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The map label for this gene is cls [H]

Identifier: 148652920

GI number: 148652920

Start: 1367055

End: 1368491

Strand: Direct

Name: cls [H]

Synonym: PsycPRwf_1113

Alternate gene names: 148652920

Gene position: 1367055-1368491 (Clockwise)

Preceding gene: 148652919

Following gene: 148652924

Centisome position: 45.89

GC content: 51.64

Gene sequence:

>1437_bases
ATGTTTTTGGATTTTTTACTCGGCCTACATTTTTTGATATGGCTTACCATCTCGCTGCGGGTATTGGCCCGCCATGATCT
GTCCGCTCCGGCTCGTCTGGCTTGGCTGGTGGTGCTGTTTATCTTGCCATACGTAGGCGTGGTGGTGTATTGGATGTTTG
GTGAGGTGCATTTAGGTATTAACTTCACCCACCGCTATGATCGCATCACTCAGAAGCTGGCCGAAAGCTATCCTCAAGTG
CTGGGCGATAAAGACACGATGGCACAGGTGGTAGAGCGTGAATATCAAGCGGCCGGATATGCGGCGAGTGTCACCGGCTT
TCACACCACATTGGGCAACCGTGCCGAGCTTATGGCCGATGCCAAGGCCACGCAGCAGCGTATGATTGCCGACTTCGATG
CCGCCACAGATCACATTCACGTGATGTATTATATTTGGCTAGATGATGACATGGGGACCGCCGTGGGTGAGGCATTAATG
CGTGCTGCCAAACGCGGGGTGCGCTGCCGTGCCATGGTCGATGGCTTAGGGTCACGCAAGCTGTTACGCTCCTTATTGTG
GAAGCGGATGCAAGATGCTGGGGTTGAGGTGAGTGTGGCGCTACCGATCAATAACTTGCTAAAAGTGCTGCTGTTTAGTC
GTATTGACCTACGCAATCACCGTAAGATTACCGTGATTGATGGCAAGATTGGCTATGTCGGCAGCCGCAACAGTGCTGAT
CCTGAGTTTCGGATTAAGCCCAAGTATGCGCCCTGGGTCGATATCATGCTGCGGGTACAAGGCCCGCTGGTTGCCCAAAA
TCAGATGCTCTTTGCCAATGACTGGCTGATGGAAAACCCCGATACCGATTTTAACAGCTTCCCTTATGTCACCGAGCCGC
ATCCTGAGGGCATTGCCGCTCAAGTCTTCGCCGATGGTCCTACTCAGCGTCAAGGCACCACGCCGCAGTTTTTGAGTACG
CTGATGAGTCAGGCACGTCACACCCTTATCATCTCCACTCCCTATTTTGTCCCAGATTACACCTTGATTAATATGCTGTG
TGCCACCGCTTACCGCGGTGTGGCGGTGAGCATTATCTTTCCAAAGAACAACGACTCCTTTATTGTGGCCGCTACCAGTC
ACAGCTACTATTGGCAGCTGCTTGAAGCCGGCGTGAAGGTGTATGAGTATAAGCCTGGCTTACTGCATGCCAAGACTCTA
ACGGTGGATGGTAAGATCAGTCTAATTGGCTCGACCAATTTAGACCTGCGCAGCTTCGACTTAAACTATGAGAACAATGC
GTTATTTTATGATGAAGCGCTCACGGCAAAGATTGTGGAGCGTCAGTATGCGTATATCGCTGACTCAGATGAGGTGATGC
GTCAAGAGGTGCGTGACTGGCCGATTTATTACCGCATCTGGATTAATATTGTCTCCACCATGGGGCCGCTGCTCTAG

Upstream 100 bases:

>100_bases
AATGACAAGTGATCACCGCTTAGCTTTTAGAGTAGGGCTTTACTATCAACCACTATAATAAGAAGCACCCTTGTATTTTT
TATACTTAGAGAGTGACGGC

Downstream 100 bases:

>100_bases
ACAAACACCGTTACCAAGGGTAAACCGGCCTTTACTGAGTATTTATGTACCGACTGAGGCCAATTTGCCGATATTAGAGG
CGGGCAAGCGTCAGCCTGTG

Product: phospholipase D/transphosphatidylase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MFLDFLLGLHFLIWLTISLRVLARHDLSAPARLAWLVVLFILPYVGVVVYWMFGEVHLGINFTHRYDRITQKLAESYPQV
LGDKDTMAQVVEREYQAAGYAASVTGFHTTLGNRAELMADAKATQQRMIADFDAATDHIHVMYYIWLDDDMGTAVGEALM
RAAKRGVRCRAMVDGLGSRKLLRSLLWKRMQDAGVEVSVALPINNLLKVLLFSRIDLRNHRKITVIDGKIGYVGSRNSAD
PEFRIKPKYAPWVDIMLRVQGPLVAQNQMLFANDWLMENPDTDFNSFPYVTEPHPEGIAAQVFADGPTQRQGTTPQFLST
LMSQARHTLIISTPYFVPDYTLINMLCATAYRGVAVSIIFPKNNDSFIVAATSHSYYWQLLEAGVKVYEYKPGLLHAKTL
TVDGKISLIGSTNLDLRSFDLNYENNALFYDEALTAKIVERQYAYIADSDEVMRQEVRDWPIYYRIWINIVSTMGPLL

Sequences:

>Translated_478_residues
MFLDFLLGLHFLIWLTISLRVLARHDLSAPARLAWLVVLFILPYVGVVVYWMFGEVHLGINFTHRYDRITQKLAESYPQV
LGDKDTMAQVVEREYQAAGYAASVTGFHTTLGNRAELMADAKATQQRMIADFDAATDHIHVMYYIWLDDDMGTAVGEALM
RAAKRGVRCRAMVDGLGSRKLLRSLLWKRMQDAGVEVSVALPINNLLKVLLFSRIDLRNHRKITVIDGKIGYVGSRNSAD
PEFRIKPKYAPWVDIMLRVQGPLVAQNQMLFANDWLMENPDTDFNSFPYVTEPHPEGIAAQVFADGPTQRQGTTPQFLST
LMSQARHTLIISTPYFVPDYTLINMLCATAYRGVAVSIIFPKNNDSFIVAATSHSYYWQLLEAGVKVYEYKPGLLHAKTL
TVDGKISLIGSTNLDLRSFDLNYENNALFYDEALTAKIVERQYAYIADSDEVMRQEVRDWPIYYRIWINIVSTMGPLL
>Mature_478_residues
MFLDFLLGLHFLIWLTISLRVLARHDLSAPARLAWLVVLFILPYVGVVVYWMFGEVHLGINFTHRYDRITQKLAESYPQV
LGDKDTMAQVVEREYQAAGYAASVTGFHTTLGNRAELMADAKATQQRMIADFDAATDHIHVMYYIWLDDDMGTAVGEALM
RAAKRGVRCRAMVDGLGSRKLLRSLLWKRMQDAGVEVSVALPINNLLKVLLFSRIDLRNHRKITVIDGKIGYVGSRNSAD
PEFRIKPKYAPWVDIMLRVQGPLVAQNQMLFANDWLMENPDTDFNSFPYVTEPHPEGIAAQVFADGPTQRQGTTPQFLST
LMSQARHTLIISTPYFVPDYTLINMLCATAYRGVAVSIIFPKNNDSFIVAATSHSYYWQLLEAGVKVYEYKPGLLHAKTL
TVDGKISLIGSTNLDLRSFDLNYENNALFYDEALTAKIVERQYAYIADSDEVMRQEVRDWPIYYRIWINIVSTMGPLL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=484, Percent_Identity=34.504132231405, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1787007, Length=377, Percent_Identity=27.3209549071618, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87081826, Length=402, Percent_Identity=27.363184079602, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 54285; Mature: 54285

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLDFLLGLHFLIWLTISLRVLARHDLSAPARLAWLVVLFILPYVGVVVYWMFGEVHLGI
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEE
NFTHRYDRITQKLAESYPQVLGDKDTMAQVVEREYQAAGYAASVTGFHTTLGNRAELMAD
EEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHHHHHH
AKATQQRMIADFDAATDHIHVMYYIWLDDDMGTAVGEALMRAAKRGVRCRAMVDGLGSRK
HHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCEEEHHHCCCCHHH
LLRSLLWKRMQDAGVEVSVALPINNLLKVLLFSRIDLRNHRKITVIDGKIGYVGSRNSAD
HHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCCCC
PEFRIKPKYAPWVDIMLRVQGPLVAQNQMLFANDWLMENPDTDFNSFPYVTEPHPEGIAA
CCEEECCCCCCCEEEEEEECCCEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
QVFADGPTQRQGTTPQFLSTLMSQARHTLIISTPYFVPDYTLINMLCATAYRGVAVSIIF
EEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEE
PKNNDSFIVAATSHSYYWQLLEAGVKVYEYKPGLLHAKTLTVDGKISLIGSTNLDLRSFD
ECCCCCEEEEEECCHHHHHHHHCCCEEEEECCCEEEEEEEEECCEEEEEECCCCEEEEEE
LNYENNALFYDEALTAKIVERQYAYIADSDEVMRQEVRDWPIYYRIWINIVSTMGPLL
CCCCCCEEEEHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCEEEHHHHHHHHHHCCCC
>Mature Secondary Structure
MFLDFLLGLHFLIWLTISLRVLARHDLSAPARLAWLVVLFILPYVGVVVYWMFGEVHLGI
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEE
NFTHRYDRITQKLAESYPQVLGDKDTMAQVVEREYQAAGYAASVTGFHTTLGNRAELMAD
EEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHHHHHH
AKATQQRMIADFDAATDHIHVMYYIWLDDDMGTAVGEALMRAAKRGVRCRAMVDGLGSRK
HHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCEEEHHHCCCCHHH
LLRSLLWKRMQDAGVEVSVALPINNLLKVLLFSRIDLRNHRKITVIDGKIGYVGSRNSAD
HHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCCCCCC
PEFRIKPKYAPWVDIMLRVQGPLVAQNQMLFANDWLMENPDTDFNSFPYVTEPHPEGIAA
CCEEECCCCCCCEEEEEEECCCEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
QVFADGPTQRQGTTPQFLSTLMSQARHTLIISTPYFVPDYTLINMLCATAYRGVAVSIIF
EEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEE
PKNNDSFIVAATSHSYYWQLLEAGVKVYEYKPGLLHAKTLTVDGKISLIGSTNLDLRSFD
ECCCCCEEEEEECCHHHHHHHHCCCEEEEECCCEEEEEEEEECCEEEEEECCCCEEEEEE
LNYENNALFYDEALTAKIVERQYAYIADSDEVMRQEVRDWPIYYRIWINIVSTMGPLL
CCCCCCEEEEHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA