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The map label for this gene is estA [H]

Identifier: 148652774

GI number: 148652774

Start: 1154243

End: 1154908

Strand: Direct

Name: estA [H]

Synonym: PsycPRwf_0967

Alternate gene names: 148652774

Gene position: 1154243-1154908 (Clockwise)

Preceding gene: 148652771

Following gene: 148652775

Centisome position: 38.75

GC content: 49.4

Gene sequence:

>666_bases
ATGACCCACTATTTAGATTGTGTTGTTGTAGAGCATAACCCAGCCAATAAAGACATTGATTGTGCTGTGATTTGGCTACA
TGGCTTAGGGGCCAGTGGCCACGATTTTGAGCCTGTGGTGCCCGAGCTTGGCCTACGCAGCGATCTGGCGGTACGCTTTG
TATTCCCGCATGCGCCCAATATTCCAGTGACCATCAATGGCGGCATGGTGATGCCAGCTTGGTACGATATTTTAGAGATG
AGCTTAGAGCGTAAAGTGGATGTGGCACAAATTGAGAAGTCTGCTGCAGCCATTCATGATTTAATTAATCGTGAGGTTGA
GCGCGGTGTGCCTCATCAAAACATTGTGATTGCCGGCTTCTCTCAAGGCGGGGCGGTGGCCTATCAAGTGGCTTTGACCC
AGCCTGCGCCACTAGCAGGTCTATTGGCACTATCTACGTATTTGGCCATAGACGATGCGGCAAGCTTTATCCAAAACAAA
CAGCTGCCGATTAAGATTGATCATGGGACTCAAGATCCGGTAGTTCCTATTATTTTGGGTCAACGTGCCACAGACAGTCT
AACGGCAGCTGGCTATGACGTAGATTTCTCGACCTACCCCATGGCGCATCAGGTCTGCTTACCACAGCTTCAAGCCATTG
GTCAGTGGCTAAACAACGTACTGTAA

Upstream 100 bases:

>100_bases
AATTACTAAGAAGTTTGTTAAATAGGTAACGTCGCGCAAGTTATTGACGGTGTGACGACACCCAGCGCTGATAACCCATA
AAAATACGATAAGGATAATT

Downstream 100 bases:

>100_bases
CCCCAGCCAATACAGGGATGTTTGATGAGTGTATTAACCCAAGTTAATAAAAGCACGACAGCTCAATCTAAAAAATACGC
AGTGGCTGCCGCTATGCTAC

Product: carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTHYLDCVVVEHNPANKDIDCAVIWLHGLGASGHDFEPVVPELGLRSDLAVRFVFPHAPNIPVTINGGMVMPAWYDILEM
SLERKVDVAQIEKSAAAIHDLINREVERGVPHQNIVIAGFSQGGAVAYQVALTQPAPLAGLLALSTYLAIDDAASFIQNK
QLPIKIDHGTQDPVVPIILGQRATDSLTAAGYDVDFSTYPMAHQVCLPQLQAIGQWLNNVL

Sequences:

>Translated_221_residues
MTHYLDCVVVEHNPANKDIDCAVIWLHGLGASGHDFEPVVPELGLRSDLAVRFVFPHAPNIPVTINGGMVMPAWYDILEM
SLERKVDVAQIEKSAAAIHDLINREVERGVPHQNIVIAGFSQGGAVAYQVALTQPAPLAGLLALSTYLAIDDAASFIQNK
QLPIKIDHGTQDPVVPIILGQRATDSLTAAGYDVDFSTYPMAHQVCLPQLQAIGQWLNNVL
>Mature_220_residues
THYLDCVVVEHNPANKDIDCAVIWLHGLGASGHDFEPVVPELGLRSDLAVRFVFPHAPNIPVTINGGMVMPAWYDILEMS
LERKVDVAQIEKSAAAIHDLINREVERGVPHQNIVIAGFSQGGAVAYQVALTQPAPLAGLLALSTYLAIDDAASFIQNKQ
LPIKIDHGTQDPVVPIILGQRATDSLTAAGYDVDFSTYPMAHQVCLPQLQAIGQWLNNVL

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI9966764, Length=206, Percent_Identity=40.2912621359223, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI5453722, Length=217, Percent_Identity=36.8663594470046, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI20270341, Length=221, Percent_Identity=27.1493212669683, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508057, Length=199, Percent_Identity=33.1658291457286, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323147, Length=212, Percent_Identity=35.8490566037736, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45553055, Length=205, Percent_Identity=32.6829268292683, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45553057, Length=205, Percent_Identity=32.6829268292683, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357257, Length=205, Percent_Identity=32.6829268292683, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161078179, Length=207, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 23945; Mature: 23814

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHYLDCVVVEHNPANKDIDCAVIWLHGLGASGHDFEPVVPELGLRSDLAVRFVFPHAPN
CCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC
IPVTINGGMVMPAWYDILEMSLERKVDVAQIEKSAAAIHDLINREVERGVPHQNIVIAGF
CCEEEECCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SQGGAVAYQVALTQPAPLAGLLALSTYLAIDDAASFIQNKQLPIKIDHGTQDPVVPIILG
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEC
QRATDSLTAAGYDVDFSTYPMAHQVCLPQLQAIGQWLNNVL
CCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THYLDCVVVEHNPANKDIDCAVIWLHGLGASGHDFEPVVPELGLRSDLAVRFVFPHAPN
CCEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCC
IPVTINGGMVMPAWYDILEMSLERKVDVAQIEKSAAAIHDLINREVERGVPHQNIVIAGF
CCEEEECCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SQGGAVAYQVALTQPAPLAGLLALSTYLAIDDAASFIQNKQLPIKIDHGTQDPVVPIILG
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEC
QRATDSLTAAGYDVDFSTYPMAHQVCLPQLQAIGQWLNNVL
CCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA