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The map label for this gene is fadI [H]

Identifier: 148653192

GI number: 148653192

Start: 1705218

End: 1707044

Strand: Direct

Name: fadI [H]

Synonym: PsycPRwf_1390

Alternate gene names: 148653192

Gene position: 1705218-1707044 (Clockwise)

Preceding gene: 148653187

Following gene: 148653201

Centisome position: 57.24

GC content: 46.8

Gene sequence:

>1827_bases
ATGAGTAATTCTAATCAATCAAATAAATCTGCTGACAAATCCTCTGCGGTGACATCCACTGTGGTGAACAAAGCGGGTGA
GTCATTACTAAACGATACTAACAATGCCGCCCCGACCAAAGACTCAAACACCACATCAGACTTCTCAAAATTACAGCAAG
AAGTCGTCTCCACCTCAAAAACTGAGGCAGATACCGTCATCAGCGAAGATCGCGCTGCCAAACAAAAGATTATTGCCGAA
GCCAAAGCACAAGCACAACAAGAAGACAATCTGTCTCAAATCGATGAGCCTGCGCAAGAAGCCACACAAGTTAAAGACAA
TAAAGCTGACGACGCTCAAACTCAAAAAGAGTCTAATCAAACTGAATCTAAACAAGCGCAAGAACAAGCCACCAAATCTA
CTGCTGAAGCGCCCAAGCAAGAAGCTTCAGACAGCACCAATCAAACCCAAAAACAGTCTGGTGATAAGCCCGCTAACCAA
TCACCTGCTGATAAGTCAAAAACCAACAAGGAAAGCTCAATGTCAGACAATTCAAAAACCTCGAATCTTCCTCGCCGCGT
CGCTATTTTAGGCGGTAACCGTATTCCATTTGCACGCTCTAATGGTCCCTATGCTGACGCCAGCAACATTGACATGTTAA
GCGCCGCTTTAAACGGTCTGGTTGAGCGTTATGAATTACAAGGTGAGCGTGTTGGTGAAGTCGTGGCCGGTGCGGTATTA
AAACTAAGCCGTGACTTAAACCTAACCCGTGAGTCAGCGCTTAATACCGCTCTTGACCCACAAACGCCTGCCTATGATGT
CTCTCAAGCCTGTGGCACTGGTTTACAAGCCACTTTTGCTGCCAGCAATAAAATTGCTCTAGGCATTATCGATTCGGCCA
TTACTGGTGGTGTGGACACCACTTCAGATGCCCCTATTGCTGTGGGTGATGGTCTACGCAAAGCCTTAATCAAACTGGGC
GCCGCTCGCAATAACAAACAGCGCCTAAGCGCCCTAACCAGCATCAATCCAAAAGAGCTTATCGATGCGCCGCAAAATGG
TGAGCCACGTACCGGTCTATCTATGGGTGATCACCAGGCCATTACCGCTTTAGAATGGAACATCAGCCGTGAAGCACAAG
ATGAGTTGGCAGTAAAAAGCCATCAAAACCTAGCCCGTGCTTATGAAGAGGGCTTCTTTGATGACCTAATTACCCCATAC
AAGGGCTTAACCCGTGATAACAACTTACGTCCAGACTCTTCACTAGAAAAATTAGCGACGCTAAAACCTGTATTTGGTAA
ACGTAACGCTAACCCAACCATGACAGCAGCCAACTCTACCCCTCTAACCGATGGTGCTTCTTGTGTCCTACTGGGTACAG
ATGAGTGGGCTGAAGCTCATGGCCTAAAACCACTGGCTTATATTGTCCATCAAGAAACTGCTGCTGTTGATTTTATTGGC
AAAAATGGCCCTAAAGAAGGTCTGTTAATGGCACCTGCTTACGCTGTACCTCGTATGCTTGCACGTGCTGGCCTAACTTT
ACAAGACTTTGACTTCTATGAAATCCATGAAGCCTTCGCCTCACAAGTGCTGTCGACTCTAGCCGCCTGGGAAGATGAGA
CTTTCTGTAAGGAGCGTTTGGGTCTTGATGCCCCACTAGGATCTATTGACCGCAGTAAACTAAACGTTAATGGCTCATCA
CTGGCTGCAGGCCATCCATTTGCAGCAACCGGTGGTCGTATCCTAGCCACTGCTGCTAAGTTACTGGATCAAAAAGGGTC
AGGCCGTGCACTGATTTCAATCTGTGCAGCAGGTGGTCAAGGTGTCACTTGTATTTTAGAAAAATAA

Upstream 100 bases:

>100_bases
AAAGCAAACAGGCCCTGCAAATGACCGTCTTTGACTCTCATTGGGTGGCTTTTAAATAAAACTTTTGGTAAATAAAACTT
TTGGAATATAAGGACGTTAA

Downstream 100 bases:

>100_bases
GCCCTTAGCTATTTTAATGAACCTTAGCTATTTTAATAAAGATAAAATAAGTTAAGCACAGCTAAAAAAAAGAGCCTCGG
TGATGAATCGAGGCTCTTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSNSNQSNKSADKSSAVTSTVVNKAGESLLNDTNNAAPTKDSNTTSDFSKLQQEVVSTSKTEADTVISEDRAAKQKIIAE
AKAQAQQEDNLSQIDEPAQEATQVKDNKADDAQTQKESNQTESKQAQEQATKSTAEAPKQEASDSTNQTQKQSGDKPANQ
SPADKSKTNKESSMSDNSKTSNLPRRVAILGGNRIPFARSNGPYADASNIDMLSAALNGLVERYELQGERVGEVVAGAVL
KLSRDLNLTRESALNTALDPQTPAYDVSQACGTGLQATFAASNKIALGIIDSAITGGVDTTSDAPIAVGDGLRKALIKLG
AARNNKQRLSALTSINPKELIDAPQNGEPRTGLSMGDHQAITALEWNISREAQDELAVKSHQNLARAYEEGFFDDLITPY
KGLTRDNNLRPDSSLEKLATLKPVFGKRNANPTMTAANSTPLTDGASCVLLGTDEWAEAHGLKPLAYIVHQETAAVDFIG
KNGPKEGLLMAPAYAVPRMLARAGLTLQDFDFYEIHEAFASQVLSTLAAWEDETFCKERLGLDAPLGSIDRSKLNVNGSS
LAAGHPFAATGGRILATAAKLLDQKGSGRALISICAAGGQGVTCILEK

Sequences:

>Translated_608_residues
MSNSNQSNKSADKSSAVTSTVVNKAGESLLNDTNNAAPTKDSNTTSDFSKLQQEVVSTSKTEADTVISEDRAAKQKIIAE
AKAQAQQEDNLSQIDEPAQEATQVKDNKADDAQTQKESNQTESKQAQEQATKSTAEAPKQEASDSTNQTQKQSGDKPANQ
SPADKSKTNKESSMSDNSKTSNLPRRVAILGGNRIPFARSNGPYADASNIDMLSAALNGLVERYELQGERVGEVVAGAVL
KLSRDLNLTRESALNTALDPQTPAYDVSQACGTGLQATFAASNKIALGIIDSAITGGVDTTSDAPIAVGDGLRKALIKLG
AARNNKQRLSALTSINPKELIDAPQNGEPRTGLSMGDHQAITALEWNISREAQDELAVKSHQNLARAYEEGFFDDLITPY
KGLTRDNNLRPDSSLEKLATLKPVFGKRNANPTMTAANSTPLTDGASCVLLGTDEWAEAHGLKPLAYIVHQETAAVDFIG
KNGPKEGLLMAPAYAVPRMLARAGLTLQDFDFYEIHEAFASQVLSTLAAWEDETFCKERLGLDAPLGSIDRSKLNVNGSS
LAAGHPFAATGGRILATAAKLLDQKGSGRALISICAAGGQGVTCILEK
>Mature_607_residues
SNSNQSNKSADKSSAVTSTVVNKAGESLLNDTNNAAPTKDSNTTSDFSKLQQEVVSTSKTEADTVISEDRAAKQKIIAEA
KAQAQQEDNLSQIDEPAQEATQVKDNKADDAQTQKESNQTESKQAQEQATKSTAEAPKQEASDSTNQTQKQSGDKPANQS
PADKSKTNKESSMSDNSKTSNLPRRVAILGGNRIPFARSNGPYADASNIDMLSAALNGLVERYELQGERVGEVVAGAVLK
LSRDLNLTRESALNTALDPQTPAYDVSQACGTGLQATFAASNKIALGIIDSAITGGVDTTSDAPIAVGDGLRKALIKLGA
ARNNKQRLSALTSINPKELIDAPQNGEPRTGLSMGDHQAITALEWNISREAQDELAVKSHQNLARAYEEGFFDDLITPYK
GLTRDNNLRPDSSLEKLATLKPVFGKRNANPTMTAANSTPLTDGASCVLLGTDEWAEAHGLKPLAYIVHQETAAVDFIGK
NGPKEGLLMAPAYAVPRMLARAGLTLQDFDFYEIHEAFASQVLSTLAAWEDETFCKERLGLDAPLGSIDRSKLNVNGSSL
AAGHPFAATGGRILATAAKLLDQKGSGRALISICAAGGQGVTCILEK

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=37.995337995338, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI167614485, Length=438, Percent_Identity=29.2237442922374, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI148539872, Length=433, Percent_Identity=30.0230946882217, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI4501853, Length=436, Percent_Identity=28.6697247706422, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4557237, Length=440, Percent_Identity=27.9545454545455, Blast_Score=138, Evalue=2e-32,
Organism=Escherichia coli, GI1788683, Length=429, Percent_Identity=38.4615384615385, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1788554, Length=439, Percent_Identity=29.8405466970387, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082165, Length=438, Percent_Identity=30.5936073059361, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1787663, Length=441, Percent_Identity=31.2925170068027, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI48994986, Length=436, Percent_Identity=27.7522935779816, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17551802, Length=434, Percent_Identity=37.0967741935484, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI133906874, Length=432, Percent_Identity=28.4722222222222, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17535921, Length=433, Percent_Identity=27.9445727482679, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=435, Percent_Identity=26.8965517241379, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=457, Percent_Identity=29.9781181619256, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=445, Percent_Identity=27.6404494382022, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=37.4418604651163, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24655093, Length=430, Percent_Identity=30.2325581395349, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=31.8066157760814, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24640423, Length=434, Percent_Identity=26.4976958525346, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 64443; Mature: 64312

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSNQSNKSADKSSAVTSTVVNKAGESLLNDTNNAAPTKDSNTTSDFSKLQQEVVSTSK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
TEADTVISEDRAAKQKIIAEAKAQAQQEDNLSQIDEPAQEATQVKDNKADDAQTQKESNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TESKQAQEQATKSTAEAPKQEASDSTNQTQKQSGDKPANQSPADKSKTNKESSMSDNSKT
HHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCCCCCHHHCCCHHCCCCCCHH
SNLPRRVAILGGNRIPFARSNGPYADASNIDMLSAALNGLVERYELQGERVGEVVAGAVL
CCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KLSRDLNLTRESALNTALDPQTPAYDVSQACGTGLQATFAASNKIALGIIDSAITGGVDT
HHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCCEEEEEHHHHHCCCCCC
TSDAPIAVGDGLRKALIKLGAARNNKQRLSALTSINPKELIDAPQNGEPRTGLSMGDHQA
CCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCE
ITALEWNISREAQDELAVKSHQNLARAYEEGFFDDLITPYKGLTRDNNLRPDSSLEKLAT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LKPVFGKRNANPTMTAANSTPLTDGASCVLLGTDEWAEAHGLKPLAYIVHQETAAVDFIG
HHHHHCCCCCCCCEEECCCCCCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHEEECC
KNGPKEGLLMAPAYAVPRMLARAGLTLQDFDFYEIHEAFASQVLSTLAAWEDETFCKERL
CCCCCCCEEECCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GLDAPLGSIDRSKLNVNGSSLAAGHPFAATGGRILATAAKLLDQKGSGRALISICAAGGQ
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
GVTCILEK
CEEEEECC
>Mature Secondary Structure 
SNSNQSNKSADKSSAVTSTVVNKAGESLLNDTNNAAPTKDSNTTSDFSKLQQEVVSTSK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
TEADTVISEDRAAKQKIIAEAKAQAQQEDNLSQIDEPAQEATQVKDNKADDAQTQKESNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TESKQAQEQATKSTAEAPKQEASDSTNQTQKQSGDKPANQSPADKSKTNKESSMSDNSKT
HHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCCCCCHHHCCCHHCCCCCCHH
SNLPRRVAILGGNRIPFARSNGPYADASNIDMLSAALNGLVERYELQGERVGEVVAGAVL
CCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KLSRDLNLTRESALNTALDPQTPAYDVSQACGTGLQATFAASNKIALGIIDSAITGGVDT
HHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCCEEEEEHHHHHCCCCCC
TSDAPIAVGDGLRKALIKLGAARNNKQRLSALTSINPKELIDAPQNGEPRTGLSMGDHQA
CCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCE
ITALEWNISREAQDELAVKSHQNLARAYEEGFFDDLITPYKGLTRDNNLRPDSSLEKLAT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LKPVFGKRNANPTMTAANSTPLTDGASCVLLGTDEWAEAHGLKPLAYIVHQETAAVDFIG
HHHHHCCCCCCCCEEECCCCCCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHEEECC
KNGPKEGLLMAPAYAVPRMLARAGLTLQDFDFYEIHEAFASQVLSTLAAWEDETFCKERL
CCCCCCCEEECCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
GLDAPLGSIDRSKLNVNGSSLAAGHPFAATGGRILATAAKLLDQKGSGRALISICAAGGQ
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
GVTCILEK
CEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA