAGCATTGAGCTTATTATTGTCGGCCCAGAAGCGCCTTTGGTCGCCGGCCTA
GTAGATGACTGCCGTAACGCAGGCATTGCCACTTGGGGACCTACTCAATACTGTGCCCAGCTTGAGGGCTCAAAAACTTT
TGCCAAAGAGTTCATGCAAGCGCATAACATCCCTACGGCCAAGTATGCGGCGTTTACAGACATTGAAGCCGCCAAAGCTT
ATGTTATCGACAATGGCGCACCTATCGTGGTCAAAGCCGATGGTCTTGCCGCCGGTAAAGGGGTAATTGTCGCTGAAACC
ATTGAACAAGCTCATGACGCCATTGAAGACATGCTGGGTGATAACAAGTTTGGTGATGCTGGTAGCCGCGTGGTTATCGA
GCAGTTCTTGCAAGGCGAAGAAGCCAGCTTTATTTGTATGATTGATGGCGAAAATATCCTACCTATGGCCACCAGTCAAG
ACCACAAACGTGTGGGTGAAGGTGATACGGGCCCGAACACCGGCGGTATGGGTGCGTACTCACCTGCTCCTGTGGTCACA
GATGAGGTGCATCAAAAGGTCATAAGCCAAGTGATCGAGCCTGTGGTGCACGCTATGAAAGCTGCCGGTCACCCTTACAC
TGGGTTTTTGTACGCTGGTCTTATGATTGATGACAACAATGACCCTTACGTGATTGAATTTAACTGCCGCTTTGGTGACC
CAGAAACTCAGCCCATCTTAATGCGTCTAAAAAGCTCATTAGTCAAACTGGTTCAACAAGGCGTTGAGGGTAAGCTACCT
GCGACTGCTGAATGGGACAGCCGCGCCGCTTTAGGCATTGTACTGGCCTCAAAAGGTTATCCTGAATCCTCATCAAAAGA
TGATGTGATTACGGGTCTGCCTGCTTTGAACGAAGATAACAGCGTTAAAGTCTTCCACGCCGGCACCAAGCAAAACGGCG
AACATGTGGTGACCAATGGAGGGCGTGTACTATGTGTGACGGCGCTAGGCGATACTATTAGCGAGGCGCAACAAGCCGCT
TTAGCGACCATAGCGACTATCGAATTTGAAGGGGCGCATTATCGCCGCGATATCGGATATAGAGCCATTAACCGCTAA

Upstream 100 bases:

>100_bases
CTTGTTGCAGCCTTAGCCTTCAACAACCTCCCATAACACACTGATTGATCAGCATCCATAATGATCAACATACACAATAT
AAAGCAAACAAGGGTTTTTT

Downstream 100 bases:

>100_bases
TCAATCTTAGATAAAAAGTAGTCACAAATAGGCTAACGCTGTGACTCAGATAACACTTAGGGCCACTGACTTTGGGATTG
TAATTGTAACCAAAACTGAA

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNILIIGSGGREHALAWQCAKDADVTTVYVANGNAGTALESKCENIDLDTTDHQAVISFCGQHSIELIIVGPEAPLVAGL
VDDCRNAGIATWGPTQYCAQLEGSKTFAKEFMQAHNIPTAKYAAFTDIEAAKAYVIDNGAPIVVKADGLAAGKGVIVAET
IEQAHDAIEDMLGDNKFGDAGSRVVIEQFLQGEEASFICMIDGENILPMATSQDHKRVGEGDTGPNTGGMGAYSPAPVVT
DEVHQKVISQVIEPVVHAMKAAGHPYTGFLYAGLMIDDNNDPYVIEFNCRFGDPETQPILMRLKSSLVKLVQQGVEGKLP
ATAEWDSRAALGIVLASKGYPESSSKDDVITGLPALNEDNSVKVFHAGTKQNGEHVVTNGGRVLCVTALGDTISEAQQAA
LATIATIEFEGAHYRRDIGYRAINR

Sequences:

>Translated_425_residues
MNILIIGSGGREHALAWQCAKDADVTTVYVANGNAGTALESKCENIDLDTTDHQAVISFCGQHSIELIIVGPEAPLVAGL
VDDCRNAGIATWGPTQYCAQLEGSKTFAKEFMQAHNIPTAKYAAFTDIEAAKAYVIDNGAPIVVKADGLAAGKGVIVAET
IEQAHDAIEDMLGDNKFGDAGSRVVIEQFLQGEEASFICMIDGENILPMATSQDHKRVGEGDTGPNTGGMGAYSPAPVVT
DEVHQKVISQVIEPVVHAMKAAGHPYTGFLYAGLMIDDNNDPYVIEFNCRFGDPETQPILMRLKSSLVKLVQQGVEGKLP
ATAEWDSRAALGIVLASKGYPESSSKDDVITGLPALNEDNSVKVFHAGTKQNGEHVVTNGGRVLCVTALGDTISEAQQAA
LATIATIEFEGAHYRRDIGYRAINR
>Mature_425_residues
MNILIIGSGGREHALAWQCAKDADVTTVYVANGNAGTALESKCENIDLDTTDHQAVISFCGQHSIELIIVGPEAPLVAGL
VDDCRNAGIATWGPTQYCAQLEGSKTFAKEFMQAHNIPTAKYAAFTDIEAAKAYVIDNGAPIVVKADGLAAGKGVIVAET
IEQAHDAIEDMLGDNKFGDAGSRVVIEQFLQGEEASFICMIDGENILPMATSQDHKRVGEGDTGPNTGGMGAYSPAPVVT
DEVHQKVISQVIEPVVHAMKAAGHPYTGFLYAGLMIDDNNDPYVIEFNCRFGDPETQPILMRLKSSLVKLVQQGVEGKLP
ATAEWDSRAALGIVLASKGYPESSSKDDVITGLPALNEDNSVKVFHAGTKQNGEHVVTNGGRVLCVTALGDTISEAQQAA
LATIATIEFEGAHYRRDIGYRAINR

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=425, Percent_Identity=50.1176470588235, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI209869995, Length=425, Percent_Identity=50.1176470588235, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI209869993, Length=425, Percent_Identity=50.1176470588235, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI28416899, Length=425, Percent_Identity=50.1176470588235, Blast_Score=411, Evalue=1e-115,
Organism=Escherichia coli, GI1790438, Length=427, Percent_Identity=61.5925058548009, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17567511, Length=426, Percent_Identity=41.5492957746479, Blast_Score=304, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6321203, Length=443, Percent_Identity=39.9548532731377, Blast_Score=323, Evalue=5e-89,
Organism=Drosophila melanogaster, GI62471619, Length=432, Percent_Identity=44.9074074074074, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24582400, Length=432, Percent_Identity=44.9074074074074, Blast_Score=342, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 45156; Mature: 45156

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIIGSGGREHALAWQCAKDADVTTVYVANGNAGTALESKCENIDLDTTDHQAVISFC
CEEEEEECCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHC
GQHSIELIIVGPEAPLVAGLVDDCRNAGIATWGPTQYCAQLEGSKTFAKEFMQAHNIPTA
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCH
KYAAFTDIEAAKAYVIDNGAPIVVKADGLAAGKGVIVAETIEQAHDAIEDMLGDNKFGDA
HHEEECCCCCCEEEEEECCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCC
GSRVVIEQFLQGEEASFICMIDGENILPMATSQDHKRVGEGDTGPNTGGMGAYSPAPVVT
CCHHHHHHHHCCCCCCEEEEECCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCH
DEVHQKVISQVIEPVVHAMKAAGHPYTGFLYAGLMIDDNNDPYVIEFNCRFGDPETQPIL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCCCHHH
MRLKSSLVKLVQQGVEGKLPATAEWDSRAALGIVLASKGYPESSSKDDVITGLPALNEDN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCC
SVKVFHAGTKQNGEHVVTNGGRVLCVTALGDTISEAQQAALATIATIEFEGAHYRRDIGY
CEEEEECCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHEEEEEEECCCHHHHHCCH
RAINR
HHCCC
>Mature Secondary Structure
MNILIIGSGGREHALAWQCAKDADVTTVYVANGNAGTALESKCENIDLDTTDHQAVISFC
CEEEEEECCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHC
GQHSIELIIVGPEAPLVAGLVDDCRNAGIATWGPTQYCAQLEGSKTFAKEFMQAHNIPTA
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCH
KYAAFTDIEAAKAYVIDNGAPIVVKADGLAAGKGVIVAETIEQAHDAIEDMLGDNKFGDA
HHEEECCCCCCEEEEEECCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCC
GSRVVIEQFLQGEEASFICMIDGENILPMATSQDHKRVGEGDTGPNTGGMGAYSPAPVVT
CCHHHHHHHHCCCCCCEEEEECCCCEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCH
DEVHQKVISQVIEPVVHAMKAAGHPYTGFLYAGLMIDDNNDPYVIEFNCRFGDPETQPIL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCCCHHH
MRLKSSLVKLVQQGVEGKLPATAEWDSRAALGIVLASKGYPESSSKDDVITGLPALNEDN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCC
SVKVFHAGTKQNGEHVVTNGGRVLCVTALGDTISEAQQAALATIATIEFEGAHYRRDIGY
CEEEEECCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHEEEEEEECCCHHHHHCCH
RAINR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]