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The map label for this gene is pyrD

Identifier: 148652741

GI number: 148652741

Start: 1116567

End: 1117601

Strand: Direct

Name: pyrD

Synonym: PsycPRwf_0934

Alternate gene names: 148652741

Gene position: 1116567-1117601 (Clockwise)

Preceding gene: 148652740

Following gene: 148652742

Centisome position: 37.48

GC content: 45.02

Gene sequence:

>1035_bases
ATGTCCTACGCCTTACTACGCCCTTTCTTATTTAATTTAGATCCTGAACATGCTCATGAGCTTACGCTGCAACTGTTAGA
AAAAGCGCACAAAGCTCGGGCGCTTGGTTTTATCTATTCTCAGCAGTCTTTGCCGACTGAATGTATGGGTTTGCAGTTTT
CAAACCCTGTGGGATTGGCAGCCGGCTTAGATAAAAATGGTCAATATATTGATGCGTTGGCTGAGCTTGGTTTTGGCTTT
ATCGAAGTGGGTACTGTGACGCCAAGACCGCAGCAAGGTAATGAAAAACCGCGCTTATTTAGAATCAAAGAGGCCGATGC
GATTATCAACCGTATGGGCTTTAATAATCTAGGGGTGGATCGCTTAATCCAGAACGTTCAGCGTGCAAAATACAAAGGCA
ATATCGGCATAAATATTGGAAAAAATGCAGTGACGCCGGTTGAAAATGCCGCCGATGACTACATATATTGCTTAGACCGC
GTATATCCTCATGCCTCTTATATTACGGTCAATATCTCCTCTCCAAACACCAAAAATCTACGTGACTTGCAAAGTGGTGA
GGCCTTAACTGAGCTGCTAGACAGCATAAAAAACCGTCATAGTCAGCTGGCAACAGAGTATGGGTTTTATGTGCCCATGG
TGCTAAAAGTAGCACCAGACTTAACCCCTGAGCAGGTCGATTATATTGCCAACCAGCTTATTGAATTTGATATTGATGGC
TTGATTGCTACCAATACTACGTTAAGTAGAACAGGGGTAGAGGACTTGCCGTTTGGTGATGAGGCAGGTGGACTCTCAGG
TCGCCCTGTGGGTCATCTAAGTACCCAGATTATCGAACAGTTTTATGAGCGACTAGAGGGTAAGGTGCCTATTATTGGGG
TTGGCGGTATTGATAGTGGAGATAAGGCGGTACGTAAGTTAAACGCTGGCGCTACCATGATACAGCTGTACAGCGGTATG
ATTTATCAAGGGCCAAAACTGGTGCAGCAGTGTGTCGAAGCCATTACCAGTCATCGTGATGCCATGATGCTTTAG

Upstream 100 bases:

>100_bases
GAGTAGAACACAACTTATCTTGAGTAAACCCATAATTGATCGAATGTGCTTGATTGCCATCTTCTAAATTTACTTATTTC
ATAACAGGTTACCTAGCGTT

Downstream 100 bases:

>100_bases
TAAGCCACCAATTGATAAAACAACTAAAGTAGGCGTGGAGAGAGTATGGGGTTTTTAGACATTGTTATTGCCATTATGGT
GCTGGCAGGGTTGTGGCGAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSYALLRPFLFNLDPEHAHELTLQLLEKAHKARALGFIYSQQSLPTECMGLQFSNPVGLAAGLDKNGQYIDALAELGFGF
IEVGTVTPRPQQGNEKPRLFRIKEADAIINRMGFNNLGVDRLIQNVQRAKYKGNIGINIGKNAVTPVENAADDYIYCLDR
VYPHASYITVNISSPNTKNLRDLQSGEALTELLDSIKNRHSQLATEYGFYVPMVLKVAPDLTPEQVDYIANQLIEFDIDG
LIATNTTLSRTGVEDLPFGDEAGGLSGRPVGHLSTQIIEQFYERLEGKVPIIGVGGIDSGDKAVRKLNAGATMIQLYSGM
IYQGPKLVQQCVEAITSHRDAMML

Sequences:

>Translated_344_residues
MSYALLRPFLFNLDPEHAHELTLQLLEKAHKARALGFIYSQQSLPTECMGLQFSNPVGLAAGLDKNGQYIDALAELGFGF
IEVGTVTPRPQQGNEKPRLFRIKEADAIINRMGFNNLGVDRLIQNVQRAKYKGNIGINIGKNAVTPVENAADDYIYCLDR
VYPHASYITVNISSPNTKNLRDLQSGEALTELLDSIKNRHSQLATEYGFYVPMVLKVAPDLTPEQVDYIANQLIEFDIDG
LIATNTTLSRTGVEDLPFGDEAGGLSGRPVGHLSTQIIEQFYERLEGKVPIIGVGGIDSGDKAVRKLNAGATMIQLYSGM
IYQGPKLVQQCVEAITSHRDAMML
>Mature_343_residues
SYALLRPFLFNLDPEHAHELTLQLLEKAHKARALGFIYSQQSLPTECMGLQFSNPVGLAAGLDKNGQYIDALAELGFGFI
EVGTVTPRPQQGNEKPRLFRIKEADAIINRMGFNNLGVDRLIQNVQRAKYKGNIGINIGKNAVTPVENAADDYIYCLDRV
YPHASYITVNISSPNTKNLRDLQSGEALTELLDSIKNRHSQLATEYGFYVPMVLKVAPDLTPEQVDYIANQLIEFDIDGL
IATNTTLSRTGVEDLPFGDEAGGLSGRPVGHLSTQIIEQFYERLEGKVPIIGVGGIDSGDKAVRKLNAGATMIQLYSGMI
YQGPKLVQQCVEAITSHRDAMML

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=329, Percent_Identity=41.6413373860182, Blast_Score=248, Evalue=4e-66,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=52.9761904761905, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17509475, Length=325, Percent_Identity=40, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI281361352, Length=328, Percent_Identity=42.0731707317073, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17137316, Length=328, Percent_Identity=42.0731707317073, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PSYWF (A5WDZ3)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001279834.1
- ProteinModelPortal:   A5WDZ3
- SMR:   A5WDZ3
- STRING:   A5WDZ3
- GeneID:   5204523
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_0934
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- BioCyc:   PSP56811:PSYCPRWF_0934-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37857; Mature: 37726

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYALLRPFLFNLDPEHAHELTLQLLEKAHKARALGFIYSQQSLPTECMGLQFSNPVGLA
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCCCCCEE
AGLDKNGQYIDALAELGFGFIEVGTVTPRPQQGNEKPRLFRIKEADAIINRMGFNNLGVD
ECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHH
RLIQNVQRAKYKGNIGINIGKNAVTPVENAADDYIYCLDRVYPHASYITVNISSPNTKNL
HHHHHHHHHHHCCCEEEEECCCCCCCCHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCH
RDLQSGEALTELLDSIKNRHSQLATEYGFYVPMVLKVAPDLTPEQVDYIANQLIEFDIDG
HHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
LIATNTTLSRTGVEDLPFGDEAGGLSGRPVGHLSTQIIEQFYERLEGKVPIIGVGGIDSG
EEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
DKAVRKLNAGATMIQLYSGMIYQGPKLVQQCVEAITSHRDAMML
HHHHHHHCCCHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SYALLRPFLFNLDPEHAHELTLQLLEKAHKARALGFIYSQQSLPTECMGLQFSNPVGLA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCCCCCEE
AGLDKNGQYIDALAELGFGFIEVGTVTPRPQQGNEKPRLFRIKEADAIINRMGFNNLGVD
ECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHH
RLIQNVQRAKYKGNIGINIGKNAVTPVENAADDYIYCLDRVYPHASYITVNISSPNTKNL
HHHHHHHHHHHCCCEEEEECCCCCCCCHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCH
RDLQSGEALTELLDSIKNRHSQLATEYGFYVPMVLKVAPDLTPEQVDYIANQLIEFDIDG
HHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
LIATNTTLSRTGVEDLPFGDEAGGLSGRPVGHLSTQIIEQFYERLEGKVPIIGVGGIDSG
EEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
DKAVRKLNAGATMIQLYSGMIYQGPKLVQQCVEAITSHRDAMML
HHHHHHHCCCHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA